Physical Genomics and Engineering Training Program

物理基因组学与工程培训计划

• 批准号: 10633291
• 负责人: Vadim Backman
• 金额: $ 42.44万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633291
• 关键词: Engineering; Genomics; Training Programs

PROJECT SUMMARY/ABSTRACT The mission of the “Physical Genomics Predoctoral Training Program” (PGTP) is to train the next generation of transdisciplinary scientists that will bridge molecular biology, bioengineering, physics, optics, chemistry, and medicine. Through collaboration of program faculty in the McCormick School of Engineering and Applied Sciences, the Feinberg School of Medicine and the Weinberg College of Arts and Sciences, the PGTP aims to enable trainees to acquire and apply a broad skillset that addresses the physical manipulation of living systems in the pursuit of new strategies for the treatment of disease. Physical genomics is a new field that involves understanding the structure, function, and fundamental principles of chromatin, an intricately folded group of macromolecules including DNA, RNA, and proteins that houses genetic information within cells and determines which genes get suppressed or expressed. With this understanding, researchers can reversibly regulate, control, and even reprogram global patterns of gene expression without altering the genes themselves. This has wide implications in the treatment of diseases such as cancer and Alzheimer’s and other potential applications such as improving crop yields and mitigating the impact of climate change on plants and coral reefs. The PGTP will deploy a range of strategies to help trainees integrate practical, hands-on experience with the knowledge base required to advance research in physical genomics. Through an evidence-based approach to training, trainees will participate in experiential learning and seminars focused on reprogramming chromatin to treat disease and engineer living systems to overcome environmental challenges using breakthrough optical imaging, computational genomics, and molecular biology. The trainees will be mentored by faculty with an outstanding record of productivity and mentorship. Program mentors will provide ongoing review, evaluation, and mentoring of trainees with the goal of creating a resilient, diverse cadre of scientific professionals. The ability to regulate the physical structure of chromatin represents a new frontier in biological discovery and has the potential to be one of the major drivers of 21st-century biotechnology. The PGTP aims to position its trainees as the next generation of interdisciplinary biomedical leaders able to explore this frontier through an exceptional training experience in physical genomics.

项目概要/摘要 “物理基因组学博士前培训计划”（PGTP）的使命是培养下一代 跨学科科学家将分子生物学、生物工程、物理学、光学、化学和 通过麦考密克工程与应用学院的项目教师的合作。 科学、范伯格医学院和温伯格艺术与科学学院，PGTP 旨在 使学员能够获得并应用广泛的技能来解决生命系统的物理操纵问题 寻求治疗疾病的新策略。 物理基因组学是一个涉及理解结构、功能和基本原理的新领域 染色质是一组复杂折叠的大分子，包括 DNA、RNA 和蛋白质，其中包含 细胞内的遗传信息决定了哪些基因被抑制或表达。 了解后，研究人员可以可逆地调控、控制甚至重新编程基因的全局模式 表达而不改变基因本身，这对于治疗诸如此类的疾病具有广泛的意义。 癌症和阿尔茨海默氏症以及其他潜在应用，例如提高作物产量和减轻 气候变化对植物和珊瑚礁的影响。 PGTP 将部署一系列策略，帮助学员将实践经验与实践经验相结合。 通过基于证据的方法推进物理基因组学研究所需的知识库。 培训期间，学员将参加体验式学习和研讨会，重点关注染色质重编程 使用突破性光学治疗疾病和设计生命系统以克服环境挑战 学员将接受具有成像、计算基因组学和分子生物学知识的教师的指导。 出色的生产力和指导记录。项目导师将提供持续的审查、评估和指导。 对学员进行指导，旨在培养一支有弹性、多元化的科学专业人员队伍。 调节染色质物理结构的能力代表了生物发现和研究的新领域 有潜力成为 21 世纪生物技术的主要推动者之一 PGTP 旨在定位其自身。 受训者作为下一代跨学科生物医学领导者，能够通过 物理基因组学方面的卓越培训经验。

项目成果

The impact of underrepresented minority or marginalized identity status on training outcomes of MD-PhD students.

• DOI: 10.1186/s12909-023-04399-7
• 发表时间: 2023-06-08
• 期刊: BMC MEDICAL EDUCATION
• 影响因子: 3.6
• 作者: Acosta, Manuel A. Torres A.;Chandra, Sidhanth;Li, Sophia;Yoon, Esther;Selgrade, Daniel;Quinn, Jeanne;Ardehali, Hossein
• 通讯作者: Ardehali, Hossein