Psychosocial and neurobiological stress and opioid use trajectories following pregnancy

怀孕后的心理社会和神经生物学压力以及阿片类药物的使用轨迹

• 批准号: 10673115
• 负责人: Helena JV Rutherford
• 金额: $ 55.65万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673115
• 关键词: Behavior; Birth; Brain; Brain region; Characteristics; Child; Child Rearing; Cues; Data; Development; Distress; Electronic Health Record; Evidence based intervention; Exhibits; Exposure to; Financial Support; Generations; Gestational Age; Health; Individual; Infant; Intervention; Knowledge; Low Birth Weight Infant; Maintenance; Measures; Medial; Modeling; Mothers; Motor; Negative Valence; Neurobiology; Neuronal Plasticity; Opiate Addiction; Opioid; Parents; Participant; Pattern; Personal Satisfaction; Pharmaceutical Preparations; Phenotype; Population; Postpartum Period; Pregnancy; Pregnant Women; Prevention; Prevention approach; Process; Psychosocial Assessment and Care; Psychosocial Stress; Public Health; Recommendation; Relapse; Reporting; Research; Risk; Role; Scanning; Sensory; Shapes; Stimulus; Stress; Substance Addiction; Substance abuse problem; Symptoms; System; Third Pregnancy Trimester; Time; Treatment outcome; Withdrawal Symptom; Woman; Work; addiction; biobehavior; biological adaptation to stress; cortico-limbic circuits; craving; hedonic; improved; longitudinal design; maternal opioid use; maternal stress; medication-assisted treatment; neural; neuroimaging; neuromechanism; novel; opioid use; opioid use disorder; pregnant; prenatal stress; psychosocial; recruit; relapse risk; reward circuitry; stress reactivity; stressor; substance use; symptomatology; treatment adherence

Abstract Maternal opioid addiction is a significant public health concern, impacting the health and well-being of both mothers and their developing child during pregnancy and the postpartum period. Crucially, factors shaping maternal opioid use trajectories during pregnancy and after birth are not well understood. Emerging research indicates that elevated levels of psychosocial stress during pregnancy and the first year postpartum may explain increased risk for opioid relapse, consistent with a larger body of research that has documented the role of stress in the initiation and maintenance of addiction generally, and an emerging body of work focusing on parenting stress and addiction specifically. In the current application, we will employ a short-term longitudinal design to probe the biobehavioral mechanisms of psychosocial and parenting stress in pregnant women receiving medication assisted treatment (MAT) for opioid use disorder and demographically-matched pregnant women not receiving MAT. In pregnancy we will measure psychosocial stress and maternal tolerance of infant distress alongside characterizing craving and withdrawal symptoms. After delivery, mothers will complete monthly batteries of assessments to further characterize psychosocial and parenting stress and addiction symptoms. Additionally, mothers will complete neuroimaging assessments at 1 and 4 months postpartum to identify neural mechanisms of responding to infant (and non-infant) distress cues. Our biobehavioral characterization of psychosocial and parenting stress will then be employed in the prediction of MAT adherence. Taken together, this R01 application serves to identify a novel biobehavioral phenotype of psychosocial and parenting stress present in pregnancy and the early postpartum period that may confer increased risk for opioid relapse.

抽象的 母亲阿片类药物成瘾是一个重大的公共卫生问题，影响着双方的健康和福祉 怀孕期间和产后期的母亲及其发育中的孩子。至关重要的是，塑造因素 母亲在怀孕期间和出生后的阿片类药物使用轨迹尚不清楚。新兴研究 表明怀孕期间和产后第一年的社会心理压力水平升高可能会 解释阿片类药物复发的风险增加，这与记录了阿片类药物复发的大量研究一致 压力在成瘾的发生和维持中的作用，以及新兴的工作重点 特别是关于养育压力和成瘾的问题。在当前的应用中，我们将雇佣一个短期的 纵向设计探讨妊娠期心理社会和养育压力的生物行为机制 接受药物辅助治疗 (MAT) 治疗阿片类药物使用障碍且人口统计匹配的女性 未接受 MAT 的孕妇。在怀孕期间，我们将测量社会心理压力和母亲的耐受力 婴儿的痛苦以及渴望和戒断症状的特征。产后，妈妈们会 完成每月的一系列评估，以进一步描述社会心理和养育压力的特征 成瘾症状。此外，母亲将在 1 个月和 4 个月大时完成神经影像学评估 产后确定响应婴儿（和非婴儿）痛苦线索的神经机制。我们的 然后，心理社会和养育压力的生物行为特征将被用于预测 MAT 坚持。总而言之，这个 R01 应用程序用于识别一种新的生物行为表型 怀孕期间和产后早期存在的心理社会和养育压力可能会导致 阿片类药物复发的风险增加。

项目成果

The effects of prenatal stress on neural responses to infant cries in expectant mothers and fathers.

产前压力对准妈妈和准爸爸对婴儿哭闹的神经反应的影响。

• DOI: 10.1002/dev.22280
• 发表时间: 2022
• 期刊: Developmental psychobiology
• 影响因子: 2.2
• 作者: Peoples,SarahG;Lowell,AmandaF;Bunderson,Madison;Bartz,Cody;Yip,SarahW;Rutherford,HelenaJV
• 通讯作者: Rutherford,HelenaJV