Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

从婴儿早期口腔微生物组了解儿童早期龋齿差异背后的生物因素

• 批准号: 10666930
• 负责人: STEVEN R. GILL
• 金额: $ 11.29万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10666930
• 关键词: Affect; Award; Behavior; Biological Factors; Birth; Child; Counseling; Data; Dental caries; Development; Dietary Iron; Dietetics; Eating Behavior; Exposure to; Foundations; Future; Health; Health Disparities Research; Household; Infant; Intake; Life; Low income; Mothers; Nutritionist; Oral; Oral candidiasis; Oral health; Parents; Perinatal; Pica Disease; Pregnancy; Pregnant Women; Prevention; Research; Research Personnel; Risk; Risk Factors; Solid; Underserved Population; Woman; Yeasts; career; cariogenic bacteria; cohort; dysbiosis; early childhood; early-life nutrition; ethnic minority; feeding; food insecurity; gut microbiome; in utero; infancy; microbial composition; microbiome research; minority communities; nutrition; oral microbial community; oral microbiome; oral supplementation; prenatal; racial and ethnic; racial disparity; skills; yeast infection; Affect; Award; Behavior; Biological Factors; Birth; Child; Counseling; Data; Dental caries; Development; Dietary Iron; Dietetics; Eating Behavior; Exposure to; Foundations; Future; Health; Health Disparities Research; Household; Infant; Intake; Life; Low income; Mothers; Nutritionist; Oral; Oral candidiasis; Oral health; Parents; Perinatal; Pica Disease; Pregnancy; Pregnant Women; Prevention; Research; Research Personnel; Risk; Risk Factors; Solid; Underserved Population; Woman; Yeasts; career; cariogenic bacteria; cohort; dysbiosis; early childhood; early-life nutrition; ethnic minority; feeding; food insecurity; gut microbiome; in utero; infancy; microbial composition; microbiome research; minority communities; nutrition; oral microbial community; oral microbiome; oral supplementation; prenatal; racial and ethnic; racial disparity; skills; yeast infection

Project Summary Early childhood caries (ECC) disproportionately affects children from low-income households and ethnic minority communities. Dysbiosis of oral microbiota, including enrichment of cariogenic bacteria and yeast, increase the risk for ECC. Previous research indicated connections between in-utero and early-life nutrition intake and gut microbiome development. Yet, the impact of in-utero and early-life nutrition intake on maternal and children’s oral microbiome remains unclear. As an augmentation to the parent award R01DE031025 Oral Microbiome in Early Infancy (OMEI), we propose this supplement OMEI + Nutrition. The parent OMEI studies the early-life biological factors underlying ECC racial disparity via a valuable underserved birth cohort. In the OMEI+ Nutrition supplement, we expand the factors to include perinatal nutritive (such as dietary iron intake) and nonnutritive behavior (such as pica) to examine their potential relationships with oral microbiomes during pregnancy and early life. Our central hypothesis is that mothers with nonnutritive eating behavior are associated with a distinct oral microbial community, which influences oral microbiome development in early childhood. We propose the following aims in the OMEI + Nutrition study. Aim 1: Assess the effect of nutritive and nonnutritive eating behavior on the oral microbiome of pregnant women. Aim 2: Assess the impact of maternal nutritive and nonnutritive eating behavior on infants' early-life (birth to 6 months) oral Candida colonization and yeast infection. Aim 3 (Exploratory): assess microbial compositions of pica substances. The OMEI + Nutrition will be the first study that examines the relationship between nutritive (such as dietary iron intake) and nonnutritive (such as pica) factors on perinatal oral microbiome among underserved US pregnant women and their children. Data generated will strengthen the understanding of children’s oral microbiome development and their association to ECC. Additional risk factors revealed from this OMEI+ Nutrition would be used as targets for prenatal counselling, ECC early prediction and prevention, specifically suitable for underserved women and children. This OMEI + Nutrition will be conducted by the diversity supplement applicant, Dr. Brenda Abu, a Nutritionist-Researcher, who will add her strong nutrition and dietetics background to the already integrated health disparities research team. Dr. Abu enthusiastically intends to develop her career in the interaction of nutrition and oral health among the underserved population. This OMEI + Nutrition supplement will advance her skills and expertise in oral health and oral microbiome research, which will build a solid foundation for a future R01 application that assesses eating behavior and oral microbiome on maternal and children’s oral and systemic health.

项目摘要 幼儿汽车（ECC）不成比例地影响低收入家庭的儿童 少数民族社区。口服微生物群的营养不良，包括富集致癌细菌和 酵母，增加ECC的风险。先前的研究表明Utero和早期生活之间的联系 营养摄入和肠道微生物组的发展。然而，内罗和早期营养摄入的影响对 孕产妇和儿童的口服微生物组尚不清楚。作为父母奖的增强 R01DE031025婴儿期（OMEI）的口服微生物组，我们提出了这种补充剂OMEI +营养。这 父母Omei研究ECC种族差异的早期生物生物学因素通过有价值的不足 出生队列。在OMEI+营养补充剂中，我们将因素扩展到包括围产期营养的因素（例如 饮食铁的摄入量）和非营养行为（例如PICA），以检查其与口腔的潜在关系 怀孕和早期生命中的微生物组。 我们的核心假设是，非营养饮食行为的母亲与独特的 口腔微生物社区，这会影响儿童早期口腔微生物组的发展。我们建议 OMEI +营养研究的目标。目标1：评估营养和非营养饮食的影响 孕妇口腔微生物组的行为。目标2：评估母体营养和 婴儿的早期生命（出生到6个月）口服念珠菌和酵母的非营养饮食行为 感染。 AIM 3（探索性）：评估PICA物质的微生物组成。 OMEI +营养将是第一个研究营养之间关系的研究 （例如饮食中的铁摄入量）和非营养（例如PICA）的围产期口腔微生物组的因素 在服务不足的美国孕妇及其子女中。产生的数据将加强 了解儿童口服微生物组的发展及其与ECC的关联。其他风险因素 从这种OMEI+营养中揭示的将被用作产前咨询，ECC早期预测和 预防，特别适合服务不足的妇女和儿童。 多样性补充申请人布伦达·阿布（Brenda Abu）博士将进行这种OMEI +营养 营养学家 - 研究者，她将在已经整合的 健康差异研究团队。阿布博士热情地打算在互动中发展自己的职业 服务不足的人群中的营养和口腔健康。这种OMEI +营养补充剂将推进 她在口腔健康和口腔微生物组研究方面的技能和专业知识，这将为 未来的R01应用程序评估饮食行为和对母校和儿童口头的口服微生物组的应用以及 系统健康。