Interaction of physical activity and sleep in early childhood and their influence on cognition and the hippocampus

幼儿期身体活动和睡眠的相互作用及其对认知和海马体的影响

基本信息

批准号：
10682034
负责人：
Christine Woodward St. Laurent
金额：
$ 0.25万
依托单位：
UNIVERSITY OF MASSACHUSETTS AMHERST
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-11 至 2023-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10682034
关键词：
6 year old Accelerometer Accounting Address Adult Affect Age American Behavior Brain Brain region Child Clinical Trials Cognition Cognitive Communities Cross-Sectional Studies Data Data Analyses Development Development Plans Education Enrollment Epidemiology Family Practice Fellowship Foundations Funding Future Goals Guidelines Habits Health behavior Hippocampus (Brain)Infant Intervention Intervention Studies Journals Learning Level of Evidence Light Longevity Longitudinal Studies Magnetic Resonance Imaging Manuscripts Measurement Measures Memory Mental Health Mentorship Methods Monitor Movement Napping Nature Neurocognitive Nursery Schools Outcome Participant Pattern Peer Review Performance Physical activity Policies Population Public Health Reporting Research Research Personnel Research Training Schools Science Sleep Socioeconomic Status Statistical Data Interpretation Structure Subgroup Time Toddler Training Training Activity Underserved Population United States National Institutes of Health Vocabulary Work Wrist Writing actigraphy aged base career cognitive development cognitive function cognitive performance critical developmental period critical period design early childhood executive function innovation insight longitudinal analysis longitudinal design moderate-to-vigorous physical activity neurodevelopment physical conditioning sedentary sedentary lifestyle sleep behavior systematic review time use

项目摘要

PROJECT SUMMARY Although physical activity, sedentary behavior, and sleep (i.e., 24-hr behaviors) have been associated with cognitive and brain outcomes in older children and adults, studies are limited in early childhood and typically examine these behaviors separately. Given that early childhood serves as an important time for brain and cognitive development and when healthy habits (i.e., low sedentary time, high physical activity, and sufficient sleep) are formed, the goal of this research is to examine the relations between 24-hr behaviors, cognition, and brain structure (i.e., hippocampal volume, as this structure is a key brain region to learning and memory) in early childhood. The aims of this proposal are to determine if 24-hr behaviors are associated with 1) cognitive performance and 2) hippocampal volume in early childhood. Data from two ongoing studies examining the benefits of napping on memory in early childhood (i.e., children ages 33 to 71 months) will be used: a clinical trial (NIH R01 HL111695) with one measurement period and a longitudinal clinical trial (NIH R21 HD094758/NSF 1749280) with three measurement periods over one year. To address the aims of this project, cross-sectional and longitudinal analyses from various subgroups of participants of the two studies will be conducted. Measurements will include time spent in each of the 24-hr behaviors from 16-days of actigraphy (i.e., accelerometry via a wrist monitor), cognitive performance from multiple assessments, and hippocampal volume from magnetic resonance imaging. The aims of this proposal have public health significance in that they will identify potential windows of opportunity to intervene on health behaviors, learning, and cognitive function at a critical developmental period of the lifespan. The findings can inform future intervention studies, family practices, early childhood education policies, and comprehensive guidelines for a 24-hr cycle. Collectively, the proposed development plan incorporates activities for training in developmental science, sleep, neurocognitive measurement, statistical analyses, and scientific writing. Successful completion of this proposed training plan will result in several submissions of first-author manuscripts to peer-reviewed journals and an essential research foundation to support a competitive early career funding proposal. The fellowship will provide protected time and unique cross-disciplinary mentorship for successful completion of research and training goals.

项目摘要尽管体育锻炼，久坐行为和睡眠（即24小时行为）与年龄较大的儿童和成人的认知和大脑结果，研究在幼儿时期受到限制，通常是分别检查这些行为。鉴于幼儿时期是大脑和认知发展及其健康习惯（即低久坐时间，体育锻炼高和足够的时间形成睡眠），这项研究的目的是检查24小时行为，认知和大脑结构（即海马体积，因为这种结构是学习和记忆的关键大脑区域）童年。该提案的目的是确定24小时行为是否与1）认知有关性能和2）幼儿时期的海马体积。来自两项正在进行的研究的数据检查童年时期的记忆的好处（即33至71个月的儿童）将使用：临床试验（NIH R01 HL111695）具有一个测量期和纵向临床试验（NIH R21 HD094758/NSF） 1749280）在一年内有三个测量期。为了解决该项目的目的，横截面将进行两项研究的参与者的各个亚组的纵向分析。测量值将包括从16天行为的24小时行为中花费的时间（即通过腕部监视器的加速度计），多次评估的认知性能以及海马体积来自磁共振成像。该提案的目的具有公共卫生意义，因为他们将确定潜在的机会窗口，以干预健康行为，学习和认知功能生命周期的关键发展时期。这些发现可以为未来的干预研究，家庭实践，幼儿教育政策和24小时周期的综合指南。共同提议开发计划纳入了开发科学，睡眠，神经认知培训的活动测量，统计分析和科学写作。成功完成了该建议的培训计划将导致一些提交的第一名撰稿人手稿，以进行同行评审的期刊和一项基本的研究支持竞争激烈的早期职业资金建议。奖学金将提供受保护的时间，成功完成研究和培训目标的独特跨学科指导。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Influence of naps on sedentary time and physical activity in early childhood.

DOI：
10.1038/s41598-022-25628-x
发表时间：
2022-12-08
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
Laurent, Christine St. W.;Lokhandwala, Sanna;Allard, Tamara;Ji, Angela;Riggins, Tracy;Spencer, Rebecca M. C.
通讯作者：
Spencer, Rebecca M. C.

Temporal Associations between Actigraphy-Measured Daytime Movement Behaviors and Nap Sleep in Early Childhood.