LEveraging A viRtual eNvironment (LEARN) to Enhance Prevention of HIV-related Comorbidities in at-risk Minority MSM

利用虚拟环境 (LEARN) 加强对高危少数 MSM 中 HIV 相关合并症的预防

基本信息

批准号：
10221041
负责人：
Silvia Raquel Ramos
金额：
$ 2.34万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2021-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10221041
关键词：
AIDS prevention Achievement Active Learning Address Adult Affect African American American Area Award Awareness Behavior Behavior Therapy Behavioral Blood Cardiovascular Diseases Cardiovascular system Cause of Death Chronic Disease Clinical Clinical Trials Consent Data Decision Making Development Diabetes Mellitus Diagnosis Diet Dietary intake Discrimination Educational workshop Foundations Funding Goals HIV Health Health Personnel Health Promotion Health Technology Hypertension Individual Informatics Intervention Interview K-Series Research Career Programs Knowledge Latino Learning Life Life Style Modification Measures Medical Records Mental Depression Mentors Metabolic Metabolic Diseases Methodology Methods Minority Mission National Heart, Lung, and Blood Institute Non-Insulin-Dependent Diabetes Mellitus Outcome Participant Perception Persons Phase Physical activity Population Population Heterogeneity Populations at Risk Prevalence Prevention Process Public Health Quality of life Research Research Activity Research Design Research Personnel Risk Risk Management Scientific Advances and Accomplishments Sex Orientation Social Network Social support Structure Technology Testing Time Tobacco use Training Training Activity Translating Underserved Population United States United States National Institutes of Health Waiting Lists acceptability and feasibility base behavior change cardiovascular disorder prevention career comorbidity design electronic cigarette use ethnic minority population experience feasibility testing feasibility trial health equity high risk improved innovation meetings men who have sex with men preference prevent preventive intervention primary outcome professor programs psychosocial racial and ethnic racial minority racism skills standardize measure theories usability virtual environment

项目摘要

LEveraging A viRtual eNvironment (LEARN) to Enhance Prevention of HIV-related Comorbidities in at-risk Minority MSM Project Summary The candidate is an Assistant Professor with expertise in chronic illness and informatics whose overarching career goal is to use health technology interventions to contribute to the achievement of health equity through behavior change and comorbidity prevention in diverse and underserved populations living with Human Immunodeficiency Virus. In order to support this goal and leverage their experiences to date, the Mentored Career Development Award training will focus on three areas: 1) Cardiovascular disease prevention in ethnic/racial MSM, 2) Virtual environment (VE) theory and design, 3) advanced research design methods and innovative analytic approaches. Training will consist of didactic and experiential training, workshops intensives, and attendance at national scientific meetings. The candidate is supported by a distinguished team of mentors who are leaders in their respective fields with successful NIH-funded programs of research in cardiovascular disease and chronic illness prevention, technology-based interventions; and advanced methodological design. The long-term goal of this research is to utilize a VE as a means to increase access to online social supports and increase health promotion skills that can be transferred to the real world and result in the prevention of HIV-related cardiovascular and metabolic conditions. The overall objective of this application is twofold: 1) to receive the training and research experience necessary to become an independent researcher who uses health technology interventions for HIV-related chronic illness prevention, and 2) to address the NIH/NHLBI's call for a diverse early-career scientific workforce (e.g. RFA-HL-19- 025). As part of the mentored research, an exploratory sequential wait-list control feasibility clinical trial will be conducted. Aim 1: Explore perceptions about HIV-related comorbidities (i.e., importance, concern) among minority MSM living with HIV. Aim 2: Test the feasibility, acceptability and preliminary effects of a VE to address prevention of HIV- related CVD comorbidities through behavioral and psychosocial outcomes. Aim 2a: Characterize the social network structure and behaviors using process data collected from the VE-based intervention. In Aim 1, 15 qualitative interviews will explore perceptions of HIV-related comorbidity concerns. Aim 2 will be addressed in an iterative multiphase approach. In phase one I will beta test the VE prior to deployment in the proposed clinical feasibility trial. In phase two, I will use the Learning in Virtual Environments (LIVE©) platform to conduct a wait-list control feasibility clinical trial with 80 adult, minority, MSM living with HIV and at-risk for HIV-related comorbidities. While this type of technology has been applied effectively in diabetes and other chronic disease, the ways in which VEs can be used to facilitate knowledge and health promoting behaviors for prevention of HIV-related comorbidities in MSM has not been studied, making this proposal significant and innovative. It is expected that the Mentored Development Award study will represent an early step in the field for prevention of HIV-related comorbidities in ethnic minority MSM and provide the foundation for a R01-funded clinical trial.

利用虚拟环境（学习）来增强与HIV相关的合并症的预防在高危少数民族中项目摘要候选人是具有慢性疾病和信息专业知识的助理教授总体职业目标是使用卫生技术干预措施为实现健康做出贡献通过行为改变和预防合并症的公平性和服务不足的人群人类免疫缺陷病毒。为了支持这一目标并利用他们迄今为止的经验，指导的职业发展奖培训将重点放在三个领域：1）预防心血管疾病在种族/种族MSM中，2）虚拟环境（VE）理论与设计，3）高级研究设计方法和创新的分析方法。培训将包括教学和经验丰富的培训，研讨会强化和参加国家科学会议。候选人得到杰出团队的支持由NIH资助的研究计划中的领导者的导师心血管疾病和慢性疾病预防，基于技术的干预措施；并先进方法设计。这项研究的长期目标是利用VE作为增加访问权限的一种手段在线社会支持并提高可以转移到现实世界的健康促进技能并结果在预防与HIV相关的心血管和代谢状况方面。总体目标申请是双重的：1）获得成为独立的培训和研究经验使用卫生技术干预措施进行HIV相关的慢性疾病的研究人员，2）谈到NIH/NHLBI呼吁对潜水员的早期科学劳动力（例如RFA-HL-19-025）的呼吁。作为将进行修改的研究，将进行一项探索性等待名单控制可行性临床试验。目的 1：探索少数MSM生活中有关HIV相关合并症的看法（即重要性，关注）与艾滋病毒。目标2：测试VE的可行性，可接受性和初步影响，以解决预防HIV- 通过行为和社会心理结局，相关的CVD合并症。 AIM 2A：表征社会使用基于VE的干预收集的过程数据的网络结构和行为。在AIM 1，15 定性访谈将探讨对HIV相关合并症的看法。 AIM 2将在一种迭代多相方法。在第一阶段，我将在拟议的部署之前测试VE 临床可行性试验。在第二阶段，我将使用虚拟环境中的学习（LIVE©）平台进行操作等待列表的控制可行性可行性临床试验与80名成人，少数族裔，患有HIV的MSM和与HIV相关的处于危险中合并症。尽管这种类型的技术已有效地应用于糖尿病和其他慢性疾病中，但可以使用VES来促进知识和健康促进行为的方式来预防 MSM中与HIV相关的合并症尚未研究，这使该提案具有重要意义和创新性。这是预计指导发展奖研究将代表预防该领域的早期一步 HIV相关的少数民族MSM合并症，为R01资助的临床试验奠定了基础。