Impact of vitamin D supplementation on cardiac structure and function

补充维生素 D 对心脏结构和功能的影响

基本信息

批准号：
9292464
负责人：
RAVI THADHANI
金额：
$ 3.22万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-03-01 至 2017-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9292464
关键词：
Impact vitamin supplementation cardiac structure

项目摘要

DESCRIPTION (provided by applicant): Experimental and observational data suggest that vitamin D supplementation reduces left ventricular hypertrophy and improves cardiac function. Prospective clinical data, however, are lacking. Thus, we propose an ancillary study to the Vitamin D and OmegA-3 Trial (VITAL) (U01CA138962), an outcomes trial of vitamin D supplementation in 20,000 men and women (aged ¿60 and 65 years, respectively). Because VITAL lacks any direct assessment of cardiac structure and function, we propose to perform cardiac imaging with echocardiography in 1,000 VITAL subjects pre-randomization and at 3 years. These data may answer several important questions that are not being addressed by the parent trial. Specifically, VITAL is focused on vascular endpoints (myocardial infarction, stroke), raising the possibility that important effects of vitamin D on the heart itself could be missed. Because there is compelling experimental evidence regarding the direct myocardial effects of vitamin D, assessment of cardiac structure and function would provide invaluable clinical and mechanistic insight, regardless of the outcome of the overall parent trial. The investigators have extensive experience in subclinical cardiovascular imaging, coordination of randomized trials (including the parent VITAL study), and clinical and experimental nutritional research. The study represents a unique and cost- effective opportunity to investigate measures of cardiac structure and function in a large, diverse primary prevention trial.

描述（由申请人提供）：实验和观察数据表明补充维生素 D 可减少左心室肥大并改善心脏功能，但缺乏前瞻性临床数据，因此，我们建议对维生素 D 和 OmegA-3 试验进行辅助研究。 (VITAL) (U01CA138962)，一项对 20,000 名男性和女性（60 岁和 60 岁）补充维生素 D 的结果试验由于 VITAL 缺乏对心脏结构和功能的任何直接评估，因此我们建议在随机分组前和 3 年时对 1,000 名 VITAL 受试者进行心脏成像，这些数据可能会回答母试验未解决的几个重要问题。 , VITAL 专注于血管终点（心肌梗塞、中风），由于存在关于维生素 D 对心肌的直接影响的令人信服的实验证据，因此无论结果如何，对心脏结构和功能的评估都将提供宝贵的临床和机制见解。研究人员在亚临床心血管成像、随机试验协调（包括母体 VITAL 研究）以及临床和实验营养研究方面拥有丰富的经验。该研究为研究心脏测量提供了一个独特且具有成本效益的机会。结构和功能在一个大的、多样化的一级预防试验。