Targeting added sugar to improve dietary intake in high-risk adolescents

以添加糖为目标，改善高危青少年的饮食摄入量

• 批准号: 10667328
• 负责人: Gina L. Tripicchio
• 金额: $ 13.89万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667328
• 关键词: 16 year old; Address; Adolescent; Adult; American Heart Association; Automobile Driving; Award; Behavior; Behavior Therapy; Behavior assessment; Behavioral trial; Biological Markers; Blood specimen; Calories; Child; Childhood; Chronic; Chronic Disease; Communities; Complement; Complex; Consumption; Cues; Development; Development Plans; Diet; Dietary Assessment; Dietary Intervention; Dietary intake; Dimensions; Disparity; Doctor of Philosophy; Eating Behavior; Ecological momentary assessment; Education; Environment; Goals; Hair; Health; Healthy Eating; High Prevalence; Home environment; Hunger; Intake; Intervention; Investigation; K-Series Research Career Programs; Life Cycle Stages; Low income; Measures; Mentors; Mentorship; Methodology; Methods; Nature; Nutritional; Nutritional Study; Obesity; Outcome; Outcome Assessment; Parents; Participant; Patient Self-Report; Pattern; Phase; Philadelphia; Population; Population Heterogeneity; Public Health; Randomized; Randomized, Controlled Trials; Recommendation; Reducing diet; Reporting; Research; Resource-limited setting; Resources; Risk; Sampling; Satiation; Schools; Source; Statistical Models; Strategic Planning; Technology; Testing; Text Messaging; Time; Training; Unhealthy Diet; United States National Institutes of Health; Universities; Work; Youth; abdominal fat; acceptability and feasibility; age group; behavior change; cardiometabolism; cardiovascular risk factor; career development; comparison group; design; dietary; digital intervention; disorder risk; ethnic minority; experience; health disparity; high risk; high risk population; high-risk adolescents; improved; indexing; innovation; live text; minority children; novel; nutrition; obesity risk; peer influence; pilot test; primary outcome; programs; racial minority; secondary outcome; stable isotope; statistics; sugar; sweetened beverage; vulnerable adolescent

PROJECT ABSTRACT The overall goal of this K01 proposal is to provide Gina Tripicchio, PhD, MSEd, with the training and mentorship to establish an independent program of research focused on innovative behavioral interventions to improve dietary intake in high-risk adolescents. Added sugar (AS) is a prime target for dietary intervention in adolescents; it contributes excess calories with no nutritional benefits, and adolescents consume more AS than any other age group. High-risk adolescents (e.g., racial/ethnic minorities from low-income communities), experience disproportionately higher rates of obesity and diet-related chronic diseases yet remain understudied. A key limitation in developing efficacious trials for this high-risk group is the dearth of information about key factors associated with AS intake. To address this gap, this project aims to characterize key drivers of AS intake in high-risk adolescents using ecological momentary assessment (EMA). EMA allows for the examination of contextually specific dietary influences in real-time, while reducing recall bias and participant burden. This rich information can be used to guide the development of a tailored, salient behavioral intervention. Additionally, an objective stable isotope biomarker of AS has recently emerged and can be used to address key limitations of self-reported outcomes in dietary interventions. Two studies will be employed to meet the aims of this project. Study 1 (years 1-2), will collect EMA from 40 adolescents and examine the feasibility and acceptability of the δ13C biomarker in the target sample. Study 2 (years 3-5), will implement a pilot RCT to test a contextually tailored, technology-enriched intervention in a sample of 70 adolescents, 12-16 years of age, from a low-income community in north Philadelphia. A 3-month behavioral intervention, including group-based sessions, interactive text messaging and parent support, will aim to reduce AS intake compared to an educational comparison group. Changes in AS, as measured by the δ13C biomarker, will be assessed as the primary outcome and total changes in diet quality will be examined as a secondary outcome. A rigorous training plan will complement the proposed research, facilitated by mentors who are experts in nutrition, eating behavior, digital interventions, statistics, and behavioral trials in pediatric populations. Specific training objectives include: 1) ecological momentary assessment, 2) multi-level statistical modeling, 3) assessment of objective nutritional biomarkers and 4) designing and implementing behavioral interventions to address disparities. Temple University's Center for Obesity Research and Education is an ideal setting for this work as it provides extensive research resources and access to a population of diverse, high-risk youth. This K01 will provide novel information about AS intake in high-risk adolescents and test a targeted, tailored intervention to reduce consumption. Findings will support the application of a fully powered R01 trial. This award holds significant potential for public health impact and will enable Dr. Tripicchio to establish a rigorous program of research to improve dietary intake and reduce diet-related chronic disease risk in vulnerable adolescents.

