The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection)

DECREASE SSI 试验（去殖民化以减少手术部位感染的术后事件）

• 批准号: 10670860
• 负责人: STUART H. COHEN
• 金额: $ 50万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670860
• 关键词: DECREASE; SSI; Trial; Decolonization; Reduce

Abstract The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) Colon and small bowel surgery are high-volume, high-cost surgeries performed in over 675,000 patients in the United States each year. These surgeries carry one of the highest surgical site infection (SSI) rates, with estimates of 11-45%, or 2- to 3-fold higher than nationally reported rates, when comprehensive surveillance efforts are used, such as in clinical trials. Comprehensive tracking also uncovers a disproportionate amount of post-discharge incisional SSIs. These incisional SSIs are strongly tied to patient anxiety, stress, embarrassment, dissatisfaction, and lower quality of life scores. Mounting evidence shows that social and economic disadvantage can adversely affect the risk of SSI, likely due to the differential ability to protect a fresh incision from infection after hospital discharge. The Decolonization to Reduce After-Surgery Events of Surgical Site Infection (DECREASE SSI) Trial will test the value of adding a post-operative intervention to current pre-operative and intra-operative prevention practices. The DECREASE SSI Trial is a multi-site pragmatic randomized controlled clinical trial comparing routine post- discharge wound care to a post-discharge decolonization regimen of chlorhexidine bathing and nasal iodophor to prevent SSI events in the 30 days following discharge for open colon and small bowel surgery. If successful, this trial will provide a simple prevention measure for the 675,000 persons who undergo non-laparoscopic surgery involving the small and large intestines each year.

抽象的 减少SSI试验（非殖民化以减少手术部位感染的术后事件） 结肠和小肠手术是高体积的高成本手术 每年在美国的患者。这些手术带有最高的手术部位感染之一（SSI）之一 估计估计为11-45％，或比全国报道的利率高2至3倍 使用监视工作，例如在临床试验中。全面的跟踪也发现了 分配后切口SSI的数量不成比例。这些切开的SSI与患者密切相关 焦虑，压力，尴尬，不满和生活质量得分较低。 越来越多的证据表明，社会和经济劣势可能会对SSI的风险产生不利影响， 可能是由于保护新切口在出院后免受感染的能力差异所致。这 非殖民化以减少手术部位感染的外科手术事件（减少SSI）试验将测试 将术后干预措施添加到当前术前和术中预防实践中的价值。 SSI降低试验是一项多站点务实的随机对照临床试验，比较了常规后 排出伤口护理到氯己定沐浴和鼻腔碘载体的分离后非殖民化方案 为了防止在出院后的30天内进行开放结肠和小肠手术的SSI事件。如果成功， 该试验将为675,000名非脑镜的人提供一项简单的预防措施 每年涉及大小肠道的手术。