Epidemiology of Infectious Diseases

传染病流行病学

• 批准号: 10476268
• 负责人: Albert Hofman
• 金额: $ 35.52万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10476268
• 关键词: Infectious Disease Epidemiology

Project Summary Despite progress in prevention and treatment by sanitation, antimicrobials, vaccines, and other measures, infectious diseases still threaten life and health. In 2016, communicable diseases accounted for over 17% of disability-adjusted life years lost worldwide. With globalization, infectious disease threats (previously seen as being limited to less-developed countries) threaten everyone (like Ebola, HIV, MERS, pandemic influenza, and growing resistance to antimicrobial drugs). The combination of computational power and “Big Data” provides a new opportunity to study infectious diseases and their transmission through novel approaches, necessitating new sophistication in the training of infectious disease epidemiologists. We recognize the need for a corps of academic and government epidemiologists, equipped to deploy sophisticated approaches to causal inference, transmission-dynamic modeling, model fitting using MCMC and other Bayesian techniques, population genomics, phylogenetics, and other novel techniques. The goal of Harvard Chan School of Public Health’s (HSPH) Interdisciplinary Program in Infectious Disease Epidemiology (IPIDE) is to train graduates who can apply these diverse tools to meet the infectious disease threats of a new generation. Our training faculty includes leading practitioners of all of these techniques and our recent graduates are emerging with deep training, research experience, and publications in many of these areas. The training program includes coursework in epidemiology, drug resistance, and mathematical modeling of disease from IPIDE under the close supervision of our 25 faculty mentors, leading either to a DSc or a PhD. A tremendously successful postdoctoral training program has to date relied on research funding. Harvard’s IPIDE has been running successfully for 20 years, and this training grant has helped develop not only a new cadre of students with the capacity to monitor, prevent, and suppress diverse emerging infectious diseases but has also allowed IPIDE to expand its faculty, funding, diversity of research, and, the number of students who join the infectious disease epidemiology program. Over the past ten years, 23 trainees have been supported, 18 graduated, and they published 581 peer-reviewed manuscripts (177 first author publications). For the current submission, we propose to support 5 pre-doc and 2 post-doctoral trainees each year over the next five-year project period. Adding these postdoctoral positions will realize synergies and collaborative opportunities between pre- and postdoctoral fellows and create the opportunity to build new means of integrating postdocs into the highly interdisciplinary training environment.

项目概要 尽管通过卫生、抗菌药物、疫苗和其他方法在预防和治疗方面取得了进展 2016年，传染病仍然威胁着生命和健康。 随着全球化的发展，全球损失的伤残调整寿命年中，有超过 17% 是由这一因素造成的。 传染病威胁（以前被认为仅限于欠发达国家）危险 每个人（例如埃博拉病毒、艾滋病毒、中东呼吸综合征、大流行性流感以及日益增长的抗菌药物耐药性） ）计算药物能力与“大数据”的结合提供了新的机会。 通过新方法研究传染病及其传播，需要新的方法 我们认识到需要对传染病流行病学家进行培训。 由学术界和政府流行病学家组成的队伍，有能力部署先进的 使用 MCMC 进行因果推理、传输动态建模、模型拟合的方法 其他贝叶斯技术、群体基因组学、系统发育学和其他新技术。 哈佛大学陈公共卫生学院 (HSPH) 跨学科项目的目标 传染病流行病学（IPIDE）旨在培养能够应用这些不同工具的毕业生 应对新一代传染病的威胁 我们的培训师资队伍包括领先的人员。 所有这些技术的照顾者和我们最近的毕业生正在接受深入的培训， 培训计划包括许多这些领域的研究经验和出版物。 IPIDE 的流行病学、耐药性和疾病数学建模课程 在我们 25 名教师导师的密切监督下，获得理学硕士或博士学位。 迄今为止，博士后培训计划取得的巨大成功依赖于研究经费。 哈佛大学的IPIDE已经成功运行了20年，这笔培训资助 不仅帮助培养了一支有能力监测、预防和 抑制各种新出现的传染病，同时也使 IPIDE 能够扩大其师资队伍， 资金、研究的多样性以及参加传染病研究的学生数量 十年来，资助了23名学员，18名学员毕业， 他们发表了 581 篇经过同行评审的手稿（177 篇第一作者出版物）。 根据提交的材料，我们建议每年支持 5 名博士前培训生和 2 名博士后培训生 下一个五年项目期间增加这些博士后职位将实现协同效应和 博士前和博士后研究员之间的合作机会，并创造机会 建立将博士后融入高度跨学科培训环境的新方法。