Characterization of endovascular ablative therapies with computational modeling

通过计算模型表征血管内消融治疗

基本信息

批准号：
10629321
负责人：
David Fuentes
金额：
$ 18.56万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-26 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10629321
关键词：
Ablation Acids Acute Aliquot Area Behavior Biochemistry Biological Blood flow Bolus Infusion Calibration Catheters Cell Death Characteristics Chemicals Chlorides Clinical Computer Models Convection Data Diameter Diffusion Disease Environment Equilibrium Goals Hydrochloric Acid Hydrolysis Hyperthermia Image Image Enhancement Inflammation Intervention Interventional radiology Intuition Investigation Ischemia Left Liver Mathematics Measurement Measures Methods Modality Modeling Monitor Neoplasm Metastasis Outcome Parents Patients Physics Porosity Primary carcinoma of the liver cells Procedures Process Property Protocols documentation Reaction Reagent Recurrence Reflexology Research Risk Route Solvents Techniques Temperature Therapeutic Embolization Thermal Ablation Therapy Thermal Conductivity Thermometry Tissues Translating Transport Process Validation Vascular blood supply Veterinary Pathology Viscosity chemical reaction clinical translation contrast enhanced curative treatments in vivo insight liver ablation liver function liver preservation mathematical model minimally invasive model development neoplastic cell novel novel strategies patient population porcine model preclinical study predictive modeling pressure prospective quantitative imaging risk minimization simulation tumor vascular bed virtual experiments

项目摘要

Curative therapies are not available to greater than 80% of the patient population with hepatocellular carcinoma (HCC). There is a well-recognized need for novel methods that can intricately balance (1) treatment of the disease extent with (2) preservation of liver function and minimizing risk of recurrence and metastasis. Thermoemboliza- tion provides a novel conceptual platform for minimally invasive interventions in which an acid chloride reagent is delivered through an endovascular route via transarterial catheter. The reagent is dissolved in an inert oily solvent and sandwiched between two aliquots of the inert solvent at the leading and trailing edges. Hydrolysis of the acid chloride within the target tissue simultaneously releases the parent acid and an equivalent of hy- drochloric acid. The localized release of acid combined with disruption of the blood supply as well as the heat energy from the exothermic reaction synergistically causes tumor cell death. Current challenges in translating this exciting therapy to patients are a lack of characterization of the mechanisms for a controlled delivery. Project efforts focus on integrating imaging measurements with mathematical model developments to provide key insight in developing this novel thermoembolization treatment approach. The use of high-ﬁdelity predictive models will characterize fundamental mass, thermal, and chemical transport processes needed for control of an effective thermoembolization delivery without unwanted tissue damage. A highly interdisciplinary team with expertise in imaging physics, mathematical modeling, interventional radiology, veterinary pathology, and biochemistry has been assembled to accomplish this goal.

超过80％的患有肝癌的患者人群的治疗疗法不可用（HCC）。人们对新方法的需求充分认可，可以错综复杂地平衡（1）疾病的治疗（2）保存肝功能并最大程度地减少复发和转移的风险。热栓塞 Tion为微创干预措施提供了一个新颖的概念平台，其中酸氯化物试剂通过透射导管通过血管内路线传递。试剂溶解在惰性油中溶剂并夹在惰性溶剂的两个等分试样之间，处于领先和尾随的边缘。水解目标组织中的氯化物的氯化物简单释放出父酸，相当于hy- 氯酸。酸的局部释放结合了血液供应的破坏以及热量来自放热反应的能量协同导致肿瘤细胞死亡。当前翻译方面的挑战对患者的这种令人兴奋的疗法缺乏对控制分娩的机制的表征。项目努力专注于将成像测量与数学模型开发相结合，以提供关键的见解在开发这种新型的热栓塞治疗方法中。高实现预测模型的使用将表征控制有效的基本质量，热和化学传输过程没有不必要的组织损伤的热栓塞递送。一支具有专业知识的高度跨学科团队成像物理学，数学建模，介入放射学，兽医病理学和生物化学具有被组装以实现这一目标。