Midcareer Investigator Award in Patient-Oriented NeuroAIDS Research

以患者为导向的神经艾滋病研究中职业生涯调查员奖

• 批准号: 8774931
• 负责人: Scott L Letendre
• 金额: $ 18.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-07 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8774931
• 关键词: Address; Affect; Anti-Retroviral Agents; Appointment; Area; Award; Biological Assay; Biological Markers; Brain; Chronic Disease; Clinical Research; Clinical Research Curriculum Award; Clinical Trials; Collaborations; Continuing Education; Cytomegalovirus; Data; Development; Diagnosis; Diagnostic; Disease; Doctor of Medicine; Drug Interactions; Drug Kinetics; Education; Education Projects; Educational process of instructing; Equipment; Event; Faculty; Fellowship; Fibroblast Growth Factor; Funding; Goals; Grant; HIV; HIV-associated neurocognitive disorder; Hepatitis C virus; Individual; Infection; Influentials; Institutional National Research Service Award; International; Junior Physician; K-Series Research Career Programs; Laboratories; Lead; Leadership; Life; Light; Measurement; Measures; Medical Students; Medicine; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; National Institute of Mental Health; Nebraska; Nervous system structure; Neurocognitive; Neurologic; Outcome; Performance; Pharmaceutical Preparations; Pharmacology; Plasma; Plasmodium; Population; Postdoctoral Fellow; Prognostic Marker; Proteins; Regimen; Research; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Scientist; Secure; Time; Toxoplasma; Training; Translational Research; Wages; Work; addiction; antimicrobial; antiretroviral therapy; career; co-infection; cost; design; drug distribution; graduate student; instrument; interdisciplinary approach; interest; longitudinal analysis; nervous system disorder; neuroAIDS; neurocognitive disorder; neurofilament; outcome forecast; pathogen; patient oriented; patient oriented research; professor; public health relevance; screening; skills; success; young adult

DESCRIPTION (provided by applicant): Scott Letendre, M.D. is an Associate Professor of Medicine at UCSD and former K23 Career Development Award recipient. In the past decade, Dr. Letendre has led or collaborated on many publicly and privately funded translational research projects. His influential work has focused on the risk factors and treatment of HIV-associated neurocognitive disorder (HAND) in the US and international settings. During this period, he has also mentored more than 30 trainees in patient-oriented research, including graduate and medical students, post-doctoral researchers, and junior faculty. In the proposed K24 mid-career investigator award, Dr. Letendre will expand his mentoring of junior investigators and will focus his mentoring and his own research on three main objectives. Antiretroviral treatment of the nervous system: Dr. Letendre will mentor trainees on design and performance of HAND clinical trials and CSF pharmacology projects, particularly focusing on longitudinal projects that measure all drugs in an antiretroviral regimen to better understand how drug interactions and time influence virologic and neurocognitive outcomes. Biomarker correlates of disease and treatment: Dr. Letendre will mentor trainees on measurement and analysis of biomarker data with the goal of developing a clinically useful panel for screening, diagnosis, and prognosis of HAND. This work will be supported by new equipment purchased with funds from a recent S10 Shared Instrument Grant. Coinfections in HIV-infected individuals: Dr. Letendre will work with trainees on projects that evaluate the impact on the nervous system of latent or minimally symptomatic infections with pathogens such as Plasmodium, Cytomegalovirus, Toxoplasma, and hepatitis C virus. This work will particularly focus on Dr. Letendre's existing work in international settings. Dr. Letendre will mentor trainees using a multidisciplinary approach that includes regular direct engagement, participation in R25, T32, and K30 programs at UCSD, active participation in existing research projects, support for new research projects, and networking with other investigators. Dr. Letendre will also obtain training in mentoring and analysis of longitudinal data. In summary, this K24 award will secure protected time for Dr. Letendre to mentor trainees in neuroAIDS methods, including the responsible conduct of patient- oriented research. Dr. Letendre will coordinate his efforts with other UCSD resources, including the R25- funded "International Research Fellowship in NeuroAIDS", the T32-funded "Training in Research on Addictions in Interdisciplinary NeuroAIDS", and the CTSA-funded "Clinical and Translational Research Institute".

描述（由申请人提供）：Scott Letendre，医学博士，加州大学圣地亚哥分校医学副教授，前 K23 职业发展奖获得者。在过去的十年中，Letendre 博士领导或合作了许多公共和私人资助的转化研究项目。他颇具影响力的工作重点是美国和国际环境下艾滋病毒相关神经认知障碍 (HAND) 的危险因素和治疗。在此期间，他还指导了 30 多名以患者为导向的研究学员，包括研究生和医学生、博士后研究人员和初级教师。在拟议的 K24 职业生涯中期研究员奖中，Letendre 博士将扩大他对初级研究员的指导，并将他的指导和自己的研究集中在三个主要目标上。神经系统的抗逆转录病毒治疗：Letendre 博士将指导学员设计和执行 HAND 临床试验和 CSF 药理学项目，特别关注测量抗逆转录病毒治疗方案中所有药物的纵向项目，以更好地了解药物相互作用和时间如何影响病毒学和治疗神经认知结果。生物标志物与疾病和治疗的相关性：Letendre 博士将指导学员测量和分析生物标志物数据，目标是开发临床上有用的面板，用于 HAND 的筛查、诊断和预后。这项工作将得到由最近 S10 共享仪器拨款资助购买的新设备的支持。 HIV感染者的合并感染：Letendre博士将与学员合作开展项目，评估疟原虫、巨细胞病毒、弓形虫和丙型肝炎病毒等病原体的潜伏或轻微症状感染对神经系统的影响。这项工作将特别关注 Letendre 博士在国际环境中的现有工作。 Letendre 博士将采用多学科方法指导学员，包括定期直接参与、参与 UCSD 的 R25、T32 和 K30 项目、积极参与现有研究项目、支持新研究项目以及与其他研究人员建立联系。 Letendre 博士还将获得纵向数据指导和分析方面的培训。总之，该 K24 奖项将为 Letendre 博士提供受保护的时间来指导神经艾滋病方法的学员，包括负责任地进行以患者为导向的研究。 Letendre 博士将与 UCSD 的其他资源协调工作，包括 R25 资助的“神经艾滋病国际研究奖学金”、T32 资助的“跨学科神经艾滋病成瘾研究培训”以及 CTSA 资助的“临床和转化研究”研究所”。