Allostatic Load in Latino Youth (ALLY) study: The Role of Discrimination and Environmental Racism

拉丁裔青年的均衡负荷 (ALLY) 研究：歧视和环境种族主义的作用

• 批准号: 10677710
• 负责人: Claudia Michele Toledo-Corral
• 金额: $ 18.42万
• 依托单位: CALIFORNIA STATE UNIVERSITY NORTHRIDGE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-05 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677710
• 关键词: Address; Adolescence; Adolescent; Adult; Advocate; Age; Area; Awareness; Behavior; Biological; Biological Markers; Brain; California; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular system; Chronic; Chronic Disease; Clinical; Communities; Complex Mixtures; Data; Data Collection; Development; Diet; Discrimination; Disease; Environmental Exposure; Environmental Impact; Environmental Protection; Environmental Risk Factor; Epidemiology; Ethnic Origin; Evaluation; Exhibits; Exposure to; Failure; Family; Family history of; Functional disorder; Future; Genetic; Health; Health behavior; High Prevalence; Homeostasis; Hydrocortisone; Immune system; Individual; Interdisciplinary Study; Intervention; Knowledge; Latina; Latino; Latinx; Latinx population; Link; Literature; Longitudinal Studies; Longitudinal cohort; Los Angeles; Measures; Mentors; Metabolic; Metabolic syndrome; Nervous System Physiology; Neurosecretory Systems; Non-Insulin-Dependent Diabetes Mellitus; Onset of illness; Pattern; Perception; Phenotype; Physical activity; Physiological; Physiology; Policies; Pollution; Population; Predisposition; Preventive measure; Procedures; Psychosocial Stress; Race; Recording of previous events; Research; Risk; Role; Saliva; Schools; Serum; Sleep; Smoking; Social Environment; Social Justice; Social Policies; Stress; Students; System; Targeted Research; Testing; Time; Training Programs; Universities; Youth; allostatic load; ambient air pollution; biological adaptation to stress; built environment; burden of illness; cardiometabolism; catalyst; cost; design; diabetes risk; disorder risk; environmental justice; environmental stressor; epidemiology study; ethnic difference; ethnic discrimination; ethnic disparity; evidence base; follow-up; high risk; high risk population; hypothalamic-pituitary-adrenal axis; indexing; innovation; lifetime risk; microaggression; middle age; minority children; novel; perceived discrimination; poor health outcome; prevent; programs; psychosocial; psychosocial stressors; public health intervention; racial difference; racial discrimination; racial disparity; racism; social; social culture; social determinants; social implication; sociodemographic factors; stressor; suburb; tool; virtual; young adult

PROJECT SUMMARY It is estimated that by 2050, Latino/a/x will compose over half of the California population, highlighting the critical priority for understanding cardiometabolic health risk in this population. Latinx have a 50% lifetime risk of developing type 2 diabetes and other chronic diseases, a result of a complex mixture of predisposition, health behaviors, and environmental factors. A common physiological mechanism associated to chronic diseases is a failure to maintain homeostasis during times of persistent stress. While ample evidence supports a role of psychosocial stressors on allostatic load, several important challenges have not been yet addressed in Latinx youth, such as the role of racial/ethnic discrimination; therefore there is an urgent need to examine the impact of racial discrimination along with wide-ranging profiles of psychosocial and environmental stressors, in-depth phenotyping of allostatic load, and pertinent biomarkers to identify subsets of high cardiometabolic disease risk individuals. The overarching aim of this proposal is to characterize allostatic load (the result of cumulative stressors on physiology via alterations in brain or nervous system physiology) associated with socio-environmental stressors focused on perceived and imposed (environmental) racial discrimination in Latinx youth. We will leverage a body of literature specific to Los Angeles area Latinx youth to develop an evidence-based allostatic load index and to determine the role of racism, alongside other salient predictors of allostatic load. To test our aims, we will collect two separate waves of data (2-years apart) from the same subjects, Latinx or White, late adolescents/young adults. Data collection will consist of serum and saliva biospecimens for determination of allostatic load indices. A comprehensive panel of 20 allostatic load makers will be utilized representing neuroendocrine, cardiovascular and metabolic components, markers that were specifically selected based on existing literature on allostatic load and knowledge on pathophysiology associated with type 2 diabetes risk in Latinx youth. Additional measures include a cumulative measure of environmental burden (as determined by CalEnviroScreen 4.0), and comprehensive measures of discrimination, psychosocial stress, and health history and behaviors (family history of type 2 diabetes, diet, physical activity, smoking, and sleep). To our knowledge, this will be the first longitudinal study in Latinx vs. White youth specifically designed to characterize allostatic load profiles and to examine the role of racial/ethnic discrimination.

项目摘要 据估计，到2050年，拉丁裔/A/X将占加利福尼亚人口的一半以上，突出显示了 了解该人群中心脏代谢健康风险的关键优先级。 Latinx有50％的终身风险 发展2型糖尿病和其他慢性疾病，这是由于复杂的易感性混合物的结果 健康行为和环境因素。与慢性有关的常见生理机制 在持续压力的时候，疾病无法维持体内平衡。有足够的证据支持 社会心理压力源在同性恋负荷上的作用，尚未解决一些重要的挑战 在拉丁裔青年中，例如种族/种族歧视的作用；因此，迫切需要检查 种族歧视以及社会心理和环境的广泛概况的影响 压力源，同种异体负荷的深入表型以及相关的生物标志物，以识别高的子集 心脏代谢疾病风险个体。该提案的总体目的是表征同性恋负载 （通过改变脑或神经系统生理学的改变生理压力的结果） 与社会环境压力源相关的是感知和强加的（环境）种族 拉丁裔青年的歧视。我们将利用特定于洛杉矶地区拉丁裔青年的文学体系 制定循证同性载荷指数并确定种族主义的作用，并与其他显着性一起 同性载荷的预测指标。为了测试我们的目标，我们将收集两个单独的数据浪潮（相距2年） 同一受试者，拉丁裔或白色，晚期青少年/年轻人。数据收集将包括血清和 用于确定同层负荷指数的唾液生物测量。全面的20个同级负载的综合面板 将使用代表神经内分泌，心血管和代谢成分的标记的制造商 根据现有的有关同种异体负荷和病理生理知识的文献专门选择 与2型糖尿病风险相关的拉丁裔青年风险。其他措施包括累积措施 环境负担（由Calenviroscreen 4.0确定），并采取了全面的措施 歧视，社会心理压力以及健康史和行为（2型糖尿病的家族史，饮食， 体育锻炼，吸烟和睡眠）。据我们所知，这将是Latinx vs中的首次纵向研究。 白人青年专门设计用于表征同性恋负荷概况并研究种族/种族的作用 歧视。