Climate factors, racial/ethnic disparities, and menstrual cycle health

气候因素、种族/民族差异和月经周期健康

基本信息

批准号：
10633874
负责人：
Shruthi Mahalingaiah
金额：
$ 58.2万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10633874
关键词：
15 year old Acceleration Acne Address Adult Affect Age Air Pollutants Air Pollution Biological Biological Factors Birth Black race Boston Censuses Cessation of life Characteristics Childhood Chronic Cities Climate Clinical Code Cohort Studies Collection Counseling DNA Repair Data Data Set Daughter Diabetes Mellitus Diagnostic Disease Disparity Dyslipidemias Electronic Health Record Embryo Endocrine disruption Enrollment Environment Environmental Exposure Environmental Impact Environmental Risk Factor Exposure to Fertilization in Vitro Goals Growth Health Health Promotion Heart Diseases Hirsutism Hispanic Home Hormones Hospitals Humidity Hypertension Hypothalamic structure Impairment Infertility Inflammation Irregular Menstruation Knowledge Length Life Cycle Stages Literature Longevity Mammals Medical center Menarche Menstrual cycle Menstruation Metabolic syndrome Minority Monitor Nurses Nurses&apos Health Study Obesity Outcome Ovarian Diseases Ovary Oxidative Stress Participant Physiological Pituitary Gland Polycystic Ovary Syndrome Population Pregnancy Pregnancy loss Race Recording of previous events Reporting Reproductive Health Risk Risk Reduction School-Age Population Seminal fluid Temperature Testing Time Toxic effect United States Variant Woman androgen excess burden of illness climate-related exposures cohort ethnic disparity ethnic diversity girls high school hormonal signals male offspring ovarian dysfunction premature prenatal prenatal exposure prospective racial disparity reproductive reproductive function reproductive outcome safety net success telomere time-to-pregnancy

项目摘要

PROJECT SUMMARY The menstrual cycle is a marker of physiologic and reproductive health and is tightly controlled by hormone signals between the hypothalamus, pituitary, and ovaries. The menstrual cycle can be disrupted by environmental and biological factors that cause hormone dysregulation and ovarian dysfunction. The most common cause of irregular menses in reproductive-age women is polycystic ovary syndrome (PCOS); hallmark features include ovarian dysfunction and androgen excess. Women with PCOS also have an increased risk of developing diabetes, heart disease, obesity, dyslipidemia across their lifespan. Climate factors, such as temperature, have been shown to affect reproductive function in mammals. Air pollution (AP) exposure has been associated with accelerated time to pregnancy loss, arrested embryonic growth in the culture environment, and reduced success of in vitro fertilization. Life course exposures have differing potential biological mechanisms. Gestational AP exposure has been reported to reduce telomere length at birth. Assessment of AP exposures and MCC are limited by studies of heterogenous populations with limited racial/ethnic diversity, incomplete city-level census tract level monitoring, retrospective collection of cycle history, and lack of MCC and PCOS ascertainment11, 12. We will additionally evaluate life course exposure to climate factors including temperature and humidity to understand their contribution to MCC outcomes and risk for PCOS. We will evaluate cumulative lifetime exposure and life course exposure to AP during the sensitive time windows of (1) gestation, (2) childhood/premenarche, and (3) adulthood to determine whether prenatal or adult exposures confer greatest risk. We will additionally evaluate disparities in AP exposures and MCC outcomes in a SafetyNet hospital population.

项目概要月经周期是生理和生殖健康的标志，受到激素的严格控制下丘脑、垂体和卵巢之间的信号。月经周期可能会被打乱导致激素失调和卵巢功能障碍的环境和生物因素。最育龄妇女月经不规律的常见原因是多囊卵巢综合症（PCOS）；标志特征包括卵巢功能障碍和雄激素过多。患有多囊卵巢综合症的女性也有更高的风险在一生中患糖尿病、心脏病、肥胖症、血脂异常。温度等气候因素已被证明会影响哺乳动物的生殖功能。空气污染（AP）暴露与加速流产、胚胎停滞有关培养环境中的生长，并降低体外受精的成功率。生命历程暴露有不同的潜在生物学机制。据报道，妊娠期接触 AP 会减少端粒出生时的长度。 AP 暴露和 MCC 的评估受到异质人群研究的限制种族/族裔多样性有限、城市人口普查区层面监测不完整、回顾性收集周期历史，以及缺乏 MCC 和 PCOS 确定11, 12。我们将另外评估生命历程接触温度和湿度等气候因素，了解它们对 MCC 的影响 PCOS 的结果和风险。我们将评估敏感时间内AP的累积终生暴露和生命历程暴露 (1) 妊娠期、(2) 儿童期/初潮期和 (3) 成年期的窗口期，以确定是产前还是成年暴露带来最大的风险。我们还将评估 AP 暴露和 MCC 结果的差异 SafetyNet 医院人口。