Women's oral health in the preconception period: correlates and consequences

女性孕前期的口腔健康：相关性和后果

• 批准号: 10536354
• 负责人: Julia Craig Bond
• 金额: $ 3.69万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10536354
• 关键词: Academy; Address; Adult; Affect; Age; American; Birth; Canada; Centers for Disease Control and Prevention (U.S.); Chronic; Clinic; Clinical; Clinical Research; Clinical Trials; Cluster Analysis; Cohort Studies; Collaborations; Conceptions; Data; Dental Care; Dental Epidemiology; Diagnosis; Effectiveness; Enrollment; Epidemiologic Methods; Epidemiologist; Factor Analysis; Familiarity; Fellowship; Foundations; Goals; Health; Health Promotion; Health Services; Healthcare; Human; Inflammation; Inflammatory; Internet; Intervention; Lead; Link; Literature; Longitudinal Studies; Low Birth Weight Infant; Maternal and Child Health; Measures; Mentorship; Methods; Observation in research; Observational Study; Oral; Oral health; Outcome; Patient Self-Report; Periodontitis; Population; Population Heterogeneity; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnancy loss; Premature Birth; Prevalence; Prospective cohort study; Randomized Controlled Trials; Reporting; Reproductive Health; Research; Research Methodology; Research Personnel; Risk; Risk Factors; Sample Size; Selection Bias; Spontaneous abortion; Surveys; Techniques; Time; Tooth Loss; Training; United States; Validity of Self Report; Woman; adverse pregnancy outcome; base; behavior change; bone; cohort; design; early pregnancy; epidemiology study; evidence base; improved; insight; modifiable risk; novel; oral tissue; perinatal outcomes; pre-doctoral; pregnant; reproductive; skills; time-to-pregnancy; training opportunity

Project Abstract Periodontitis is the most common chronic health condition in humans and affects an estimated 38% of adult women in the United States. Research has demonstrated a connection between periodontitis and other adverse health outcomes, including reproductive health outcomes of preeclampsia, low birthweight, and preterm birth. However, trials evaluating periodontal treatment in pregnancy have not found a consistent benefit for perinatal outcomes, suggesting that establishment of oral health prior to pregnancy may be required to influence birth outcomes. Thus, research into oral health in the preconception period may provide important insights into potential opportunities for oral health promotion, particularly because attempting conception is often accompanied with behavior changes. Prior research by this investigator evaluating preconception oral health found an association between self-reported preconception periodontitis and a prolonged time-to- pregnancy, but the association between preconception periodontitis and other perinatal outcomes remains uncharacterized. The aim of this research is to address this gap in the literature by providing insights into the causes and consequences of oral health in the preconception period using data from a large, prospective cohort study that follows women from the time they are planning a pregnancy (e.g., preconception). Specifically, Aim 1 will assess predictors of oral health and dental service use in the preconception period. Aim 2 will leverage a Target Trial Framework to emulate a randomized controlled trial to evaluate the impact of preconception receipt of periodontitis treatment among women with periodontitis on time-to-conception. Finally, Aim 3 will examine the association between preconception periodontitis and spontaneous abortion (commonly referred to as miscarriage). Taken together, the proposed project has the potential to provide broad insights into women’s oral health in the preconception period. An accompanying training plan dovetails with the research objectives to provide robust, hands-on training opportunities for the applicant to support her transition to an independent oral health epidemiologist with expertise in observational research methods. The training plan additionally outlines tailored mentorship opportunities from the sponsor and co-sponsors, all of whom are recognized experts in their fields with a track record of successful collaboration with each other and the applicant.

项目摘要 牙周炎是人类最常见的慢性健康状况，估计有38％ 在美国的妇女。研究表明牙周炎与其他 不良健康结果，包括先兆子痫的生殖健康结果，低出生体重和 早产。但是，评估怀孕牙周治疗的试验尚未发现一致 围产期结局的益处，表明可能需要在怀孕前建立口腔健康 影响出生结果。这是对口腔健康的研究可能会提供重要的 洞悉口腔健康促进的潜在机会，尤其是因为尝试概念是 通常伴随着行为改变。该研究者的事先研究评估了口头牙 健康发现自我报告的牙周炎与长时间的时间之间的关联 怀孕，但是牙周炎和其他围产期结局之间的关联仍然存在 未表征。这项研究的目的是通过提供对文献的差距来解决这一差距 在先入期间使用大型，前瞻性的数据，口腔健康的原因和后果 从计划怀孕开始的女性开始（例如，先入为主）的队列研究。 具体而言，AIM 1将评估口腔健康和牙科服务使用的预测因素。目的 2将利用目标试验框架模仿随机对照试验，以评估 牙周炎妇女牙周炎的牙周炎治疗的牙周炎的牙周炎。最后， AIM 3将检查牙周炎和赞助堕胎之间的关联（通常 称为流产）。综上所述，拟议的项目有可能提供广泛的见解 在成念期间进入妇女的口腔健康。参加的培训计划与 研究目标，为申请人提供强大的动手培训机会，以支持她的过渡 具有观察性研究方法专家的独立口腔健康流行病学家。培训 另外计划概述赞助商和共同发起人的量身定制的精通机会，所有这些机会都是 在其领域的认可专家彼此成功合作的记录和 申请人。