National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): Administrative Resource

国家青少年酒精与神经发育联盟 (NCANDA)：行政资源

基本信息

批准号：
10677643
负责人：
SANDRA A BROWN
金额：
$ 54.64万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-05 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10677643
关键词：
21 year old Acceleration Acute Address Adolescence Adolescent Adolescent and Young Adult Adult Affect Age Alcohol abuse Alcohol consumption Alcohols Authorship Behavior Behavioral Biological Brain COVID-19 pandemic effects Career Mobility Clinical Cognition Cognitive Communication Communities Complement Computers Conflict (Psychology)Data Data Analyses Data Collection Development Disputes Economics Elements Emotional Ensure Evaluation Female Functional Magnetic Resonance Imaging Gender Goals Growth Health Sciences Heart Rate Heavy Drinking Home Independent Living Individual International Interview Leadership Learning Life Link Magnetic Resonance Imaging Measures Memory Mission Modeling Monitor National Institute on Alcohol Abuse and Alcoholism Oregon Outcome Patient Recruitments Pattern Performance Personal Satisfaction Persons Physical activity Policies Positioning Attribute Procedures Process Protocols documentation Psychopathology Recovery Reporting Research Research Project Grants Resolution Resources Rest Risk Risk Factors Sampling Schools Science Sex Differences Site Site Visit Sleep Sleep disturbances Standardization Stress Structure Symptoms System Technology Testing Training Trust Universities Vision Work Youth addiction alcohol cue alcohol effect alcohol use disorder alcohol use initiation binge drinking career career development cognitive performance cohort cue reactivity data standards design drinking emerging adult emerging adulthood follow-up gray matter hazardous drinking heart function improved longitudinal design male medical specialties meetings mobile application modifiable risk multimodal neuroimaging neural neurodevelopment neuroimaging novel post-pandemic pre-pandemic programs prospective response retention rate social success underage drinking young adult young man young woman

项目摘要

PROJECT SUMMARY Excessive alcohol drinking Initiated during adolescence is known to disturb typical neurodevelopmental patterns, increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood. In response to RFA-AA-21-008, the Administrative Resource (AR) proposes to coordinate activities of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a diverse community sample of male and female participants recruited in three age bands (12- 14, 15-17, 18-21 years old) as mostly no-to-low drinkers, tracked over the last 8 years across 5 sites (N=831; 93% retention rate). This consortium reflects seven applications: NCANDA - Administrative Resource (UCSD) and NCANDA - Data Analysis Resource (SRI), and five cross-national Research Project Sites, located at Duke University (Duke), Oregon Health Science University (OHSU), University of Pittsburgh (Pitt), SRI International (SRI), and UC San Diego (UCSD). Monitoring has involved annually multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep and physical activity tracking. Our accelerated longitudinal design uniquely positions NCANDA-A (ages 18-34) to quantify transient or enduring alcohol-related disturbances in adolescent and early adult neural system growth trajectories and functional concomitants. NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, we investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2 identifies the extent to which alcohol’s effects on brain structure and function resolve or persist during desistance of binge drinking. Aim 3 identifies adolescent biological, environmental, and behavioral factors that forecast excessive drinking during early adulthood. Aim 4 quantifies COVID-19 pandemic impact on alcohol use, stress, and wellbeing. Aim 5 (SRI and Pittsburgh sites) identifies interactions among alcohol use, sleep, and cardiac function. Aim 6 (UCSD, Duke and OHSU sites) determines the extent to which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal of structural and functional brain effects of binge alcohol use. For each aim, sex differences will be tested. With longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel information on the enduring and transient effects of adolescent drinking on adult functioning by discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.

项目概要众所周知，青春期期间开始的过量饮酒会扰乱典型的神经发育模式，增加酒精产生使用障碍（AUD）的风险，并加速成年期的退化过程。为了回应 RFA-AA-21-008，行政资源 (AR) 建议协调国家酒精与青春期-成人期神经发育联盟 (NCANDA-A) 关注在接下来的 5 年里，我们将在三个年龄段（12- 过去 8 年在 5 个地点进行了追踪（N=831；14、15-17、18-21 岁），大多数为无饮酒至低度饮酒者。 93% 的保留率）。该联盟反映了七个应用程序：NCANDA - 行政资源 (UCSD)。和 NCANDA - 数据分析资源 (SRI)，以及位于杜克大学的五个跨国研究项目站点大学 (杜克大学)、俄勒冈健康科学大学 (OHSU)、匹兹堡大学 (Pitt)、SRI International (SRI) 和加州大学圣地亚哥分校 (UCSD) 每年进行多模式神经影像检查（MRI、DTI、静息）。状态功能磁共振成像（fMRI）、任务功能磁共振成像（task fMRI）、认知、临床、行为和生物数据，亲自或远程收集这些措施现在将得到新的先进神经影像学的补充。我们的加速纵向设计使 NCANDA-A 具有独特的地位。（18-34 岁）量化青少年和早期成人神经系统中短暂或持久的酒精相关紊乱系统增长轨迹和功能伴随物。 NCANDA-A 提出了四个联盟范围内的具体目标和两个专业项目目标。在目标 1 中，我们进行了调查。青春期和成年初期过量饮酒对以后的影响认知表现、大脑结构和功能以及精神病理学的发展轨迹。确定酒精对大脑结构和功能的影响在戒烟期间消退或持续的程度目标 3 青少年的生物、环境和行为因素确定了这一预测。目标 4 量化了 COVID-19 大流行对饮酒、压力、目标 5（SRI 和匹兹堡站点）确定饮酒、睡眠和心脏之间的相互作用。目标 6（UCSD、杜克大学和 OHSU 中心）确定短期（即 4 周）饮酒的程度。停止使用会导致认知、情感、睡眠和静息心率的急剧改善以及逆转酗酒对大脑结构和功能的影响对于每个目标，都将测试性别差异。通过在更新期间收集到成年早期的纵向数据，NCANDA-A 将提供新颖的通过发现青少年饮酒对成人功能的持久和短暂影响的信息连接这些动态过程并识别可改变的风险因素的要素和机制。