Advanced Imaging and Dosimetry Core

先进的成像和剂量测定核心

基本信息

批准号：
10672961
负责人：
Bryan Patrick Bednarz
金额：
$ 28.87万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-14 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10672961
关键词：
3-Dimensional Animals Bioinformatics Biometry Calibration Cancer Center Cancer Model Clinical Collaborations Combined Modality Therapy Communities Computational algorithm Computer software Data Dedications Deposition Discipline of Nuclear Medicine Dose Drug Kinetics Emission-Computed Tomography Ensure Equipment Experimental Designs Funding Goals Human Image Image Analysis Immunologic Stimulation Immunologics Immunosuppression Immunotherapy Individual Infrastructure Lead Leadership Magnetic Resonance Malignant Neoplasms Maps Medical Medical Research Modeling Molecular Target National Cancer Institute Normal tissue morphology Patient Selection Patient-Focused Outcomes Patients Pharmaceutical Preparations Physics Positron-Emission Tomography Process Production Protocols documentation Publications Quality Control Radiation therapy Radiochemistry Radioisotopes Radionuclide therapy Radiopharmaceuticals Renaissance Reporting Research Research Personnel Resources Rodent Scanning Services Therapeutic Time Toxic effect Translating Treatment Efficacy Tumor Tissue Uncertainty United States Food and Drug Administration University of Wisconsin Comprehensive Cancer Center University resources Wisconsin X-Ray Computed Tomography absorption animal imaging clinical translation companion animal cost efficient dosimetry drug distribution experience imaging facilities immunomodulatory strategy immunoregulation improved individualized medicine next generation operation optical imaging professor quality assurance quantitative imaging response symposium synergism theranostics treatment planning treatment response tumor tumor microenvironment

项目摘要

PROJECT SUMMARY The Advanced Imaging and Dosimetry Core (AIDC) provides the infrastructure, resources, and expertise required to facilitate quantitative multiscale imaging and dosimetry calculations, which are required to optimally synergize the combination of molecular targeted radionuclide therapy (TRT) and immunotherapy (ImmRx). The AIDC is a centralized dosimetry service that will ensure consistent scientific rigor and dosimetry reporting across each of the Projects of this PO1 proposal, entitled “Molecular targeted radionuclide therapy for tumor immunomodulation and enhancing immunotherapy response”. Furthermore, the significance of centralizing this process for each Project is the tremendous gain in efficiency that are achieved, ultimately saving individual investigators time and effort. Additionally, the AIDC will expand the leadership and operation of the Small Animal Imaging and Radiotherapy Facility (SAIRF) by offering support in all stages of the imaging and TRT dosimetry process, including calibration, experimental design, image acquisition optimization, pharmacokinetic profiling and modeling, micro-and macroscopic 3D dose calculations, and treatment response assessment. The AIDC will emphasize quality assurance and quality control in all aspects of the imaging and dosimetry process so that results are validated for application to the FDA. The AIDC will collaborate closely with the Radionuclide Production and Radiochemistry Core (RPRC) for dose calibration and traceability of the radiopharmaceuticals; and, the AIDC will collaborate with the Biostatistics and Bioinformatics Core (BBC) to help interpret imaging and dosimetry findings to validate response assessment. Lastly, the AIDC will help investigators disseminate their findings to the scientific community through publications and conference presentations. Renowned experts in the field of TRT dosimetry, Professor Bryan Bednarz and Joseph Grudzinski, will lead administrative and technical efforts, respectively.

项目摘要高级成像和剂量测定核心（AIDC）提供基础架构，资源和专业知识需要促进定量多尺度成像和剂量计计算，这是最佳的协同分子靶向放射性治疗（TRT）和免疫疗法（IMMRX）的结合。这 AIDC是一项集中式剂量法服务，可确保跨越科学严格和剂量计的报告该PO1提案的每个项目，标题为“分子靶向放射线治疗肿瘤免疫调节和增强免疫疗法反应”。此外，集中的意义每个项目的过程都是实现效率的巨大提高，最终拯救了个人调查人员的时间和精力。此外，AIDC将扩大小动物的领导和运作成像和放射疗法设施（SAIRF）通过在成像和TRT剂量测定阶段提供支持过程，包括校准，实验设计，图像采集优化，药代动力学分析以及建模，微观和宏观3D剂量计算以及治疗反应评估。这 AIDC将在成像和剂量测定过程的各个方面强调质量保证和质量控制因此，该结果将被验证以应用于FDA。 AIDC将与Radiouclide紧密合作用于放射性药物的剂量校准和可追溯性的生产和放射化学核心（RPRC）；而且，AIDC将与生物统计学和生物信息学核心（BBC）合作，以帮助解释成像和剂量测定结果以验证响应评估。最后，AIDC将帮助调查人员传播他们的通过出版物和会议演讲向科学界的发现。重新拥有的专家 TRT剂量学领域，Bryan Bednarz教授和Joseph Grudzinski将领导行政和技术努力分别。