HERCULES: Exposome Research Center

HERCULES：暴露研究中心

• 批准号: 10668224
• 负责人: Stefanie Ebelt
• 金额: $ 40.87万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-21 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668224
• 关键词: Address; Animals; Area; Basic Science; Bioinformatics; Biological; Biological Markers; Biological Models; Biology; Cell Culture Techniques; Chemicals; Chemistry; Clinical; Clinical Management; Clinical Research; Clinical Sciences; Collaborations; Communities; Core Facility; Data; Data Science Core; Development; Discipline; Disease; Environment; Environmental Exposure; Environmental Health; Evaluation; Evaluation Research; Exposure to; Fostering; Foundations; Funding; Health; Health Sciences; Human; International; Intervention; Knowledge; Laboratories; Leadership; Life; Liquid substance; Mass Spectrum Analysis; Measures; Methods; Mission; National Institute of Environmental Health Sciences; Outcome; Phenotype; Pilot Projects; Population; Population Research; Population Study; Public Health; Research; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Role; Science; Scientific Inquiry; Scientist; Services; Structure; Technology; Testing; Time; Translational Research; Translations; Vision; Work; analytical method; chemical association; clinical biomarkers; community engagement; complex biological systems; design; environmental agent; environmental chemical; epidemiology study; human tissue; innovation; interest; investigator training; laboratory facility; meetings; member; metabolome; metabolomics; novel; outreach; population based; programs; research facility; response; success; tissue culture; tool; training opportunity

HERCULES: INTEGRATED HEALTH SCIENCES FACILITY CORE – SUMMARY Partnering with HERCULES Cores that define and apply (Community Engagement Core, CEC), enable and interpret (Environmental Health Data Sciences Core, EHDSC), innovate (Pilot Project Program, PPP), and coordinate and evaluate (Administrative Core), the Integrated Health Sciences Facility Core (IHSFC) will operationalize translational research on the exposome. Specifically, the IHSFC will: deliver targeted analytical support to quantify exposures to known hazardous environmental agents, environmentally-important clinical biomarkers, and suspect chemicals (Aim 1); provide untargeted analytical support for global study of known and unidentified endogenous and exogenous chemicals associated with environmental exposures or adverse health outcomes (Aim 2); offer comprehensive clinical and population research services to Center-based scientists (Aim 3); and catalyze applied translational research on the exposome in humans and in communities of interest (Aim 4). Drawing on the strong foundation developed during the first two rounds of Center funding, the IHSFC will expand in several key areas: 1) with the very successful programs in targeted and untargeted analytical support, we will focus in Aims 1 and 2 on new innovations within our laboratory and analytical methods; 2) with research support structure that bridges clinical and population-based research in Aim 3, we will emphasize outreach and broad utilization of the IHSFC; and 3) building on tested exposomics tools and technology, we will emphasize and prioritize a broader vision of translational research on the exposome in Aim 4. In doing so, the IHSFC will promote discovery in established and emerging environmental health concerns and will foster development, implementation, and assessment of interventions to address these concerns. IHSFC activities will be driven by the HERCULES exposome and translational research frameworks that incorporate community knowledge and concerns. The IHSFC team has established national and international research leadership in exposure science, chemistry, quantitative biology, metabolomics, and clinical and population studies in broad environmental health areas. Within the Center, the IHFSC will work closely with the CEC to enhance bidirectional understanding of exposome-related concepts, research, and their importance in human health among HERCULES Member and community partners. The IHSFC will continue its key role as a driver of the EHDSC, specifically to deliver data, enhance EHDSC utilization, and facilitate development of exposome-related tools. The IHSFC will support investigators seeking to submit proposals to the PPP and will support PPP-funded novel research projects that facilitate translation and integration of exposome-related research data, tools and concepts. Moreover, the IHSFC will work closely with the Administrative Core in translational research planning, to enhance training opportunities, and to ensure that IHSFC aims are being met and that its services are meeting the needs of Center Members, through tracking and evaluation.

大力神：综合健康科学设施核心 - 摘要 与定义和申请的大力神核心合作（社区参与核心，CEC），启用和 解释（环境健康数据科学核心，EHDSC），创新（试点项目计划，PPP）和 协调和评估（行政核心），综合健康科学设施核心（IHSFC）将 操作有关杂物组的翻译研究。具体而言，IHSFC将：交付的针对性分析 支持量化已知危险环境药物的暴露，至关重要的临床 生物标志物和可疑化学物质（AIM 1）；为已知的全球研究提供非靶向的分析支持 以及与环境暴露或不利相关的未识别的内生和外源化学物质 健康结果（AIM 2）；向基于中心的全面临床和人口研究服务 科学家（目标3）；并催化有关人类和社区的展示体的应用转化研究 感兴趣（目标4）。利用在前两轮中心资金中发展的强大基础， IHSFC将在几个关键领域扩展：1）具有针对性和无目标的非常成功的程序 分析支持，我们将专注于目标1和2 方法; 2）通过桥接AIM 3的临床和人群研究的研究支持结构，我们 将强调IHSFC的外展和广泛利用； 3）建立经过测试的外汇工具和 技术，我们将强调并优先考虑有关AIM的展览组的更广泛的转化研究愿景 4。这样做，IHSFC将促进既定和新兴环境健康问题的发现 并将促进开发，实施和评估干预措施以解决这些问题。 IHSFC的活动将由大力神的展览组和翻译的研究框架驱动 结合社区知识和关注。 IHSFC团队已经建立了国家和国际 曝光科学，化学，定量生物学，代谢组学和临床方面的研究领导 广泛环境卫生领域的人口研究。在中心内，IHFSC将与 CEC增强对杂物体相关概念的双向理解，研究及其在 大力神成员和社区伙伴之间的人类健康。 IHSFC将继续其作为一个关键作用 EHDSC的驱动程序，专门用于传递数据，增强EHDSC利用并促进 与外界相关的工具。 IHSFC将支持寻求向PPP提交建议的调查人员 支持由PPP资助的新型研究项目，促进与外博相关的翻译和整合 研究数据，工具和概念。此外，IHSFC将与行政核心紧密合作 翻译研究计划，以增强培训机会，并确保IHSFC的目标 MET，通过跟踪和评估，其服务正在满足中心成员的需求。