Molecular Biophysics Training Program
分子生物物理学培训计划
基本信息
- 批准号:10669042
- 负责人:
- 金额:$ 24.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Abstract
New experimental and computational/theoretical biophysical approaches have been developed at a rapid pace
recently, placing the field of Molecular Biophysics in a position to drive future major advances in biomedical
sciences. This proposal describes a Molecular Biophysics Training Program at UT Southwestern that will train a
next generation of biophysicists to master new and standard biophysical approaches, analyze and interpret
complex sets of data, in rigorous and reproducible manners. The Program aims to develop a broad
understanding of biology, to allow our trainees to use molecular biophysical advances to answer the most
important biomedical questions. As research becomes more complex, researchers must communicate effectively,
both within interdisciplinary research teams and to a lay public. Quantitative biophysical researchers will also
need to represent society in general. This proposal aims to develop a diverse group of biophysical trainees with
the breadth of skills to become leaders across the biomedical workforce. We will achieve these goals by providing
high quality research training through a rigorous curriculum that couples principles and methods of physical
sciences and mathematics to studies of cell and molecular biology. We will teach students to become conversant
with the scientific literature and be able to effectively and critically communicate research findings, as
implemented in Works In Progress seminars, Journal Clubs, the Molecular Biophysics Discussion Group or
MBDG seminar series and a yearly research symposium. Enhanced training specific to T32 appointees will
include annual Advisory Meeting and Mini-Symposium, and unique opportunities within the MBDG and research
symposium. Trainees will be drawn from the interdisciplinary Molecular Biophysics Graduate Program, which
has faculty from many different Departments and Centers, allowing the Training Program to draw from the
Graduate Program’s resources. The Training Program is, however, also structured to evolve with trainees’ needs
as they navigate an ever-changing scientific and professional landscape. We request funding for 6 predoctoral
slots each year to pursue the mission and goals of the Training Program. There are currently 26 training grant
eligible students in the labs of 26 participating program faculty, who are well-funded and have research portfolios
cross the spectrum of interdisciplinary, biophysical methods, providing different, complementary approaches to
a variety of important biomedical questions. Collectively, the faculty have trained 58 students in the past 10
years; 93% of their graduates still in science. The training program is unique (minimal overlap with other T32
programs on campus) as participating faculty are united by their use of biophysical methods. The quality and
quantity of students, the participating faculty with strong training records, diverse and well-funded scientific
portfolios, and the uniqueness of the training program’s focus form a rock-solid foundation for this Molecular
Biophysics Training Program proposal.
!
抽象的
新的实验和计算/理论生物物理方法已经快速开发
最近,将分子生物物理学领域置于推动生物医学的未来重大进展的位置
科学。该建议描述了UT西南部的一项分子生物物理学培训计划,该计划将训练
下一代生物物理学家掌握新的和标准的生物物理方法,分析和解释
严格和可重复的举止,复杂的数据集。该计划旨在发展广泛的
了解生物学,让我们的学员使用分子生物物理进步来回答最大
重要的生物医学问题。随着研究变得越来越复杂,研究人员必须进行有效的沟通,
在跨学科研究团队中,都在外行公众中。定量生物物理研究人员也将
一般需要代表社会。该建议旨在与
成为生物医学劳动力领导者的技能的广度。我们将通过提供这些目标来实现这些目标
通过严格的课程培训高质量的研究培训
细胞和分子生物学研究的科学和数学。我们将教学生成为转换器
借助科学文献,能够有效和批判性地传达研究结果,因为
在正在进行的工作中实施,期刊俱乐部,分子生物物理学讨论小组或
MBDG开创性系列和年度研究研讨会。特定于T32任命的增强培训将
包括年度咨询会议和迷你咨询,以及MBDG和研究中的独特机会
座谈会。学员将从跨学科的分子生物物理学研究生课程中得知,该计划
有来自许多不同部门和中心的教师,允许培训计划从
研究生计划的资源。但是,培训计划也是旨在随着培训的需求而发展的
当他们驾驶不断变化的科学和专业景观时。我们要求资助6个
每年要追求培训计划的任务和目标。目前有26个培训补助金
26个参与计划教师的实验室中的合格学生,他们资金充足并拥有研究组合
跨越跨学科的生物物理方法的光谱,提供不同的完整方法
各种重要的生物医学问题。在过去的10个中,总体上已经培训了58名学生
年;他们有93%的毕业生仍在科学领域。培训计划是独一无二的(与其他T32重叠最小
校园中的计划)作为参与教师的使用,通过使用生物物理方法结合在一起。质量和
数量的学生,具有强大培训记录的参与教师,潜水员和资金充足的科学
投资组合,培训计划的焦点的独特性构成了这种分子的岩石基础
生物物理学培训计划建议。
呢
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Atomic insights into ML-SI3 mediated human TRPML1 inhibition.
- DOI:10.1016/j.str.2021.06.003
- 发表时间:2021-11-04
- 期刊:
- 影响因子:0
- 作者:Schmiege P;Fine M;Li X
- 通讯作者:Li X
Expression, Purification, and Structure Determination of Human PTCH1-HH-N Complexes.
人 PTCH1-HH-N 复合物的表达、纯化和结构测定。
- DOI:10.1007/978-1-0716-1701-4_10
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Qi,Xiaofeng;Schmiege,Philip;Esparza,Leticia;Li,Xiaochun
- 通讯作者:Li,Xiaochun
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Yuh Min Chook其他文献
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{{ truncateString('Yuh Min Chook', 18)}}的其他基金
Biochemical and cellular functions of Karyopherins
核传递蛋白的生化和细胞功能
- 批准号:
10626755 - 财政年份:2021
- 资助金额:
$ 24.16万 - 项目类别:
Biochemical and cellular functions of Karyopherins - Revision - 1
核传递蛋白的生化和细胞功能 - 修订版 - 1
- 批准号:
10555037 - 财政年份:2021
- 资助金额:
$ 24.16万 - 项目类别:
Biochemical and cellular functions of Karyopherins
核传递蛋白的生化和细胞功能
- 批准号:
10427212 - 财政年份:2021
- 资助金额:
$ 24.16万 - 项目类别:
Biochemical and cellular functions of Karyopherins
核传递蛋白的生化和细胞功能
- 批准号:
10190554 - 财政年份:2021
- 资助金额:
$ 24.16万 - 项目类别:
Splicing and Nuclear Transport of Influenza Virus mRNA
流感病毒 mRNA 的剪接和核转运
- 批准号:
9278114 - 财政年份:2016
- 资助金额:
$ 24.16万 - 项目类别:
Splicing and Nuclear Transport of Influenza Virus mRNA
流感病毒 mRNA 的剪接和核转运
- 批准号:
9913442 - 财政年份:2016
- 资助金额:
$ 24.16万 - 项目类别:
Structures and mechanisms of nuclear import and export
核进出口的结构和机制
- 批准号:
8795191 - 财政年份:2004
- 资助金额:
$ 24.16万 - 项目类别:
Structures and mechanisms of nuclear import and export
核进出口的结构和机制
- 批准号:
7344817 - 财政年份:2004
- 资助金额:
$ 24.16万 - 项目类别:
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