项目摘要 该K01提案的总体目标是向Gina Tripicchio，PhD，MSED提供培训和培训 建立独立研究计划的遗产，重点是创新的行为干预措施 改善高风险青少年的饮食摄入量。添加的糖（AS）是饮食干预的主要目标 青少年；它贡献超过卡路里没有营养益处，青少年的消费量超过 任何其他年龄段。高风险的青少年（例如，来自低收入社区的种族/少数民族）， 肥胖和与饮食有关的慢性疾病的比例不成比例地更高 研究了。为该高风险群体开发有效试验的关键限制是信息的死亡 关于与摄入有关的关键因素。为了解决这一差距，该项目旨在表征关键驱动因素 使用生态瞬时评估（EMA）在高风险青少年中的AS摄入量。 EMA允许 检查上下文特定特定的饮食影响，同时减少召回偏见和参与 负担。这些丰富的信息可用于指导量身定制的显着行为的发展 干涉。此外，最近出现的客观稳定的同位素生物标志物，可以使用 解决饮食干预措施中自我报告的结果的关键局限性。两项研究将被聘为 满足该项目的目标。研究1（1 - 2年）将从40名青少年收集EMA，并检查 目标样品中Δ13C生物标志物的可行性和可接受性。研究2（3-5年）将实施 试点RCT在70名青少年样本中测试上下文量身定制的，富含技术的干预措施，12-16 年龄，来自北费城的低收入社区。三个月的行为干预，包括 基于小组的会议，交互式文本消息传递和父母支持，旨在减少与摄入量相比的摄入量 到一个教育比较小组。通过Δ13C生物标志物测量的AS的变化将被评估为 饮食质量的主要结果和总变化将被视为次要结果。严格 培训计划将完成由营养专家，饮食专家准备的拟议研究 小儿种群中的行为，数字干预，统计和行为试验。具体的培训 目标包括：1）生态瞬时评估，2）多级统计建模，3）评估 客观的营养生物标志物和4）设计和实施行为干预以解决 差异。坦普尔大学肥胖研究与教育中心是这项工作的理想环境 它提供了广泛的研究资源，并获得了潜水员，高风险青年的访问。这个K01会 提供有关高风险青少年摄入量的新颖信息，并测试针对性的，量身定制的干预措施 减少消耗。调查结果将支持全功率R01试验的应用。这个奖项成立 公共卫生影响的巨大潜力，并将使Tripicchio博士建立严格的计划 易受伤害的青少年的研究以改善饮食摄入量并减少与饮食相关的慢性疾病风险。

项目成果

Association of weight status with the types of foods consumed at snacking occasions among US adolescents.

• DOI: 10.1002/oby.23571
• 发表时间: 2022-12
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Croce, Christina M.;Fisher, Jennifer Orlet;Coffman, Donna L.;Bailey, Regan L.;Davey, Adam;Tripicchio, Gina L.
• 通讯作者: Tripicchio, Gina L.

Age-related differences in eating location, food source location, and timing of snack intake among U.S. children 1-19 years.

• DOI: 10.1186/s12966-023-01489-z
• 发表时间: 2023-07-26
• 期刊: INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
• 影响因子: 8.7
• 作者: Tripicchio, Gina L. L.;Croce, Christina M. M.;Coffman, Donna L. L.;Pettinato, Cameron;Fisher, Jennifer O. O.
• 通讯作者: Fisher, Jennifer O. O.

Snack frequency, size, and energy density are associated with diet quality among US adolescents.

• DOI: 10.1017/s1368980023001635
• 发表时间: 2023-11
• 期刊: PUBLIC HEALTH NUTRITION
• 影响因子: 3.2
• 作者: Tripicchio, Gina L.;Bailey, Regan L.;Davey, Adam;Croce, Christina M.;Fisher, Jennifer Orlet
• 通讯作者: Fisher, Jennifer Orlet