LEveraging A viRtual eNvironment (LEARN) to Enhance Prevention of HIV-related Comorbidities in at-risk Minority MSM

利用虚拟环境 (LEARN) 加强对高危少数 MSM 中 HIV 相关合并症的预防

基本信息

批准号：
10666548
负责人：
Silvia Raquel Ramos
金额：
$ 15.99万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10666548
关键词：
AIDS prevention Achievement Active Learning Address Adult Affect African American American Area Award Awareness Behavior Behavior Therapy Behavioral Blood Cardiovascular Diseases Cardiovascular system Cause of Death Chronic Disease Clinical Clinical Trials Consent Data Decision Making Development Diabetes Mellitus Diagnosis Diet Dietary intake Discrimination Educational workshop Electronics Ethnic Origin Foundations Funding Goals HIV Health Health Personnel Health Promotion Health Technology Hypertension Individual Informatics Intervention Interview K-Series Research Career Programs Knowledge Latino Learning Life Life Style Modification Measures Medical Records Mental Depression Mentors Metabolic Metabolic Diseases Methodology Methods Minority Minority Men Mission National Heart, Lung, and Blood Institute Non-Insulin-Dependent Diabetes Mellitus Outcome Participant Perception Persons Phase Physical activity Population Population Heterogeneity Populations at Risk Prevalence Prevention Process Public Health Quality of life Race Research Research Activity Research Design Research Personnel Risk Scientific Advances and Accomplishments Sex Orientation Social Network Social support Structure Technology Testing Time Tobacco Training Training Activity Translating Underserved Population United States United States National Institutes of Health Waiting Lists acceptability and feasibility behavior change cardiovascular disorder prevention career comorbidity design electronic cigarette use ethnic minority experience feasibility testing feasibility trial health equity high risk improved innovation meetings men who have sex with men preference prevent preventive intervention primary outcome professor programs psychosocial racial minority racism skills standardize measure theories usability virtual environment

项目摘要

LEveraging A viRtual eNvironment (LEARN) to Enhance Prevention of HIV-related Comorbidities in at-risk Minority MSM Project Summary The candidate is an Assistant Professor with expertise in chronic illness and informatics whose overarching career goal is to use health technology interventions to contribute to the achievement of health equity through behavior change and comorbidity prevention in diverse and underserved populations living with Human Immunodeficiency Virus. In order to support this goal and leverage their experiences to date, the Mentored Career Development Award training will focus on three areas: 1) Cardiovascular disease prevention in ethnic/racial MSM, 2) Virtual environment (VE) theory and design, 3) advanced research design methods and innovative analytic approaches. Training will consist of didactic and experiential training, workshops intensives, and attendance at national scientific meetings. The candidate is supported by a distinguished team of mentors who are leaders in their respective fields with successful NIH-funded programs of research in cardiovascular disease and chronic illness prevention, technology-based interventions; and advanced methodological design. The long-term goal of this research is to utilize a VE as a means to increase access to online social supports and increase health promotion skills that can be transferred to the real world and result in the prevention of HIV-related cardiovascular and metabolic conditions. The overall objective of this application is twofold: 1) to receive the training and research experience necessary to become an independent researcher who uses health technology interventions for HIV-related chronic illness prevention, and 2) to address the NIH/NHLBI's call for a diverse early-career scientific workforce (e.g. RFA-HL-19- 025). As part of the mentored research, an exploratory sequential wait-list control feasibility clinical trial will be conducted. Aim 1: Explore perceptions about HIV-related comorbidities (i.e., importance, concern) among minority MSM living with HIV. Aim 2: Test the feasibility, acceptability and preliminary effects of a VE to address prevention of HIV- related CVD comorbidities through behavioral and psychosocial outcomes. Aim 2a: Characterize the social network structure and behaviors using process data collected from the VE-based intervention. In Aim 1, 15 qualitative interviews will explore perceptions of HIV-related comorbidity concerns. Aim 2 will be addressed in an iterative multiphase approach. In phase one I will beta test the VE prior to deployment in the proposed clinical feasibility trial. In phase two, I will use the Learning in Virtual Environments (LIVE©) platform to conduct a wait-list control feasibility clinical trial with 80 adult, minority, MSM living with HIV and at-risk for HIV-related comorbidities. While this type of technology has been applied effectively in diabetes and other chronic disease, the ways in which VEs can be used to facilitate knowledge and health promoting behaviors for prevention of HIV-related comorbidities in MSM has not been studied, making this proposal significant and innovative. It is expected that the Mentored Development Award study will represent an early step in the field for prevention of HIV-related comorbidities in ethnic minority MSM and provide the foundation for a R01-funded clinical trial.

利用虚拟环境 (LEARN) 加强艾滋病毒相关合并症的预防处于危险中的少数 MSM 项目概要该候选人是一位助理教授，具有慢性病和信息学方面的专业知识，其总体职业目标是利用卫生技术干预措施促进实现健康通过行为改变和预防合并症来实现公平为了支持这一目标并利用他们迄今为止的经验，人类免疫缺陷病毒。指导型职业发展奖培训将重点关注三个领域：1）心血管疾病预防民族/种族 MSM，2) 虚拟环境 (VE) 理论和设计，3) 高级研究设计方法培训将包括教学和体验式培训、研讨会。候选人得到了杰出团队的支持。导师都是各自领域的领导者，在 NIH 资助的研究项目中取得了成功心血管疾病和慢性疾病预防、基于技术的干预措施和先进技术；本研究的长期目标是利用 VE 作为增加获取机会的手段。在线社交支持并提高健康促进技能，这些技能可以转移到现实世界并取得成果预防艾滋病毒相关的心血管和代谢疾病的总体目标。申请有双重意义：1）接受成为独立专家所需的培训和研究经验使用卫生技术干预措施预防艾滋病毒相关慢性病的研究人员，以及 2) 满足 NIH/NHLBI 对多元化早期职业科学劳动力的呼吁（例如 RFA-HL-19-025）。在指导研究中，将进行探索性顺序等待名单控制可行性临床试验。 1：探索少数民族 MSM 人群对 HIV 相关合并症（即重要性、关注度）的看法目标 2：测试 VE 预防 HIV 的可行性、可接受性和初步效果。通过行为和心理社会结果来识别相关的 CVD 合并症目标 2a：描述社会特征。使用从基于 VE 的干预中收集的过程数据来确定网络结构和行为。定性访谈将探讨对艾滋病毒相关合并症问题的看法，目标 2 将在其中得到解决。在第一阶段，我将在建议的部署之前对 VE 进行 Beta 测试。在第二阶段，我将使用虚拟环境学习（LIVE©）平台进行临床可行性试验。一项等待名单控制可行性临床试验，受试者为 80 名成年人、少数族裔、男男性行为者、艾滋病毒感染者和艾滋病毒相关风险人群虽然这种技术已有效应用于糖尿病和其他慢性疾病， VE 可用于促进预防疾病的知识和健康促进行为的方式尚未对 MSM 中的 HIV 相关合并症进行研究，因此该提议具有重要意义和创新性。预计指导发展奖研究将代表预防领域的早期一步少数民族 MSM 中与 HIV 相关的合并症，并为 R01 资助的临床试验奠定了基础。