Data-driven, peer-led messaging using social media influencers to increase PrEP awareness and uptake among transgender women

利用社交媒体影响者进行数据驱动、同行主导的信息传递，以提高跨性别女性的 PrEP 意识和采用率

• 批准号: 10674866
• 负责人: Sarah B Bass
• 金额: $ 28.58万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674866
• 关键词: 3-Dimensional; AIDS prevention; Address; Adherence; Affect; Area; Attitude; Awareness; Bass; Behavioral; Caring; Clinical; Collection; Communication; Communities; Consult; Counseling; Data; Decision Making; Dimensions; Discrimination; Funding; Future; HIV; HIV Infections; Hair; Health; Image; Instagram; Intervention; Knowledge; Location; Los Angeles; Maps; Marketing; Measures; Medical; Methods; Modeling; Monitor; National Institute of Mental Health; New York; Outcome; Participant; Perception; Persons; Philadelphia; Prophylactic treatment; Reporting; Research; Resources; Sampling; San Francisco; Sister; Social Development; Standardization; Surveys; Techniques; Testing; Training; Trust; United States; Work; acceptability and feasibility; artist; clinical research site; cohort; design; experience; gender affirmation; health care settings; health communication; high risk; hormone therapy; implementation evaluation; implementation framework; implementation intervention; implementation science; improved; innovation; insight; mathematical model; member; novel; peer; pilot test; pre-exposure prophylaxis; recruit; social; social engagement; social interventions; social media; social stigma; tool; transgender; transgender women; uptake; vector

Project Summary Transgender women (TW) are at significantly higher risk of getting HIV, yet research indicates they are less likely to use pre exposure prophylaxis (PrEP) and continue to have misconceptions about its utility. Trans- inclusive communication, delivered by trusted peers, is a potentially useful strategy to address this gap, but reaching a large number of TW can be difficult. The SIS (Sisters Influencing Sisters) study will use preliminary findings from a NIMH funded R21 that utilized commercial marketing techniques called perceptual mapping and vector message modeling to develop and concept test TW specific PrEP messages. Using the Gender Affirmation Framework and the EPIS Implementation Framework as guides, we propose to embed these tested PrEP messages and materials in the SIS intervention and pilot it using TW social influencers (SIs) via Instagram. Specific aims of the research are: Aim 1: Design a community-led, social-media based PrEP messaging training for TW SIs. We will recruit a Community Advisory Board (CAB) who will consult on all aspects of the study, including the development of an SI training and recruitment of SIs, tools/measures, dissemination of findings, and input on a future trial. Aim 2: Refine PrEP messaging materials, design the SIS intervention modules, and identify and train TW SIs. We will finalize PrEP messaging materials, engaging trans artists to refine images and convert to social media formats. With the help of our CAB, we will identify and engage SIs on social media from two intervention locations (San Francisco Bay, Philadelphia) and two comparison locations (New York and Los Angeles). Intervention SIs will be trained on the SIS intervention content as well as delivery of clinical referrals and resources to their communities. Aim 3: Aim 3: Pilot test the SIS intervention to collect feasibility, acceptability, and preliminary efficacy data to inform a full trial. We will implement standardized core components of the Instagram-based intervention, evaluate dissemination and reach of the PrEP messages, and monitor and evaluate engagement with the materials. To assess promise of efficacy, we will identify a cohort of 120 followers (80 intervention, 40 comparison) to complete baseline, mid and end of intervention surveys to track changes and compare levels of PrEP knowledge and PrEP perceptions. We will also pilot remote collection of hair samples to monitor PrEP uptake and use in a subsample of participants (n=30; 5 each SI) and do in-depth intervention implementation evaluation. We expect that findings will significantly contribute to our understanding of how to communicate with a diverse group of TW, how to leverage social media as a powerful communication channel, and how to disseminate information to increase PrEP awareness and uptake by addressing the unique HIV prevention needs and concerns of TW.

项目概要 跨性别女性 (TW) 感染艾滋病毒的风险明显较高，但研究表明她们的感染风险较低 可能使用暴露前预防 (PrEP) 并对其效用仍然存在误解。反式 由值得信赖的同行提供的包容性沟通是解决这一差距的潜在有用策略，但是 达到大量 TW 可能很困难。 SIS（姐妹影响姐妹）研究将使用 NIMH 资助的 R21 的初步调查结果利用了称为感知的商业营销技术 映射和矢量消息建模，用于开发和概念测试 TW 特定的 PrEP 消息。使用 性别肯定框架和 EPIS 实施框架作为指导，我们建议嵌入 这些在 SIS 干预中经过测试的 PrEP 信息和材料，并使用台湾社会影响者 (SI) 进行试点 通过Instagram。该研究的具体目标是： 目标 1：设计一个社区主导、基于社交媒体的 PrEP 针对台湾 SI 的消息传递培训。我们将招募一个社区咨询委员会（CAB），他将就所有问题进行咨询 研究的各个方面，包括 SI 培训的开发和 SI 的招募、工具/措施、 传播研究结果以及对未来试验的投入。目标 2：完善 PrEP 信息材料，设计 SIS 干预模块，并识别和培训 TW SI。我们将最终确定 PrEP 信息材料，吸引 跨性别艺术家可以优化图像并转换为社交媒体格式。在我们的 CAB 的帮助下，我们将识别并 在两个干预地点（旧金山湾、费城）和两个干预地点通过社交媒体吸引 SI 比较地点（纽约和洛杉矶）。干预 SI 将接受有关 SIS 干预的培训 内容以及向社区提供临床转诊和资源。目标 3： 目标 3：试点测试 SIS 干预收集可行性、可接受性和初步疗效数据，为全面试验提供信息。我们 将实施基于 Instagram 的干预措施的标准化核心组件，评估传播和 PrEP 信息的覆盖范围，并监测和评估材料的参与度。评估承诺 功效，我们将确定一个由 120 名关注者组成的队列（80 名干预，40 名比较）来完成基线、中期和 干预调查结束，以跟踪变化并比较 PrEP 知识和 PrEP 认知水平。我们 还将试点远程收集头发样本，以监测参与者子样本的 PrEP 吸收和使用情况 （n=30；每个SI 5个）并进行深入的干预实施评估。我们预计调查结果将 极大地有助于我们理解如何与不同的台湾群体沟通，如何利用 社交媒体作为强大的沟通渠道，以及如何传播信息以增加 PrEP 通过解决台湾独特的艾滋病毒预防需求和关注点来提高认识和吸收。