Clinical Translational Research Center for Neurodevelopmental Disorders

神经发育障碍临床转化研究中心

• 批准号: 10673835
• 负责人: GABRIEL S DICHTER
• 金额: $ 124.4万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-28 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673835
• 关键词: 2 year old; Address; Affect; Angelman Syndrome; Applied Research; Basic Science; Behavior; Brain; Caliber; Center for Translational Science Activities; Cerebrospinal Fluid; Child; Circulation; Clinical; Clinical Research; Clinical Sciences; Clinical Services; Collaborations; Communities; Complex; Data; Data Science Core; Dedications; Development; Developmental Disabilities; Diagnosis; Discipline; Early Diagnosis; Early Intervention; Environment; Etiology; Family; Fostering; Fragile X Syndrome; Functional disorder; Funding; Genetic; Genomics; Goals; Grant; Impairment; Individual; Infant; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; Intervention; Laboratories; Link; Meningeal lymphatic system; Microscopy; Mus; Nature; Neurodevelopmental Disorder; Neurosciences; North Carolina; Participant; Pathogenesis; Pathogenicity; Personal Satisfaction; Phenotype; Play; Prevention; Prevention strategy; Proteins; Rattus; Registries; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Role; Science; Syndrome; Training; Translational Research; United States National Institutes of Health; Universities; animal imaging; autism spectrum disorder; behavior measurement; behavioral phenotyping; brain behavior; clinical training; clinical translation; collaborative environment; cost effective; educational atmosphere; imaging facilities; improved; insight; mouse model; multidisciplinary; neuroinflammation; novel; pre-clinical; predictive marker; programs; response; synergism; targeted treatment; therapy development

Project Summary The University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is an interdisciplinary program with the overarching goal of supporting and promoting research relevant to understanding the pathogenesis and treatment of neurodevelopmental disorders. The UNC IDDRC is a critical component of the new Carolina Institute for Developmental Disabilities (CIDD), which is the focal point for clinical services, research, and training relevant to intellectual and developmental disabilities (IDDs) on the UNC campus. The UNC IDDRC currently supports 46 investigators from 13 University departments, and includes 89 externally-funded research projects. The broad-based research program of this IDDRC is integrated around 3 themes: (1) Brain and Behavior Development; (2) Autism and Related Neurodevelopmental Disorders; and, (3) Early Detection/Intervention. The UNC IDDRC is a highly collaborative program highlighted by the presence of several NIH-funded, interdisciplinary research centers/programs. This application seeks support for: (1) an Administrative Core; (2) three research cores – the Clinical Translational Core, which includes the Research Participant Registry and Brain-Behavior Measurement Laboratory; the PreClinical Core, which includes the Mouse Behavioral Phenotyping Laboratory, Neuroscience Microscopy Facility, and Small Animal Imaging Facility; the Data Science Core Core; and (3) a pre-clinical/clinical research project entitled “Cerebrospinal fluid abnormalities in neurodevelopmental disorders” that proposes to examine role of CSF pathophysiology in the pathogenesis of selected neurodevelopmental disorders. The three proposed research cores provide cutting-edge, high-quality and cost effective support for this integrated, multidisciplinary, translational program of IDD-relevant research. Overall, this Center has had a major impact on developmental disabilities research and scientific training at the University of North Carolina, and renewal would allow us to continue our support of the truly exceptional program of IDD research conducted at UNC.

