Administrative Core

行政核心

• 批准号: 10673657
• 负责人: Vincent Mor
• 金额: $ 468.65万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673657
• 关键词: Aging; Agreement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Caregivers; Caring; Clinical Trials; Clinical Trials Design; Collaborations; Committee Members; Communication; Complex; Data; Databases; Dedications; Dementia; Development; Doctor of Philosophy; Elements; Ensure; Funding; Grant; Healthcare Systems; Home; Human Resources; Infrastructure; Institution; Institutional Review Boards; K-Series Research Career Programs; Knowledge; Leadership; Life; Life Cycle Stages; Link; Logistics; Maintenance; National Institute on Aging; Outcome; Persons; Pilot Projects; Pragmatic clinical trial; Preparation; Principal Investigator; Productivity; Public Health Schools; Recording of previous events; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Role; Scientist; Services; Site; Structure; Sum; United States National Institutes of Health; Universities; care outcomes; care systems; career development; collaboratory; data enclave; data sharing; data standards; design; diversity and inclusion; experience; improved; innovation; service providers; success; systems research; training opportunity; web site; working group

PROJECT SUMMARY The National Institute on Aging (NIA) Alzheimer's disease (AD) and AD-related dementia (AD/ADRD) Collaboratory will serve as a national resource to promote the development and conduct of embedded pragmatic clinical trials (ePCTs) to improve care and outcomes for persons with dementia (PWD) and their caregivers, in partnership with the various healthcare systems (HCS) that deliver their care. To achieve this objective, the Collaboratory must be more than just a sum of its parts. An initiative of this scope requires not only that each component has the requisite infrastructure and resources, but also that activities are synergistically integrated across components. To do so will require an exceptional Administration and Management Core. The Core’s Specific Aims are to: Aim 1. Administer, manage, and integrate all the components of the AD/ADRD Collaboratory; Aim 2. Coordinate support and guidance for pilot project and NIA-funded investigators conducting ePCTs in PWD from the Working Group Cores and Administration Teams; and Aim 3. Coordinate the development and dissemination of all products, guidance materials, and training opportunities for key aspects of conducting ePCTs in PWD and their caregivers. Several factors will enable the Core to meet its formidable task. First, it will benefit from the experienced and cohesive leadership of the Multiple Principal Investigators (MPIs), Drs. Vincent Mor (Brown University School of Public Health) and Susan Mitchell (Hebrew Senior Life Institute for Aging Research (HSL IFAR)). Second administrative responsibilities will be supported by the rich research infrastructures of their institutions which have a long history of collaboration. Two highly-accomplished Executive Directors will lead the teams at each site; Rosa Baier MPH (Brown) and Ellen McCarthy PhD (HSL IFAR). Third, administrative functions will be organized across eight Teams (four per site) as follows: 1. Grants Administration (Brown); 2. Organization and Logistics (Brown); 3. Institutional Review Board (IRB)/Regulatory (Brown), 4. Data Sharing and Standards (Brown), 5. Investigator Navigation (HSL IFAR), 6. Communication and Knowledge Dissemination (HSL IFAR), 7. Stakeholder Engagement (HSL IFAR), and 8. Diversity and Inclusion (HSL IFAR). Finally, specialized service providers will be engaged to manage large, critical tasks that can be done more efficiently with their expertise (e.g. website creation and maintenance, single Institutional Review Board (sIRB)). Particularly innovative functions of the Core include: organizing proactive project support, coordinating the mandatory sIRB, hosting a common REDCap database, and a dedicated Team to ensure issues related to diversity and inclusion are met in all aspects of ePCT design. IMPACT: The proposed AD/ADRD Collaboratory has all the necessary ingredients for success: strong leadership, ample resources, experts leading the Working Group Cores and Teams, and a highly-impactful agenda. However, all these elements must be supported and integrated for the Collaboratory to transform the delivery, quality, and outcomes of care for PWD and their caregivers. The Administration and Management Core serves a critical role in achieving that objective.

项目摘要 美国国家衰老研究所（NIA）阿尔茨海默氏病（AD）和与广告有关的痴呆症（AD/ADRD） 协作将作为国家资源，以促进嵌入式务实的发展和行为 临床试验（EPCT），以改善痴呆症患者（PWD）及其护理人员的护理和结果 与提供护理的各种医疗系统（HCS）的合作关系。为了实现这一目标， 协作不仅仅是其部分的总和。此范围的主动性不仅需要每个范围 组件具有必要的基础架构和资源，但活动是协同整合的 跨组件。这样做将需要杰出的管理和管理核心。核心的 具体目的是：AIM 1。管理，管理和集成广告/ADRD的所有组件 协作；目标2。协调试点项目的支持和指导和NIA资助的调查人员进行 工作组核心和行政团队的PWD中的EPCT；和目标3。协调 为关键方面的所有产品，指导材料和培训机会开发和传播 在PWD及其护理人员中进行EPCT。几个因素将使核心能够满足其强大的任务。 首先，它将受益于多个主要研究人员（MPI）的经验丰富和凝聚力的领导 博士。文森特·莫（Vincent Mor）（布朗大学公共卫生学院）和苏珊·米切尔（Susan Mitchell）（希伯来语高级生命研究所 老化研究（HSL IFAR））。第二个行政责任将得到丰富的研究 其机构的基础设施具有悠久的合作历史。两位高度合并的高管 董事将领导每个站点的团队； Rosa Baier MPH（Brown）和Ellen McCarthy博士（HSL IFAR）。第三， 行政职能将在八个团队（每个站点四个）之间组织：1。赠款管理 （棕色的）; 2。组织和后勤（棕色）； 3。机构审查委员会（IRB）/监管（Brown），4。数据 共享和标准（Brown），5。研究者导航（HSL IFAR），6。沟通和知识 传播（HSL IFAR），7。利益相关者参与（HSL IFAR）和8。多样性和包容性（HSL IFAR）。 最后，专门的服务提供商将参与管理大型至关重要的任务，可以做更多的任务 有效地利用其专业知识（例如网站创建和维护，单机构审查委员会（SIRB））。 核心的特别创新功能包括：组织主动的项目支持，协调 强制性SIRB，托管一个常见的REDCAP数据库和一个专门的团队，以确保与 在EPCT设计的各个方面都满足了多样性和包容性。影响：拟议的广告/ADRD合作 拥有成功的所有必要范围：强大的领导力，充足的资源，领导工作的专家 小组核心和团队，以及高度影响的Agernda。但是，所有这些要素必须得到支持，并且 为了改变PWD的交付，质量和护理成果而集成为PWD及其 照顾者。政府和管理核心在实现这一目标方面发挥着关键作用。