Epidemiology of Infectious Diseases

传染病流行病学

• 批准号: 10656475
• 负责人: Albert Hofman
• 金额: $ 36.32万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656475
• 关键词: Infectious Disease Epidemiology

Project Summary Despite progress in prevention and treatment by sanitation, antimicrobials, vaccines, and other measures, infectious diseases still threaten life and health. In 2016, communicable diseases accounted for over 17% of disability-adjusted life years lost worldwide. With globalization, infectious disease threats (previously seen as being limited to less-developed countries) threaten everyone (like Ebola, HIV, MERS, pandemic influenza, and growing resistance to antimicrobial drugs). The combination of computational power and “Big Data” provides a new opportunity to study infectious diseases and their transmission through novel approaches, necessitating new sophistication in the training of infectious disease epidemiologists. We recognize the need for a corps of academic and government epidemiologists, equipped to deploy sophisticated approaches to causal inference, transmission-dynamic modeling, model fitting using MCMC and other Bayesian techniques, population genomics, phylogenetics, and other novel techniques. The goal of Harvard Chan School of Public Health’s (HSPH) Interdisciplinary Program in Infectious Disease Epidemiology (IPIDE) is to train graduates who can apply these diverse tools to meet the infectious disease threats of a new generation. Our training faculty includes leading practitioners of all of these techniques and our recent graduates are emerging with deep training, research experience, and publications in many of these areas. The training program includes coursework in epidemiology, drug resistance, and mathematical modeling of disease from IPIDE under the close supervision of our 25 faculty mentors, leading either to a DSc or a PhD. A tremendously successful postdoctoral training program has to date relied on research funding. Harvard’s IPIDE has been running successfully for 20 years, and this training grant has helped develop not only a new cadre of students with the capacity to monitor, prevent, and suppress diverse emerging infectious diseases but has also allowed IPIDE to expand its faculty, funding, diversity of research, and, the number of students who join the infectious disease epidemiology program. Over the past ten years, 23 trainees have been supported, 18 graduated, and they published 581 peer-reviewed manuscripts (177 first author publications). For the current submission, we propose to support 5 pre-doc and 2 post-doctoral trainees each year over the next five-year project period. Adding these postdoctoral positions will realize synergies and collaborative opportunities between pre- and postdoctoral fellows and create the opportunity to build new means of integrating postdocs into the highly interdisciplinary training environment.

项目摘要 尽管在卫生方面进行预防和治疗方面取得了进展，但抗菌素，疫苗和其他 措施，传染病仍然威胁着生活和健康。在2016年，传播的疾病 在全球范围内损失的残疾调整后的生活年占17％以上。随着全球化， 传染病威胁（以前被视为仅限于欠发达国家）威胁 每个人（例如埃博拉病毒，艾滋病毒，梅尔斯，大流行影响力以及对抗菌剂的抗药性 药物）。计算能力和“大数据”的结合为新的机会提供了新的机会 研究传染病及其通过新方法的传播，必要的新方法 我们认识到需要接受传染病流行病学家培训的培训。 学术和政府流行病学家，能够部署复杂的 因果推断，传播动力建模，使用MCMC和MCMC的模型拟合的方法 其他贝叶斯技术，种群基因组学，系统发育学和其他新技术。 哈佛大学公共卫生学院（HSPH）跨学科计划的目标 传染病流行病学（iPide）是培训可以应用这些不同工具的毕业生 应对新一代的传染病威胁。我们的培训教师包括领导 所有这些技术和我们最近的毕业生的从业者正在深入培训， 研究经验和许多领域的出版物。培训计划包括 iPide的流行病学，耐药性和数学建模的课程工作 在我们的25位教师导师的密切监督下，导致了DSC或博士学位。 迄今为止，在研究资金中救出了巨大成功的博士后培训计划。 哈佛大学的iPide已经成功运行了20年，这项培训赠款已有 不仅有助于开发新的学生干部，并有能力监视，预防和 抑制潜水员新兴的传染病，但也允许ipide扩大其教师， 资金，研究多样性以及加入传染病的学生人数 流行病学计划。在过去的十年中，有23名学员得到了支持，有18名毕业 他们出版了581个同行评审的手稿（177个第一作者出版物）。对于电流 提交，我们建议每年在 下一个五年期。添加这些博士后职位将实现协同作用，并且 前和博士后研究员之间的协作机会，并创造机会 建立将博士后集成到高度跨学科培训环境中的新方法。

项目成果

Food insufficiency is a risk factor for suboptimal antiretroviral therapy adherence among HIV-infected adults in urban Peru.

• DOI: 10.1007/s10461-010-9789-6
• 发表时间: 2011-10
• 期刊: AIDS AND BEHAVIOR
• 影响因子: 4.4
• 作者: Franke, Molly F.;Murray, Megan B.;Munoz, Maribel;Hernandez-Diaz, Sonia;Luis Sebastian, Jose;Atwood, Sidney;Caldas, Adolfo;Bayona, Jaime;Shin, Sonya S.
• 通讯作者: Shin, Sonya S.

Frequency-dependent selection can forecast evolution in Streptococcus pneumoniae.

• DOI: 10.1371/journal.pbio.3000878
• 发表时间: 2020-10
• 期刊: PLoS biology
• 影响因子: 9.8
• 作者: Azarian T;Martinez PP;Arnold BJ;Qiu X;Grant LR;Corander J;Fraser C;Croucher NJ;Hammitt LL;Reid R;Santosham M;Weatherholtz RC;Bentley SD;O'Brien KL;Lipsitch M;Hanage WP
• 通讯作者: Hanage WP

Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication.

• DOI: 10.1056/nejmoa2109449
• 发表时间: 2022-01-06
• 期刊: The New England journal of medicine
• 作者: John LN;Beiras CG;Houinei W;Medappa M;Sabok M;Kolmau R;Jonathan E;Maika E;Wangi JK;Pospíšilová P;Šmajs D;Ouchi D;Galván-Femenía I;Beale MA;Giacani L;Clotet B;Mooring EQ;Marks M;Vall-Mayans M;Mitjà O
• 通讯作者: Mitjà O

Adherence to post-exposure prophylaxis for non-forcible sexual exposure to HIV: a systematic review and meta-analysis.

遵守暴露后的预防性对艾滋病毒的性暴露：系统评价和荟萃分析。

• DOI: 10.1007/s10461-013-0567-0
• 发表时间: 2014-02
• 期刊: AIDS AND BEHAVIOR
• 影响因子: 4.4
• 作者: Oldenburg, Catherine E.;Baernighausen, Till;Harling, Guy;Mimiaga, Matthew J.;Mayer, Kenneth H.
• 通讯作者: Mayer, Kenneth H.

Spatiotemporal Trends in Group A Streptococcal Pharyngitis in the United States.

美国 A 组链球菌性咽炎的时空趋势。

• DOI: 10.1101/2023.11.16.23298647
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Kline,MadeleineC;Kissler,StephenM;Whittles,LilithK;Barnett,MichaelL;Grad,YonatanH
• 通讯作者: Grad,YonatanH