Translational Pulmonary Vascular Biology

转化肺血管生物学

• 批准号: 8828282
• 负责人: Mark T Gladwin
• 金额: $ 18.87万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8828282
• 关键词: Biology; Blood Vessels; Lung

DESCRIPTION (provided by applicant): Biomedical investigators are witnessing a limitation in our collective ability to translate the remarkable basic science discoveries of the current era to the clinic. The divide between basic discovery and clinical application has been appropriately termed "the valley of death". A dearth of both physician scientists focused on translational research and lack of training programs creatively focused on translational research methodologies compound this problem. The aim of this program is to develop a novel training program in bench-to-bedside research methodology and to train the future generation of clinical and basic researchers in a translational approach to vascular biology, with a specific emphasis on the pulmonary circulation. While there are many T32 programs focused on systemic vascular biology, to our knowledge there is not a single program focused on Pulmonary Vascular Biology and Pulmonary hypertension. We have engineered a new approach to training in translational bench-to-bedside research, focused on providing the trainee with a "translational research core competency tool-set", starting with immersion in a concentrated training period in translational research, that includes novel elective one-month rotations focused on pulmonary hypertension therapeutics at the FDA, intramural NIH Clinical Center Regulatory and Pharmacy Development Program, and Industry. With the fundamental tools for human subjects research in hand the trainee will then engage in a two-year intensive training fellowship with our translationally-oriented vascular biology and pulmonary hypertension mentors. The fellowship mentorship will include a basic-science oriented mentor paired with a clinical-science oriented mentor to provide for comprehensive training in basic science with the necessary application to the clinical and patient environment. Projects are focused on patient oriented bench-to-bedside (T1) research, with constant attention to trainee career development. Our faculty include 19 NIH funded investigators with a long- standing history of scientific productivity in pulmonary vascular biolog and successful mentoring. We also include 4 junior training faculty who are highly focused on pulmonary vascular research, are recent recipients of R-level NIH funding, and will be paired with senior mentors to maintain a continuous pipeline of faculty mentors. Substantial institutional support and resources are available through endowments to the VMI and a translational program project directed by Dr. Gladwin. The field of Pulmonary Vascular Biology has matured to the point that we can no longer rely on "back door" training for the next generation of pulmonary vascular researchers. The proposed training program and the existing investigators and infrastructure at The University of Pittsburgh are strongly positioned to create a novel and rich bench-to-bedside translational training program, designed to address the growing and severe "valley of death" between basic research discoveries and clinical application.

描述（由申请人提供）：生物医学研究人员正在目睹我们将当今时代卓越的基础科学发现转化为临床的集体能力的局限性。基础发现和临床应用之间的鸿沟被恰当地称为“死亡之谷”。缺乏专注于转化研究的医师科学家，以及缺乏创造性地专注于转化研究方法的培训项目，加剧了这个问题。该计划的目的是开发一种新颖的从实验室到临床研究方法的培训计划，并培训下一代临床和基础研究人员采用血管生物学的转化方法，特别强调肺循环。虽然有许多 T32 项目专注于系统血管生物学，但据我们所知，没有一个项目专注于肺血管生物学和肺动脉高压。我们设计了一种新的转化实验室到临床研究培训方法，重点是为学员提供“转化研究核心能力工具集”，从沉浸在转化研究的集中培训阶段开始，其中包括新颖的选修课为期一个月的轮换重点是 FDA、NIH 临床中心监管和药房开发项目以及行业内的肺动脉高压治疗。掌握了人体研究的基本工具后，学员将与我们以转化为导向的血管生物学和肺动脉高压导师一起参加为期两年的强化培训。奖学金导师将包括一名基础科学导向的导师和一名临床科学导向的导师，以提供基础科学的全面培训，并将其应用于临床和患者环境。项目侧重于以患者为导向的实验室到临床 (T1) 研究，并持续关注学员的职业发展。我们的教员包括 19 名 NIH 资助的研究人员，他们在肺血管生物学领域具有悠久的科学生产力和成功的指导历史。我们还包括 4 名初级培训教师，他们高度专注于肺血管研究，最近获得了 R 级 NIH 资助，并将与高级导师配对，以维持教师导师的持续输送。实质性机构 通过对 VMI 的捐赠和 Gladwin 博士指导的转化计划项目可以获得支持和资源。肺血管生物学领域已经成熟到我们不能再依赖下一代肺血管研究人员的“后门”培训。拟议的培训计划以及匹兹堡大学现有的研究人员和基础设施有能力创建一个新颖且丰富的从实验室到临床的转化培训计划，旨在解决基础研究发现与临床研究之间日益严重的“死亡之谷”问题。临床应用。