HERCULES: Exposome Research Center

HERCULES：暴露研究中心

• 批准号: 10668222
• 负责人: Carmen Joseph Marsit
• 金额: $ 156.61万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-21 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668222
• 关键词: Acceleration; Address; Affect; Area; Award; Biological; Charge; Collaborations; Communicable Diseases; Communication; Communities; Core Facility; Data Science; Data Science Core; Dimensions; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Evaluation; Exposure to; Extramural Activities; Fostering; Funding; Goals; Growth; Health; Health Priorities; Health Sciences; Home; Human; Individual; Infrastructure; Knowledge; Laboratories; Laboratory Research; Leadership; Learning; Longevity; Mentorship; Mind; Mission; National Institute of Environmental Health Sciences; Nongovernmental Organizations; Output; Personal Satisfaction; Pilot Projects; Policies; Prevalence; Program Development; Public Health; Public Health Practice; Research; Research Personnel; Research Support; Resolution; Resource Development; Resources; Risk; Services; Shapes; Societal Factors; Societies; Strategic Planning; Technology; Time; Translational Research; Translations; United States; Universities; Vision; Work; career; career development; climate crisis; community engaged research; community engagement; data ecosystem; data science resource; environmental health disparity; experience; holistic approach; improved; innovation; laboratory facility; member; metabolomics; metropolitan; programs; recruit; response; skills; tool; translational engagement; translational goal; translational pipeline

PROJECT SUMMARY – HERCULES: EXPOSOME RESEARCH CENTER The Emory Human Exposome Research Center Understanding Lifetime ExposureS (HERCULES) Environmental Health Core Center has an overarching vision to serve as an intellectual hub in the advancement and translation of exposome research to improve human health. Our vision is shaped by a charge to enhance and extend environmental health research, foster innovation and collaboration, engage with communities and stakeholders, and support research translation to accelerate impact. HERCULES employs the framework of the exposome, defined as the totality of exposures, biological responses and societal factors experienced across a lifespan, which impact the environment experienced by an individual. HERCULES Members comprise 71 researchers from 24 departments at Emory University and the Georgia Institute of Technology, connected by a shared mission of learning how the exposome affects health and community well- being and using that knowledge to improve human health. The overarching goals of the Center are to a) innovate in the tools, application, and data science of exposome research, b) promote and grow translational environmental health research at Emory and Georgia Tech, and c) strengthen and expand partnerships with metro Atlanta area communities to enhance their ability to assess their exposome and respond to their environmental health priorities. To achieve these goals, HERCULES supports an Integrated Health Sciences Facilities Core, which operationalizes the exposome concept within a targeted analysis facility, an untargeted high resolution metabolomics facility, and translational research unit, as well as an Environmental Health Data Sciences Core to enable and interpret multidimensional exposomic output, providing an ecosystem of data sciences services. The Community Engagement Core serves to define and apply exposomics through bi-directional interactions with community groups and stakeholders and leads a program of community engagement and support. Our highly successful Pilot Project Program innovates exposome research, with priorities on early career investigators, translational, and community-engaged research through both larger traditional pilots and smaller, time-sensitive awards. The Center’s Administrative Core coordinates activities and communication and uses evaluation to ensure that the Center’s goals are achieved. A career development program also will support targeted early career investigators recruited to Emory and the Center and will provide support for both early career and established investigators to develop new skills or research directions. In its vision, aims, and diverse community of members and stakeholders, HERCULES serves as the home to environmental health research at Emory University, Georgia Tech, and the metro Atlanta area, providing infrastructure, scientific leadership, and collaborative resources for our members to develop and implement innovative exposome research and improve human health.

项目摘要 - 赫拉克勒斯：外博研究中心 埃默里人类杂物组研究中心了解终生暴露（赫拉克勒斯） 环境健康核心中心具有总体愿景，可以作为智力中心 展示体研究的进步和翻译以改善人类健康。我们的视野是由 收费以增强和扩展环境健康研究，促进创新和协作，与 社区和利益相关者，并支持研究翻译以加速影响。大力神雇用 暴露体的框架定义为曝光，生物学反应和社会因素的总体 在寿命中经历的，这会影响一个人所经历的环境。大力神 成员组成了来自埃默里大学24个系和佐治亚研究所的71名研究人员 通过学习曝光如何影响健康和社区良好的共同使命，技术联系 存在并利用这些知识来改善人类健康。中心的总体目标是A） 在展览组研究的工具，应用和数据科学中进行创新，b）促进和发展翻译 Emory和Georgia Tech的环境健康研究，以及C）加强和扩展与 亚特兰大大都会地区社区，以增强他们评估其展示体的能力并回应他们的 环境健康重点。为了实现这些目标，大力神支持综合的健康科学 设施核心，该核心在目标分析设施中运行裸露的概念，这是一个不受限制的 高分辨率代谢组学设施和翻译研究单元以及环境健康 数据科学的核心启用和解释多维外汇输出，提供了一个生态系统 数据科学服务。社区参与核心核心通过 与社区团体和利益相关者的双向互动，并领导社区计划 参与和支持。我们非常成功的飞行员项目计划创新的宣传体研究，并 早期职业调查人员，翻译和社区参与研究的优先事项，都通过两个 传统飞行员和较小的时间敏感奖项。该中心的行政核心协调活动 沟通并使用评估以确保实现中心的目标。职业发展 计划还将支持招募到埃默里和中心的有针对性的早期职业调查员，并将提供 支持早期职业和既定研究人员，以开发新技能或研究方向。在它的 Hercules的愿景，目标以及由成员和利益相关者组成的潜水社区，是 埃默里大学，佐治亚理工大学和亚特兰大大都会地区的环境卫生研究，提供 我们的成员开发和实施的基础架构，科学领导和协作资源 创新的外汇研究并改善人类健康。