Women's oral health in the preconception period: correlates and consequences

女性孕前期的口腔健康：相关性和后果

• 批准号: 10630130
• 负责人: Julia Craig Bond
• 金额: $ 3.71万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10630130
• 关键词: Academy; Address; Adult; Affect; Age; American; Birth; Canada; Centers for Disease Control and Prevention (U.S.); Chronic; Clinic; Clinical; Clinical Research; Clinical Trials; Cluster Analysis; Cohort Studies; Collaborations; Conceptions; Data; Dental Care; Dental Epidemiology; Dental Health Services; Diagnosis; Enrollment; Epidemiologic Methods; Epidemiologist; Factor Analysis; Familiarity; Fellowship; Foundations; Goals; Health; Health Promotion; Health Services; Healthcare; Human; Inflammation; Inflammatory; Internet; Intervention; Link; Literature; Longitudinal Studies; Low Birth Weight Infant; Maternal and Child Health; Measures; Mentorship; Methods; Observation in research; Observational Study; Oral; Oral health; Outcome; Patient Self-Report; Periodontitis; Population; Population Heterogeneity; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnancy loss; Premature Birth; Prevalence; Prospective, cohort study; Randomized, Controlled Trials; Reporting; Reproductive Health; Research; Research Methodology; Research Personnel; Risk; Risk Factors; Sample Size; Selection Bias; Spontaneous abortion; Surveys; Techniques; Time; Tooth Loss; Training; United States; Woman; adverse pregnancy outcome; behavior change; bone; cohort; design; early pregnancy; effectiveness evaluation; epidemiology study; evidence base; improved; insight; modifiable risk; novel; oral tissue; perinatal outcomes; pre-doctoral; pregnant; reproductive; skills; time-to-pregnancy; training opportunity

Project Abstract Periodontitis is the most common chronic health condition in humans and affects an estimated 38% of adult women in the United States. Research has demonstrated a connection between periodontitis and other adverse health outcomes, including reproductive health outcomes of preeclampsia, low birthweight, and preterm birth. However, trials evaluating periodontal treatment in pregnancy have not found a consistent benefit for perinatal outcomes, suggesting that establishment of oral health prior to pregnancy may be required to influence birth outcomes. Thus, research into oral health in the preconception period may provide important insights into potential opportunities for oral health promotion, particularly because attempting conception is often accompanied with behavior changes. Prior research by this investigator evaluating preconception oral health found an association between self-reported preconception periodontitis and a prolonged time-to- pregnancy, but the association between preconception periodontitis and other perinatal outcomes remains uncharacterized. The aim of this research is to address this gap in the literature by providing insights into the causes and consequences of oral health in the preconception period using data from a large, prospective cohort study that follows women from the time they are planning a pregnancy (e.g., preconception). Specifically, Aim 1 will assess predictors of oral health and dental service use in the preconception period. Aim 2 will leverage a Target Trial Framework to emulate a randomized controlled trial to evaluate the impact of preconception receipt of periodontitis treatment among women with periodontitis on time-to-conception. Finally, Aim 3 will examine the association between preconception periodontitis and spontaneous abortion (commonly referred to as miscarriage). Taken together, the proposed project has the potential to provide broad insights into women’s oral health in the preconception period. An accompanying training plan dovetails with the research objectives to provide robust, hands-on training opportunities for the applicant to support her transition to an independent oral health epidemiologist with expertise in observational research methods. The training plan additionally outlines tailored mentorship opportunities from the sponsor and co-sponsors, all of whom are recognized experts in their fields with a track record of successful collaboration with each other and the applicant.

项目摘要 牙周炎是人类最常见的慢性健康状况，估计影响 38% 的成年人 美国女性的研究表明，牙周炎与其他疾病之间存在联系。 不良健康后果，包括先兆子痫、低出生体重和 然而，评估妊娠期牙周治疗的试验并未发现一致的结果。 对围产期结局有益，表明可能需要在怀孕前建立口腔健康 因此，对孕前时期口腔健康的研究可能具有重要意义。 深入了解促进口腔健康的潜在机会，特别是因为尝试受孕是 通常伴随着该研究者先前的研究评估孕前口腔行为的变化。 健康发现自我报告的孕前牙周炎与延长的治疗时间之间存在关联 怀孕，但孕前牙周炎与其他围产期结局之间的关联仍然存在 这项研究的目的是通过提供深入的见解来弥补文献中的这一空白。 使用来自大量前瞻性数据的孕前口腔健康的原因和后果 从女性计划怀孕（例如怀孕前）开始跟踪她们的队列研究。 具体来说，目标 1 将评估孕前期口腔健康和牙科服务使用的预测因素。 2 将利用目标试验框架来模拟随机对照试验来评估 患有牙周炎的女性在受孕前接受牙周炎治疗。 目标 3 将检查孕前牙周炎与自然流产（通常是 总的来说，拟议的项目有潜力提供广泛的见解 随附的培训计划与孕前期的女性口腔健康相吻合。 研究目标是为申请人提供强有力的实践培训机会，以支持她的过渡 具有观察研究方法专业知识的独立口腔健康流行病学家。 计划还概述了赞助商和共同赞助商提供的量身定制的指导机会，他们都是 各自领域公认的专家，具有与彼此以及与其他公司成功合作的记录 申请人。