Physician Scientist Training in Cancer Research

癌症研究医师科学家培训

• 批准号: 10668481
• 负责人: Jennifer R Brown
• 金额: $ 53.9万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668481
• 关键词: Physicians; Scientist; Training; anticancer research

Summary With this competitive renewal application, we are seeking five years of support for a Training Program with the new Title of “Physician Scientist Training in Cancer Research” that has been continually funded since 1975. Since that time, more than 600 physicians and physician-scientists who were part of fellowship training programs in medical oncology received, through this funding mechanism, the essential support and protected time that they required to launch an academic career. Of the 117 trainees who have been supported by this T32 Award during the past 15 years, 13 continue as post-doctoral fellows in training. Of the remaining 104, 10 have left academia to pursue leadership positions in industry focused on cancer medicine, 6 are clinicians at major medical centers, 2 hold positions at the National Cancer Institute, and the remaining 86 are in academic positions including 2 Professors, 22 Associate Professors, 39 Assistant Professors, and 23 Instructors. Excluding fellows still in training, 90 former trainees of the remaining 104 have received external funding for their research including 37 that have been awarded an individual NIH K-type award. With the present application, we seek to continue this tradition of training the leaders in academic oncology. The future of cancer research will continue to depend on the continued training of highly-talented and creative physician-scientists who possess an understanding of the clinical aspects of neoplastic disease, are able to apply these concepts to appropriate laboratory studies within the many areas of tumor biology and emerge as academic leaders with sufficient skills to direct research programs, patient care, and educational efforts. The development of such individuals can only be accomplished within an environment where physicians and scientists work in physically adjacent areas, exchanging ideas and collaborating on a wide array of endeavors. The program will build on a foundation of excellence in Medical Oncology established during clinical training in the Dana-Farber/Massachusetts General Brigham Medical Oncology Fellowship Program. All of these candidates have already received an MD or MD/PhD degree, completed 2 or 3 years of Internal Medicine residency, and at least one year of clinical training in Medical Oncology. The training grant program will select the most highly qualified candidates from this pool who wish to pursue laboratory research or clinical investigation at the Dana-Farber Cancer Institute or nearby surrounding institutions. The program will provide outstanding mentored laboratory and clinical investigation research experiences from senior and experienced junior faculty and support for the recruitment and mentorship of under-represented minority fellows. It is expected that at the conclusion of their training, those individuals supported by this training program will have the ability to design, initiate, and complete individual clinical or laboratory research projects, will be able to function independently or with minimal supervision, and will be positioned to soon establish themselves as independent research investigators.

概括 通过此竞争性更新申请，我们正在寻求与 从那以后，新的“癌症研究医师科学家培训”的名称已被不断资助 1975年。从那时起，有600多名医生和医师科学家，他们是研究金培训的一部分 通过这种资金机制收到的医学肿瘤学计划，基本的支持和受保护 他们需要启动学术生涯的时间。在这117名受训人员中 在过去的15年中，T32颁奖典礼在培训中继续担任博士后研究员。剩下的104、10 已经离开学术界继续从事专注于癌症医学的行业领导职务，6位是临床医生 主要的医疗中心，国家癌症研究所的2个职位，其余86位在学术中 职位包括2位教授，22名副教授，39名助理教授和23位讲师。 不包括仍在培训中的研究员，其余104名以前的培训已获得外部资金 他们的研究在内，包括37项获得了个人NIH K型奖。与现在 应用程序，我们寻求继续培训学术肿瘤学领导者的传统。 癌症研究的未来将继续取决于对高度富裕和的培训 对肿瘤疾病的临床方面有了解的创造性的身体科学家是 可以将这些概念应用于肿瘤生物学许多领域的适当实验室研究和 成为具有足够技能的学术领导者，可以指导研究计划，患者护理和教育 努力。此类人的发展只能在一个环境中实现 医师和科学家在物理邻近的领域，交换思想和合作 一系列努力。该计划将建立在建立的医学肿瘤学卓越基础的基础上 在Dana-Farber/Massachusets的临床培训期间 程序。所有这些候选人已经获得了MD或MD/PHD学位，完成了2或3年 内科住所，以及至少一年的医学肿瘤学临床培训。 培训赠款计划将从该游泳池中选择最合格的候选人 在Dana-Farber癌症研究所或附近进行实验室研究或临床研究 机构。该计划将提供出色的心态实验室和临床调查研究 高级和经验丰富的初级教师的经验以及对招募和心态的支持 代表性不足的少数民族。预计在他们的培训结束时，这些人 在此培训计划的支持下，将有能力设计，启动和完成个人临床或 实验室研究项目将能够独立或在最低限度的监督下运作，并且将是 定位以很快成为独立研究调查员。

项目成果

Cost-effectiveness of immune checkpoint inhibitors for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer.

• DOI: 10.1002/cncr.31795
• 发表时间: 2019-01-15
• 期刊: Cancer
• 影响因子: 6.2

An enzyme-linked immunosorbent assay (ELISA) for the detection of monoclonal antibodies to cell surface antigens on viable cells.

酶联免疫吸附测定 (ELISA)，用于检测活细胞上细胞表面抗原的单克隆抗体。

• DOI: 10.1016/0022-1759(82)90206-x
• 发表时间: 1982
• 期刊: Journal of immunological methods
• 影响因子: 2.2
• 作者: Posner,MR;Antoniou,D;Griffin,J;Schlossman,SF;Lazarus,H
• 通讯作者: Lazarus,H

Fatal hepatic necrosis following imatinib mesylate therapy.

• DOI: 10.1182/blood-2003-07-2323
• 发表时间: 2003-11
• 期刊: Blood
• 影响因子: 20.3
• 作者: N. Lin;S. Sarantopoulos;J. Stone;I. Galinsky;R. Stone;D. DeAngelo;R. Soiffer

Circulating Tumor DNA Provides a Sneak Peek into Treatment Responses in Non-Small Cell Lung Cancer.

• DOI: 10.1158/0008-5472.can-19-0231
• 发表时间: 2019-03-15
• 期刊: Cancer research
• 影响因子: 11.2

Inherited Platelet Disorders.

遗传性血小板疾病。

• DOI: 10.1016/j.hoc.2021.07.003
• 发表时间: 2021
• 期刊: Hematology/oncology clinics of North America
• 作者: Tsai,FrederickD;Battinelli,ElisabethM
• 通讯作者: Battinelli,ElisabethM