Admin Core

管理核心

基本信息

批准号：
10673204
负责人：
PETER D. ADAMS
金额：
$ 35.16万
依托单位：
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673204
关键词：
Acceleration Adherence Aging Atlases Benchmarking Biological Biological Assay Bone Marrow Brain Breast Cell Aging Cell Separation Cells Cellular Assay Cellular biology Clinic Collaborations Colon Communication Data Analyses Data Collection Data Coordinating Center Decision Making Development Ensure Epigenetic Process Experimental Designs Funding Goals Group Meetings Human Individual Infrastructure Institution Leadership Liver Longevity Malignant Neoplasms Maps Monitor Mus Names Performance Persons Policies Procedures Productivity Protocols documentation Recording of previous events Regulation Reporting Research Research Activity Research Personnel Resolution Resource Allocation Resources Role Structure Tissue Banks Travel United States National Institutes of Health Validation data exchange data sharing epigenome epigenomics equipment acquisition experience experimental study flexibility human tissue meetings member multimodality nano-string operation organizational structure programs senescence tissue mapping tissue preparation tool transcriptomics

Acceleration Adherence Aging Atlases Benchmarking Biological Biological Assay Bone Marrow Brain Breast Cell Aging Cell Separation Cells Cellular Assay Cellular biology Clinic Collaborations Colon Communication Data Analyses Data Collection Data Coordinating Center Decision Making Development Ensure Epigenetic Process Experimental Designs Funding Goals Group Meetings Human Individual Infrastructure Institution Leadership Liver Longevity Malignant Neoplasms Maps Monitor Mus Names Performance Persons Policies Procedures Productivity Protocols documentation Recording of previous events Regulation Reporting Research Research Activity Research Personnel Resolution Resource Allocation Resources Role Structure Tissue Banks Travel United States National Institutes of Health Validation data exchange data sharing epigenome epigenomics equipment acquisition experience experimental study flexibility human tissue meetings member multimodality nano-string operation organizational structure programs senescence tissue mapping tissue preparation tool transcriptomics

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项目摘要

PROJECT SUMMARY The central goal of this murine Tissue Mapping Center (TMC) is to produce single cell resolved, multi-modal, and multiscale spatial maps of cellular senescence in murine brain, breast, colon, bone marrow and liver throughout lifespan. The Administrative Core will be responsible for providing the administrative infrastructure necessary for the operation of the Tissue Mapping Center to achieve this overall goal. The Administrative Core will coordinate, evaluate, and provide operational oversight to all components of the research program through actions such as: monitoring overall TMC progress, maintaining scientific rigor, making decisions on milestones and deliverables, allocation of resources and research core effort, equipment acquisition and management, ensuring that team members have requisite support and infrastructure maintained by their host institutions, producing/generating staffing plans, and other policies. In particular, the Core will establish a leadership plan and organizational structure centered around Administration Core Leaders, a Scientific Leadership Team, and a Program Management Team. This structure will facilitate an open, adaptable, and collaborative cycle of discovery and experimental design in support of reaching TMC milestones, as well as facilitate bi-directional interactions with the greater SenNet consortia. The Administrative Core will, through its program management team, coordinate research activities across research cores, including tissue collection, tissue preparation, cell isolation, single-cell assays, spatial assays, data analysis, experimental validation, and interpretation of results by leveraging project management tools and approaches as well as active interaction through regular team meetings, leadership committee meetings, and an annual retreat. The Program Management Team will assess milestone progress on a regular basis, providing reports to the Core Leaders and Scientific Leadership Team. Lastly, the Administrative Core will provide support for the open communication and collaboration with the larger SenNet, including SenNet leadership, NIH, Consortium Organization and Data Coordination Center (CODCC), other SenNet research groups, etc. - as well as provide the underlying administrative infrastructure to ensure the free exchange of data, resources, tools, and ideas. Throughout these activities, the core will ensure adherence to network-wide policies and procedures.

项目摘要这个鼠组织映射中心（TMC）的核心目标是产生分辨的单细胞，多模式，和鼠大脑，乳房，结肠，骨髓和肝脏中细胞衰老的多尺度空间图整个生命周期。行政核心将负责提供行政基础架构组织映射中心的操作必要的才能实现这一总体目标。行政核心通过协调，评估并通过研究计划的所有组成部分进行操作监督诸如：监控TMC的整体进展，保持科学严谨性，对里程碑做出决定以及可交付成果，资源分配和研究核心工作，设备获取和管理，确保团队成员拥有其东道机构维护的必要支持和基础设施，制定/生成人员配备计划和其他政策。特别是，核心将制定领导计划以及围绕行政核心领导者，科学领导团队的组织结构和一个计划管理团队。这种结构将有助于开放，适应性和协作的周期发现和实验设计，以支持达到TMC里程碑，并促进双向与更大的Sennet联盟的相互作用。行政核心将通过其计划管理团队，跨研究核心的研究活动，包括组织收集，组织制备，细胞隔离，单细胞测定，空间测定，数据分析，实验验证和结果解释通过利用项目管理工具和方法以及通过常规团队的积极互动会议，领导委员会会议和年度务虚会。计划管理团队将评估里程碑定期进步，向核心领导者和科学领导团队提供报告。最后，行政核心将为与较大的公开交流和协作提供支持 Sennet，包括Sennet领导力，NIH，财团组织和数据协调中心（CODCC），其他Sennet研究小组等 - 以及提供基本的行政基础设施，以确保免费交换数据，资源，工具和想法。在这些活动中，核心将确保遵守到网络范围的政策和程序。