Whole genome sequencing for outbreak investigations of foodborne pathogens and antimicrobial resistance studies for FDA Vet-LIRN

用于食源性病原体爆发调查的全基因组测序和 FDA Vet-LIRN 的抗菌药物耐药性研究

基本信息

批准号：
10669001
负责人：
Melanie Prarat
金额：
$ 7.5万
依托单位：
OHIO STATE DEPARTMENT OF AGRICULTURE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-05 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10669001
关键词：
Whole genome sequencing outbreak investigations

项目摘要

FDA CVM Vet-LIRN PROGRAM GRANT PROPOSAL FOR FOA # PAR-18-604 “Vet-LIRN Network Capacity-Building Projects” ABSTRACT This grant proposal from the Ohio Department of Agriculture (ODA) is in response to Funding Opportunity Announcement (FOA) # PAR-18-604 from the Food and Drug Administration’s (FDA) Center for Veterinary Medicine (CVM) Office of Research Veterinary Laboratory Investigation and Response Network (Vet-LIRN). The project is titled “Whole genome sequencing for outbreak investigations of foodborne pathogens and antimicrobial resistance studies for FDA Vet-LIRN”. This proposal from ODA’s Animal Disease Diagnostic Laboratory (ADDL) addresses the following key project areas: 1. Increasing the capacity of laboratories conducting pathogen susceptibility testing by funding the updating or purchasing of additional equipment. 2. Procurement of supplies needed for AMR testing efforts or method improvement. 3. Purchase of liquid handling system for handling of samples for Vet-LIRN foodborne pathogen case investigations. 4. Conduct increased testing in response to a new need identified by the VPO. 5. Participation in multi-laboratory blinded tests to validate newly developed Vet-LIRN Network methods. The ADDL is also poised to address new developments in emerging regulatory sciences as well as urgent or novel areas for potential research. Several additional documents including the internal Proficiency Testing (PT) results (appendix of Research Plan), and certificate of AAVLD accreditation (appendix of Research Plan) are provided along with the

FDA CVM Vet-LIRN 计划拨款提案对于 FOA # PAR-18-604 “Vet-LIRN 网络能力建设项目” 抽象的俄亥俄州农业部 (ODA) 的这项拨款提案是为了回应来自食品和药品管理局的资助机会公告 (FOA) # PAR-18-604 管理局 (FDA) 兽医中心 (CVM) 研究办公室兽医实验室调查和响应网络（Vet-LIRN）。标题为“食源性病原体爆发调查的全基因组测序和 FDA Vet-LIRN 的抗菌药物耐药性研究”。 ODA 动物疾病诊断实验室 (ADDL) 的这项提案解决了以下重点项目领域： 1. 提高实验室进行病原菌敏感性检测的能力通过资助更新或购买额外的设备。 2. 采购 AMR 测试工作或方法改进所需的用品。 3. 购买用于处理 Vet-LIRN 食源样品的液体处理系统病原体病例调查。 4. 进行更多测试，以满足公益创投机构确定的新需求。 5. 参与多实验室盲测以验证新开发的Vet-LIRN 网络方法。 ADDL 还准备应对新兴监管科学的新发展以及潜在研究的紧急或新颖领域。包括内部能力验证（PT）结果（研究计划的附录），以及提供 AAVLD 认证证书（研究计划附录）这