项目概要 北卡罗来纳大学智力与发育障碍研究中心 (IDDRC) 是一个 跨学科计划，其总体目标是支持和促进相关研究 了解神经发育障碍的发病机制和治疗至关重要。 是新成立的卡罗莱纳发育障碍研究所 (CIDD) 的组成部分，该研究所是 与智力和发育障碍 (IDD) 相关的临床服务、研究和培训 北卡罗来纳大学校园。北卡罗来纳大学 IDDRC 目前支持来自 13 个大学系的 46 名研究人员，以及 包括 89 个外部资助的研究项目。 围绕 3 个主题进行整合：(1) 大脑和行为发展；(2) 自闭症及相关疾病 神经发育障碍；(3) 早期检测/干预。 合作项目以 NIH 资助的多项跨学科研究为重点 该申请寻求支持：(1) 一个行政核心；(2) 三个研究核心 – 临床转化核心，包括研究参与者登记和大脑行为 测量实验室；临床前核心，包括小鼠行为表型实验室， 神经科学显微镜设施和小动物成像设施；数据科学核心；以及 (3) 题为“神经发育中的脑脊液异常”的临床前/临床研究项目 疾病”，建议检查脑脊液病理生理学在选定的发病机制中的作用 拟议的三个研究核心提供尖端、高质量和成本。 为 IDD 相关研究的综合、多学科、转化项目提供有效支持。 该中心对发育障碍研究和科学培训产生了重大影响 北卡罗来纳大学，续约将使我们能够继续支持真正杰出的 北卡罗来纳大学开展的 IDD 研究计划。

项目成果

Structural and functional connectome relationships in early childhood.

• DOI: 10.1016/j.dcn.2023.101314
• 发表时间: 2023-12
• 期刊: DEVELOPMENTAL COGNITIVE NEUROSCIENCE
• 影响因子: 4.7
• 作者: Hong, Yoonmi;Cornea, Emil;Girault, Jessica B.;Bagonis, Maria;Foster, Mark;Kim, Sun Hyung;Prieto, Juan Carlos;Chen, Haitao;Gao, Wei;Styner, Martin A.;Gilmore, John H.
• 通讯作者: Gilmore, John H.

Mental health Project ECHO Autism: Increasing access to community mental health services for autistic individuals.

• DOI: 10.1177/13623613211028000
• 发表时间: 2022-03
• 期刊: Autism : the international journal of research and practice
• 作者: Dreiling NG;Cook ML;Lamarche E;Klinger LG
• 通讯作者: Klinger LG

Longitudinal Prediction of Infant MR Images With Multi-Contrast Perceptual Adversarial Learning.

• DOI: 10.3389/fnins.2021.653213
• 发表时间: 2021
• 期刊: Frontiers in neuroscience
• 影响因子: 4.3
• 作者: Peng L;Lin L;Lin Y;Chen YW;Mo Z;Vlasova RM;Kim SH;Evans AC;Dager SR;Estes AM;McKinstry RC;Botteron KN;Gerig G;Schultz RT;Hazlett HC;Piven J;Burrows CA;Grzadzinski RL;Girault JB;Shen MD;Styner MA
• 通讯作者: Styner MA

Mapping the evolution of regional brain network efficiency and its association with cognitive abilities during the first twenty-eight months of life.

• DOI: 10.1016/j.dcn.2023.101284
• 发表时间: 2023-10
• 期刊: DEVELOPMENTAL COGNITIVE NEUROSCIENCE
• 影响因子: 4.7
• 作者: Jiang, Weixiong;Zhou, Zhen;Li, Guoshi;Yin, Weiyan;Wu, Zhengwang;Wang, Li;Ghanbari, Maryam;Li, Gang;Yap, Pew-Thian;Howell, Brittany R.;Styner, Martin A.;Yacoub, Essa;Hazlett, Heather;Gilmore, John H.;Smith, J. Keith;Ugurbil, Kamil;Elison, Jed T.;Zhang, Han;Shen, Dinggang;Lin, Weili
• 通讯作者: Lin, Weili

Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration.

• DOI: 10.1038/s41419-021-04422-z
• 发表时间: 2021-12-06
• 期刊: Cell death & disease
• 影响因子: 9
• 作者: Cleveland AH;Romero-Morales A;Azcona LA;Herrero M;Nikolova VD;Moy S;Elroy-Stein O;Gama V;Gershon TR
• 通讯作者: Gershon TR