Enriching the Rhode Island Child Health Study

丰富罗德岛州儿童健康研究

基本信息

批准号：
10200810
负责人：
Carmen Joseph Marsit
金额：
$ 33.81万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2022-12-22
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10200810
关键词：
Adolescence Age Behavioral Biological Biological Markers Birth Chemicals Child Child Health Childhood Cohort Studies Collaborations Collection Communities Data Data Analyses Data Collection Data Set Development Disease Disease Outcome Enrollment Environment Environmental Epidemiology Environmental Exposure Environmental Health Environmental Impact Epidemiologist Epidemiology Epigenetic Process Exposure to Faculty Follow-Up Studies Fostering Funding Future Goals Grant Growth Health Hospitals Incentives Infant Infrastructure Intervention Investigation Investments Link Longterm Follow-up Maintenance Massachusetts Measures Mediating Mediator of activation protein Medical Records Medical center Molecular Molecular Biology Monoclonal Antibody R24 Mothers National Institute of Environmental Health Sciences Newborn Infant Online Systems Outcome Participant Pathogenesis Pathway interactions Peer Review Placenta Placental Biology Population Predisposition Psychologist Public Policy Publications Recontacts Research Research Infrastructure Research Personnel Research Project Grants Resource Sharing Resources Rhode Island Risk Assessment Role Sampling Scientist Seminal Social Behavior Source Students System Training United States National Institutes of Health Variant Work cohort community building critical period data resource data sharing data sharing networks disorder risk early adolescence early childhood epigenetic regulation epigenetic variation exposed human population follow-up genomic data health goals improved infancy infrastructure development innovation method development middle childhood neurobehavioral next generation novel offspring postnatal prenatal prenatal environmental exposure prospective research and development research study social success web site

项目摘要

PROJECT SUMMARY/ABSTRACT The proposed project is an R24 infrastructure support grant responsive to RFA-ES-16-004, “Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts.” We propose to maintain and enrich resource infrastructure for the Rhode Island Children's Health Study (RICHS), a cohort developed to examine the impact of the environment on newborn and early childhood health outcomes with a novel focus on the mechanistic role of placenta molecular function. RICHS is a highly productive cohort resource—data collection and analyses to date have resulted in over 40 peer-reviewed publications, and 3 research project grants since 2008 (R01MH094609, R01ES022223, R01ES025145); RICHS has also served as a resource for the training and independent research development of 21 pre- and postdoctoral students and junior faculty. Data and results from the cohort have contributed to the understanding of the fundamental molecular biology of the placenta, the impact of environmental exposures on placental epigenetic regulation, links between placental epigenetic variation in newborn growth and neurobehavioral outcomes, as well as novel methods development. The RICHS cohort is comprised of 840 mother-offspring pairs from the Rhode Island and Southeastern Massachusetts region enrolled from a single, population-representative medical center. RICHS offspring were studied in infancy, but maintenance funds are needed for longitudinal follow-up. The proposed infrastructure support would facilitate future prospective, longitudinal assessments within this extensively characterized prenatal cohort, including novel child health and disease outcomes, postnatal environmental exposures, as well as novel and repeated measures of molecular mediators and biomarkers during the critical window of susceptibility of childhood and early adolescence. The proposed infrastructure support will also allow extensive resource-sharing of RICHS data with the larger scientific community. The specific goals of this R24 are to: (1) recontact and reconsent all RICHS mother-child pairs to allow for continued and expanded follow-up, (2) develop an innovative website for cohort maintenance and cohort community building, (3) develop a web-based data collection system for ongoing data collection using REDCap, (4) provide ongoing incentives for maintaining participant investment in RICHS, (5) collect medical record, neurodevelopmental measures and biospecimens for future research studies, and (6) develop systems for broad sharing of cohort data with the larger research community. Our study fits with NIEHS goals to identify fundamental shared mechanisms, to consider the totality of human exposures, biological pathways, and disease pathogenesis, to foster collaboration, and to inspire new cadre of environmental health scientists. Ultimately, the proposed RICHS infrastructure support will maximize NIEHS investment in a unique cohort resource to allow for further seminal work from our highly productive research group and broad sharing of data and resources with the scientific community.

项目摘要/摘要拟议的项目是R24基础设施支持赠款，对RFA-ES-16-004的响应，“维护和富集现有环境流行病学同伙的资源基础架构。维护和丰富罗德岛儿童健康研究（Richs）的资源基础设施，开发旨在检查环境对新生儿和幼儿健康成果的影响新颖的关注胎盘分子功能的机械作用。 Richs是一个高产的队列资源 - 迄今为止的DATA收集和分析已导致40多个同行评审出版物，3个自2008年以来的研究项目赠款（R01MH094609，R01ES022223，R01ES025145）;有钱人也有作为培训和独立研究开发的资源学生和初级教师。队列的数据和结果有助于理解 plapeta的基本分子生物学，环境暴露对花生表观遗传的影响调节，新生儿生长与神经行为结局的斑点表观遗传变异之间的联系，以及新方法的发展。 Richs Gohort由The The 840 Mother-Owdspring对罗德岛和马萨诸塞州东南部地区是一个单一的人口代表性的医疗中心。富裕后代是婴儿期的工作坊，但纵向需要维护资金后续。拟议的基础设施支持将促进未来的前瞻性，纵向评估在这种广泛特征的产前队列中，包括新的儿童健康和疾病结果，产后环境暴露，以及分子介体的新颖和重复测量在童年和青少年早期易感性的关键窗口中的生物标志物。提议基础设施支持还将允许大量资源分享富人数据，并具有更大的科学社区。该R24的具体目标是：（1）重新连接并重新连接所有富裕的母子对允许继续和扩大后续行动，（2）开发一个创新的网站，以进行队列维护和队列社区大楼，（3）开发基于网络的数据收集系统，用于使用 REDCAP，（4）提供了维持参与者投资富裕的持续激励措施，（5）收集医疗记录，神经发育测量和未来研究研究的生物测量，以及（6）开发系统与更大的研究社区共享队列数据。我们的研究适合NIEHS目标基本共同的机制，以考虑人类的全部暴露，生物学途径和疾病发病机理，促进合作，并激发新的环境健康科学家干部。最终，拟议的富裕基础设施支持将最大程度地提高Niehs投资队列资源，允许我们高产研究小组的进一步半效果与科学界共享数据和资源。