Core F -Integrated Support Services Core

核心 F - 综合支持服务核心

• 批准号: 10634568
• 负责人: JOAN E NICHOLS
• 金额: $ 73.42万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-31 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10634568
• 关键词: Address; Aerosols; Animal Model; Animals; Applied Research; Arthropod Vectors; Basic Science; Bioterrorism; Clinical Trials; Communicable Diseases; Containment; Dangerousness; Development; Diagnostic; Diagnostic tests; Disease; Emerging Communicable Diseases; Environment; Faculty; Funding; Goals; Human Resources; Infection; Institution; Investigation; Laboratories; Laboratory Animals; Licensure; Maintenance; Medical; Modeling; Mus; National Institute of Allergy and Infectious Disease; Postdoctoral Fellow; Protocols documentation; Reagent; Research; Research Activity; Research Infrastructure; Research Personnel; Research Support; Resources; Secure; Services; Site; Texas; Therapeutic; Training; Universities; Vaccines; Validation; Visualization; Zoonoses; biodefense; biothreat; disease transmission; global health; imaging capabilities; laboratory experience; medical countermeasure; next generation; nonhuman primate; operation; pathogen; pre-doctoral; product development; programs; public health emergency; research facility; therapeutic development; therapy development; tool; vaccine evaluation; vector

Project Summary/Abstract The goal of this project is to maintain the Galveston National Laboratory (GNL) at the University of Texas Medical Branch as a part of the NIAID Biodefense Facilities Network to provide access to maximum containment research facilities for NIAID funded investigators, academic collaborators from across the nation and around the world, commercial partners and others as appropriate. This high containment research infrastructure and associated facilities is required to safely and securely conduct research that will facilitate the discovery and development of therapeutics, diagnostics and vaccines for dangerous pathogens requiring biocontainment. This unique resource is also a critical resource to educate the next generation of experts in infectious diseases of global health importance. The GNL actively responds to national public health emergencies by providing rapid assistance in diagnostics, sharing of critical reagents, and contributing to the discovery and development of effective medical countermeasures. To achieve this goal, the GNL maintains cores focused on supporting safe and secure operations and maintenance of maximum containment research facilities and to provide unique resources and tools to investigators working in biocontainment to allow them to rapidly, safely and securely address emerging infectious diseases and bioterrorism threats. Unique capabilities include the ability to generate and quantify aerosol challenges of laboratory animals from mice to non-human primates, access to arthropod vector colonies to support zoonotic disease transmission studies, and state-of-the-art imaging capabilities to visualize findings, among many others. Working together, GNL teams conduct basic and applied research that can transition original discoveries from concept to final product development, validation and licensure.

项目概要/摘要 该项目的目标是维持加尔维斯顿国家实验室 (GNL) 德克萨斯大学医学分部作为 NIAID 生物防御设施网络的一部分 为 NIAID 资助的人员提供最大程度的遏制研究设施 来自全国和世界各地的研究人员、学术合作者， 商业合作伙伴和其他适当的人。这项高遏制研究 基础设施和相关设施需要安全可靠地进行 将促进治疗学、诊断学的发现和开发的研究 以及需要生物防护的危险病原体疫苗。这种独特的资源 也是教育下一代传染病专家的重要资源 对全球健康具有重要意义的疾病。 GNL积极响应国家公众号召 通过提供快速诊断援助、共享关键信息来应对突发卫生事件 试剂，并为有效医疗的发现和开发做出贡献 对策。为了实现这一目标，GNL 的核心重点是支持 最大程度遏制研究的安全可靠运营和维护 设施，并为在该领域工作的调查人员提供独特的资源和工具 生物防护，使他们能够快速、安全地解决新兴问题 传染病和生物恐怖主义威胁。独特的能力包括能够 生成并量化实验动物（从小鼠到非人类）的气溶胶挑战 灵长类动物，获得节肢动物媒介群体以支持人畜共患病传播 研究和最先进的成像能力来可视化发现等 其他的。 GNL 团队共同开展基础和应用研究， 将原创发现从概念转变为最终产品开发、验证和 许可。