Sex and Sex Hormone Factors Influencing Acute Alcohol Effects on Sleep Physiology

影响酒精对睡眠生理的急性影响的性和性激素因素

• 批准号: 10667102
• 负责人: Jessica J Weafer
• 金额: $ 50.65万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667102
• 关键词: 21 year old; Acute; Adult; Age; Alcohol consumption; Alcohols; Area; Biosensor; Blood specimen; Cognition; Data; Dose; Estradiol; Future; General Population; Goals; Gonadal Steroid Hormones; Heavy Drinking; Home; Hormonal; Hormones; Hour; Impairment; Individual; Infusion procedures; Intervention; Intravenous; Laboratories; Longevity; Luteal Phase; Measures; Mediating; Menstrual cycle; Menstruation; Monitor; Ovarian hormone; Ovulation; Participant; Patient Self-Report; Pattern; Personal Satisfaction; Pharmaceutical Preparations; Phase; Placebos; Polysomnography; Prevention; Progesterone; REM Sleep; Reporting; Research; Research Personnel; Risk; Saline; Sex Differences; Sleep; Sleep disturbances; Sleeplessness; Stress; Wakefulness; Woman; Women' s Health; Wrist; actigraphy; age effect; alcohol consequences; alcohol effect; alcohol monitoring; alcohol use disorder; behavioral pharmacology; breath alcohol measurement; design; diaries; drinking; experience; innovation; male; men; negative affect; older women; poor sleep; proliferative phase Menstrual cycle; rapid eye movement; reproductive; sedative; sensor; sex; sex cycle; sleep behavior; sleep physiology; sleep quality; sobriety

Rates of heavy drinking and Alcohol Use Disorder (AUD) are increasing in women at an alarming pace. Such drastic increases in drinking will have a significant negative impact on women’s health. Unfortunately, until recently heavy drinking has been considered a male-oriented problem, and consequently research on alcohol- related harms in women has been minimal. One specific aspect of women’s health that may be negatively affected by alcohol is sleep. Numerous studies in men show that although alcohol has an initial sedative effect, it leads to frequent awakenings and impaired rapid eye movement sleep in the second half of the night. Preliminary evidence suggests that women experience similar impairment, and that they may be even more sensitive to alcohol-disrupted sleep than men. Further, in the general population, women are at greater risk for insomnia and sleep disturbances than men, in part because women’s sleep is sensitive to fluctuations in ovarian hormones. Hormonal influences on sleep are especially pronounced in older women of late reproductive age. However, the influence of sex and sex hormones on alcohol-disrupted sleep across the reproductive lifespan in women is unknown. Here, we will determine the influence of sex, menstrual cycle phase, and sex hormones on alcohol-disrupted sleep in adults across the reproductive age range for women. Healthy women and men (age 21-45) will complete two pairs of experimental sessions in which they receive a dose of alcohol (target BrAC = 100mg%, intravenous) or placebo (saline) one hour prior to eight hours of polysomnographically-monitored sleep in the lab. Women will complete one alcohol-placebo session pair during the mid-follicular phase of the menstrual cycle and one pair during the late luteal phase. Men will complete two session pairs at matched intervals. Participants will also complete two 5-day at-home monitoring periods of naturalistic sleep and alcohol consumption patterns during the mid-follicular and late luteal phases. Sleep and alcohol use will be assessed with actigraphy, daily sleep and wake diaries, and alcohol wrist sensors. We hypothesize that women will show greater disruption of sleep following alcohol than men and that alcohol-disrupted sleep, measured in lab with polysomnography and at-home with actigraphy, will be more pronounced in the late luteal phase compared to the mid-follicular phase. We also expect that estradiol will be negatively associated with alcohol-disrupted sleep, whereas progesterone will be positively associated with alcohol-disrupted sleep. This study will provide essential information regarding alcohol effects on sleep across the reproductive age span in women, and critically, how these effects are moderated by sex, menstrual cycle, and fluctuations in sex hormones. Findings will directly inform future interventions aimed at reducing alcohol consumption and the negative impacts of alcohol on sleep in women. Given the wide-ranging impact of sleep on other areas of function, including cognition, stress, and well-being, such interventions will have a substantial positive impact on women’s health.

在令人震惊的空间中，女性的饮酒和饮酒障碍（AUD）的速度正在增加。这样的 饮酒的急剧增加将对妇​​女的健康产生重大负面影响。不幸的是，直到 最近，大量饮酒被认为是一个面向男性的问题，因此研究酒精 - 女性的相关危害很小。妇女健康的一个具体方面可能是负面的 受酒精影响的是睡眠。男性的大量研究表明，尽管酒精具有最初的镇静作用，但 它导致经常唤醒并在晚上的下半场快速眼球运动障碍。 初步证据表明，妇女经历了类似的障碍，她们可能会更加 对饮酒敏感的睡眠敏感。此外，在一般人口中，妇女面临更大的风险 失眠和睡眠障碍比男性，部分原因是女性的睡眠对波动敏感 卵巢激素。最近的老年女性尤其明显对睡眠的影响 生殖年龄。但是，性与性恐怖对遍布酒精饮酒的睡眠的影响 女性的生殖寿命尚不清楚。在这里，我们将确定性别，月经周期的影响 阶段，以及妇女复制年龄范围内的成年人的酒精中间睡眠的性恐怖。 健康的男女（21-45岁）将完成两对实验性会议，在其中他们接受 酒精剂量（靶Brac = 100mg％，静脉注射）或安慰剂（盐水）八个小时前一小时 实验室中的多个人数摄影仪的睡眠。妇女将完成一对酒精饮料会话对 在月经循环的典型阶段，在黄体晚期期间一对。男人会 以匹配的间隔完成两个会话对。参与者还将完成两个为期5天的家庭监控 在黄体和晚期晚期的自然主义睡眠和饮酒模式的时期。 睡眠和饮酒将通过行动摄影，每日睡眠和唤醒日记以及酒精手腕评估 传感器。我们假设妇女在酒后表现出比男性更大的睡眠中断，并且 在实验室中，通过多渗透学术和带有行为摄影的家庭测量的酒精中断的睡眠将更多 与洋囊中期相比，在黄体晚期发音。我们还希望雌二醇会 与饮酒的睡眠负相关，而孕酮将与 饮酒的睡眠。这项研究将提供有关酒精对整个睡眠影响的基本信息 女性的生殖年龄跨度，并且在批判性地通过性别，月经周期来调节这些影响 性激素的波动。调查结果将直接告知旨在减少酒精的未来干预措施 消费和酒精对女性睡眠的负面影响。鉴于睡眠的广泛影响 在其他功能领域，包括认知，压力和福祉，此类干预措施将具有很大的 对妇女健康的积极影响。