Clinical core

临床核心

• 批准号: 8718792
• 负责人: ROBERT M JOSEPH
• 金额: $ 51.68万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8718792
• 关键词: Adolescent; Area; Arousal; Behavior; Behavior assessment; Behavioral; Child; Clinical; Clinical Research; Clinical Services; Collaborations; Communication; Communities; Data; Data Collection; Diagnosis; Diagnostic; Enrollment; Ensure; Environment Design; Evaluation; Family; Feedback; Fostering; Goals; Human Resources; Individual; Institutional Review Boards; Instruction; Intervention; Intervention Studies; Investigation; Language; Measures; Morphologic artifacts; Motor Activity; Movement; Outcome; Participant; Peer Review; Phenotype; Preparation; Protocols documentation; Publications; Qualifying; Recruitment Activity; Research; Research Personnel; Secure; Services; Students; Techniques; Testing; Tissue Sample; Training; base; clinical practice; experience; human subject; innovation; neglect; neuroimaging; novel; programs; prospective; screening; success; symposium

The Clinical Core (Core Unit C) will provide a full range of clinical services to the ACE. The services include recruitment, diagnosis and comprehensive behavioral assessments of participants for Projects I, II, and 111. Core personnel will provide assistance in outcome evaluations for Project I and data collection for Projects 11 and III and will maintain communications and support for participants and their families. In addition, Core C will provide advice and interpretation of available phenotyping information for the tissue samples that will be available for Project IV. The Core personnel includes highly qualified clinicians and researchers covering a range of professional expertise, as well as students and staff who will be trained in carrying out the assessments and fulfilling the goals of the Core and the Center. Because many of the participants to be recruited for the Center projects present with highly challenging behaviors and are difficult to test, a number of innovative approaches will be taken to maximize participants' success in completing the behavioral assessments, and then to tolerate and provide artifact-free data in the electrophysiological (Project 11) and neuroimaging (Project III) studies. Novel measures for assessing key behavioral domains (including movements and motor activity; autonomic arousal; vocal behavior; language) across different contexts will be included. The clinical core will provide detailed preparation and support for the staff and families that will be implemented through a secure on-line environment designed to deliver video-based training and foster communication and collaboration between the research programs and participating families. The primary goal is to ensure that high quality clinical and research data will be collected and that participants and their families find their involvement with our research center a supportive and satisfying experience.

临床核心（核心单元 C）将为 ACE 提供全方位的临床服务。这些服务包括项目 I、II 和 111 参与者的招募、诊断和综合行为评估。 核心人员将为项目一的成果评估和项目11和项目三的数据收集提供帮助，并将为参与者及其家人保持沟通和支持。此外，核心 C 将为项目 IV 提供的组织样本的可用表型信息提供建议和解释。核心人员包括高素质的临床医生和研究人员，涵盖 一系列专业知识，以及将接受培训以进行评估和实现核心和中心目标的学生和工作人员。由于该中心项目招募的许多参与者都表现出极具挑战性的行为并且难以测试，因此将采取许多创新方法来最大限度地提高参与者完成行为评估的成功率，然后容忍并提供工件-电生理学（项目 11）的免费数据和 神经影像（项目 III）研究。将包括评估不同背景下关键行为领域（包括运动和运动活动、自主唤醒、发声行为、语言）的新措施。临床核心将为工作人员和家庭提供详细的准备和支持，这些准备和支持将通过安全的在线环境实施，旨在提供基于视频的培训并促进研究项目和参与家庭之间的沟通与合作。初级 目标是确保收集高质量的临床和研究数据，并确保参与者及其家人发现他们参与我们的研究中心是一种支持和令人满意的经历。