7T Small Animal MRI Upgrade

7T小动物MRI升级版

• 批准号: 10630418
• 负责人: VINCENT A MAGNOTTA
• 金额: $ 60万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630418
• 关键词: 10 year old; Amplifiers; Animal Model; Animals; Biomedical Engineering; Brain; Cell Nucleus; Contract Services; Development; Disease; Electronics; Equipment; Faculty; Fees; Financial Support; Funding; Future; Grant; Heart; Hour; Image; Institution; Iowa; Libraries; Lung diseases; Magnetic Resonance Imaging; Malignant Neoplasms; Metabolism; Modernization; Nuclear; Performance; Physiologic pulse; Productivity; RF coil; Radiology Specialty; Research; Research Personnel; Research Support; Rodent; Source; Stroke; Structure; System; Tissues; United States National Institutes of Health; Universities; animal imaging; biomedical imaging; college; human imaging; imaging capabilities; imaging facilities; improved; novel; programs; pulmonary function; square foot; tool

The University of Iowa is requesting funds to upgrade our small animal 7T MRI scanner. The existing scanner is now more than 10 years old and several of the hardware components provided are no longer supported with replacement parts scarce. We are proposing an upgrade of the scanner by MR Solutions, which will replace a majority of the scanner electronics while reusing the superconducting magnet, gradient amplifiers (IECO), RF amplifiers (CPC), and RF coils (RapidMRI). The upgraded scanner will provide a number of significant improvements for animal imaging including: 1) higher performance gradients for rodent imaging; 2) support for imaging larger animals; 3) support for additional MR visible nuclei (129Xe and 13C); 4) increase the number of multi-nuclear capable channels from 1 to 8; 5) provide a modern pulse sequence library; and 6) ability to carry a service contract and source replacement parts. The upgraded system would continue to evolve as MR Solutions continues to develop their pulse sequence library and scanner tools. Finally, the upgraded scanner will provide a more stable platform, which is currently being used more than 170 hours per month with a majority of scanner hours in support for NIH grants. The MRRF serves as a Core University Facility and houses the only small animal imaging facilities in the State of Iowa. The scanner supports 18 investigators with 20 NIH funded grants and the addition of a larger gradient coil would enable imaging in larger animal models. The MRRF supports the research program of investigators from 6 colleges and 15 departments across campus. The facility also supports the research efforts from other state institutions (e.g. Iowa State University). These investigators are a highly productive group, which study a variety of diseases including brain development, stroke, heart/lung disease, and cancer. The MRRF is an active research group who are undertaking the development of novel imaging sequences to support our large number of users. This includes novel imaging sequences to assess 1) tissue microstructure, 2) brain function, 3) cancer, 4) lung function, and 5) metabolism. These projects would significantly benefit from the proposed scanner and provide future imaging capabilities for users of the facility. There is strong institution commitment for this equipment. The 7T small animal scanner is located in the $120 million Pappajohn Biomedical Discovery Building (PBDB) and the Iowa Institute for Biomedical Imaging (IIBI) was allocated 31,000 square feet of space in this building for human and animal imaging. To help support the scanner, the Department of Radiology and Biomedical Engineering have recently hired 3 additional faculty who are MR physicists. Finally, the Department of Radiology is providing more than $105,000 to cover the purchase of the upgrade and will provide financial support in case user fees are unable to cover expenses for the facility.

爱荷华大学正在申请资金升级我们的小动物 7T MRI 扫描仪。现有的 扫描仪已有 10 多年的历史，提供的一些硬件组件已不再可用 支持替换零件稀缺。我们建议 MR Solutions 对扫描仪进行升级， 将取代大部分扫描仪电子设备，同时重新使用超导磁体、梯度放大器 (IECO)、射频放大器 (CPC) 和射频线圈 (RapidMRI)。升级后的扫描仪将提供许多 动物成像的显着改进包括：1）啮齿动物成像的性能梯度更高； 2） 支持大型动物成像； 3) 支持额外的 MR 可见核（129Xe 和 13C）； 4）增加 多核通道数量从 1 到 8； 5）提供现代化的脉冲序列库；和 6) 有能力签订服务合同并采购替换零件。升级后的系统将继续 随着 MR Solutions 不断开发其脉冲序列库和扫描仪工具而不断发展。最后， 升级后的扫描仪将提供更稳定的平台，目前每个扫描仪的使用时间超过170小时 一个月的大部分扫描时间都用于支持 NIH 拨款。 MRRF 作为核心大学设施，拥有该地区唯一的小动物成像设施 爱荷华州。该扫描仪支持 18 名研究人员，获得 20 项 NIH 资助的赠款，并增加了更大的 梯度线圈将使更大的动物模型成像成为可能。 MRRF 支持的研究计划 来自校园内 6 个学院和 15 个系的调查员。该设施还支持研究 其他州立机构（例如爱荷华州立大学）的努力。这些调查员是高产的 该小组研究多种疾病，包括大脑发育、中风、心/肺疾病和癌症。 MRRF 是一个活跃的研究小组，致力于开发新颖的成像序列 支持我们大量的用户。这包括用于评估 1) 组织微观结构的新颖成像序列， 2) 脑功能，3) 癌症，4) 肺功能，5) 新陈代谢。这些项目将显着受益于 拟议的扫描仪并为该设施的用户提供未来的成像功能。 该设备有强有力的机构承诺。 7T小动物扫描仪位于 耗资 1.2 亿美元的帕帕约翰生物医学发现大楼 (PBDB) 和爱荷华州生物医学成像研究所 (IIBI) 在这座大楼内分配了 31,000 平方英尺的空间用于人类和动物成像。为了帮助支持 扫描仪、放射学和生物医学工程系最近又聘请了 3 名教职人员 他们是 MR 物理学家。最后，放射科提供超过 105,000 美元来支付 购买升级并将在用户费用无法支付费用的情况下提供财务支持 该设施。