Obesity Prevention Targets for Down Syndrome

唐氏综合症的肥胖预防目标

• 批准号: 10696074
• 负责人: Lisa Ann Daunhauer
• 金额: $ 66.7万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-03 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10696074
• 关键词: 6 year old; Adult; Affect; Age; Attention; Birth; Body Weight; Caregivers; Child; Childhood; Chronology; Clinical Data; Collection; Congenital Heart Defects; Data; Development; Diagnosis; Diet; Dietary intake; Disease; Down Syndrome; Early identification; Energy Intake; Enrollment; Ensure; Family; Family dynamics; General Population; Goals; Growth; Health; Height; Hypothyroidism; Individual; Intake; Intellectual functioning disability; Knowledge; Learning; Life Expectancy; Longevity; Macronutrients Nutrition; Measures; Medical; Medical History; Modeling; Motor; Motor Skills; Obesity; Obesity Epidemic; Obstructive Sleep Apnea; Outcome; Overweight; Participant; Personal Satisfaction; Persons; Phenotype; Physical activity; Prevalence; Prevention; Probability; Proxy; Reporting; Research; Research Personnel; Risk; Risk Factors; Risk Reduction; Sampling; Science; Seasons; Site; Sleep; Time; Toddler; Underserved Population; United States National Institutes of Health; Visit; Walking; Weight; Weight Gain; aged; aspirate; caregiving; dietary; early childhood; experience; feeding; follow-up; foot; high risk; high risk population; improved; individual variation; longitudinal design; neurogenetics; non-alcoholic fatty liver disease; nutrition; obese person; obesity in children; obesity prevention; obesity risk; overweight child; primary caregiver; prospective; protective factors; recruit; resilience factor; sex; skill acquisition; social

PROJECT SUMMARY ABSTRACT Children with Down syndrome (DS) are disproportionately affected by the obesity epidemic, presenting a prevention challenge that is currently unmet. Despite improved life expectancies, people with DS experience poor health.10 Children and adults with DS have significantly higher rates of overweight/obesity (OW/OB) than those with intellectual disability from other causes11 or the general population.12 These risks are rooted in childhood, with rapid increases in OW/OB observed between ages 2 and 6 years in children with DS2–4 and childhood OW/OB conferring a higher risk for OW/OB in adulthood.2,3 However, research examining young children with DS+OW/OB has primarily focused on prevalence rates using retrospective clinical data, with minimal attention to modifiable prevention targets.2,11,13 Consequently, critical questions regarding how DS phenotypic factors such as co-occurring conditions, motor delays, and feeding challenges contribute to OW/OB risk remain unanswered. Despite being a specific, high-risk population for obesity, no prospective, longitudinal DS research has comprehensively characterized OW/OB predictors to guide effective prevention in early childhood when such efforts may enhance downstream health outcomes. Bridging this knowledge gap recently highlighted by prominent DS researchers,18 our team representing expertise in early development in DS, nutrition, and obesity in DS, physical activity (PA), and sleep, will use a longitudinal design to identify early OW/OB prevention targets for young children with DS. Using a staggered wave approach, we will enroll and assess 1/3 of the sample in Wave 1/Y1, with annual follow-up visits (+ 1 month) in Y2&3, using the same approach for Wave 2 (Y2-4) and Wave 3 (Y3-5), thus reducing recruitment demands over time and sites (total project n=160). At T1-3, we will collect data on (a) child factors—objectively measured PA, motor abilities (gross, fine, motor planning), sleep, and weight/height, plus caregiver-reported child dietary intake (energy, macronutrients, and dietary quality), child developmental and medical history, and feeding abilities; and (b) caregiving factors—caregiver feeding and PA practices, family dynamics, caregiver weight/height, and SES. At T1, we will recruit caregivers and their child with DS chronological ages 18-40 months, who walk 15+ feet independently. The age range ensures participant ages align with: (1) the full range of developmental variability expected in children with DS given that 95% of children with DS reach this walking milestone between 18-40 months (median = 24 months),5 and (2) observed weight gain increases between 2 to 6 years of age in DS,2–4 with 4-6 year-olds 61% more likely to have OB than those aged 2-3 years.2 The overarching project goal is to understand variability in risks for OW/OB in DS and identify prevention targets in young children with DS. Our long-term goal is to develop and deliver obesity prevention in early childhood to reduce risks for OW/OB and associated medical sequelae across the lifespan for individuals with DS.

项目摘要摘要 唐氏综合症（DS）的儿童受肥胖症流行的影响不成比例 目前未满足的预防挑战。尽管预期寿命提高了，但具有DS经验的人 健康状况不佳。10DS儿童和成人的超重/肥胖（OW/OB）的比率明显高于 从其他原因或普通人群中有智力残疾的人。12这些风险植根于 童年时期，DS2-4和 童年时代/ob会议在成年期间有更高的OW/ob风险。2,3但是，研究年轻的研究 DS+OW/OB的儿童主要专注于使用回顾性临床数据的患病率， 对可修改的预防目标的关注最少。2,11,13因此，有关DS的关键问题 表型因素，例如共发生条件，运动延迟和喂养挑战，有助于OW/OB 风险仍未得到答复。 Despite being a specific, high-risk population for obesity, no prospective, 纵向DS研究已全面表征了OW/OB预测因子，以指导有效 幼儿期预防这种努力可能会增强下游健康结果。桥接 著名DS研究人员最近强调了这一知识差距，18我们的团队代表早期专业知识 DS，营养和肥胖的发展DS，体育锻炼（PA）和睡眠，将使用纵向设计 确定DS幼儿的早期OW/OB预防目标。使用交错的波浪方法，我们 将在第1次/Y1中注册和评估样本的1/3，使用Y2和3的年随访（+ 1个月） 第2波（Y2-4）和Wave 3（Y3-5）的相同方法，因此随着时间的推移而减少了招聘需求 站点（总项目n = 160）。在T1-3时，我们将收集有关（a）儿童因素的数据 - 目标测量的PA，电动机 能力（总体，精细，运动计划），睡眠和体重/身高，以及照顾者报告的儿童饮食摄入量 （能量，大量营养素和饮食质量），儿童发育和病史以及喂养能力；和 （b）护理因素 - 照顾者喂养和PA实践，家庭动态，护理人员体重/身高以及SES。 在T1，我们将招募18-40个月的DS年代的护理人员和他们的孩子，他们步行15英尺以上 独立。年龄范围可确保参与者年龄与以下方式保持一致：（1）发育变异性的全部范围 鉴于有95％的DS儿童达到18-40之间的步行里程碑，预计在DS的儿童中预计 月份（中位数= 24个月），5和（2）观察到的体重增加在DS的2至6岁之间增加2-4岁 与2-3岁的OB相比，有4-6岁的年龄较高61％。2总体项目目标是 了解DS中OW/OB风险的可变性，并确定DS幼儿的预防目标。我们的 长期目标是在幼儿期开发和提供预防肥胖，以降低OW/OB和 DS个体的整个寿命中的相关医学后遗症。