Epidemiological and Statistical Methods Core (ESC)

流行病学和统计方法核心（ESC）

基本信息

批准号：
10663941
负责人：
KUNJAL PATEL
金额：
$ 60.55万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-18 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10663941
关键词：
Acceleration Address Adolescent Adult Advanced Development Bioinformatics Birth Brain region Child Childhood Clinic Clinical Cognitive Collaborations Complex Conceptions Continuing Education Correlation Studies Data Data Analyses Databases Development Disease remission E-learning Education Effectiveness Environment Epidemiologic Methods Epidemiologist Epidemiology Epigenetic Process Evaluation Evaluation Studies Faculty Formulation Fostering Genes Genetic Genomics Goals Graph Gynecologist HIV Health Hearing Image Immunologist Individual Informatics Language Longevity Measurement Mediation Mediator Mental Health Mentorship Methodology Methods Modification Monitor Mothers Nature Neurologist Observational Study Oral health Outcome Outcome Study Parameter Estimation Pediatric HIV/AIDS Cohort Study Pediatric epidemiology Perinatal Perinatal Epidemiology Persons Population Intervention Population Study Pregnancy Probability Program Research Project Grants Protocols documentation Research Research Design Research Personnel Research Project Grants Resources Risk Safety Sampling Scheme Series Site Social outcome Source Specialist Specific qualifier value Statistical Methods Time Toxic effect Training Weight Youth analytical method analytical tool behavioral outcome career case control cohort data resource deep learning algorithm design emotion regulation emotional behavior health determinants high dimensionality in utero informatics tool innovation interest longitudinal design microbiome multidisciplinary multilevel analysis neuroimaging novel pediatric human immunodeficiency virus pediatrician perinatal HIV prevent programs prospective social statistical service tool transmission process young adult

项目摘要

PROJECT SUMMARY The Pediatric HIV/AIDS Cohort Study (PHACS) is a large-scale multi-site network with multiple observational studies aimed to evaluate the long-term effectiveness and safety of population-based interventions to prevent perinatal HIV transmission and HIV progression and inform HIV remission/cure strategies. The PHACS Research Projects have generated and will continue to gather data on health determinants from various sources and via diverse methods including clinical, social, genomic, microbiome, and imaging data. A multitude of concept sheets and sub-studies will therefore be proposed requiring specialized epidemiological and statistical expertise, ranging from efficient study design, causal inference methodology, deep learning algorithms, bioinformatics, and integrative microbiome informatics, to inform data analyses that will be conducted by the PHACS Data Resources Core (DRC). As we continue to add to our extensive PHACS database, new and challenging problems are likely to arise that may necessitate the development of innovative study designs and analytic methods, particularly in the fields of pediatric and perinatal epidemiology. Ongoing training will be required on these and other methodological innovations for PHACS epidemiologists and statisticians. Continuing education on fundamental epidemiological and statistical principles will also be required for all PHACS investigators in order to conduct effective collaborative research. To address these needs and promote valid and efficient pediatric and perinatal HIV research within the Research Projects and any focused Emerging Research Pilots, the PHACS Epidemiological and Statistical Methods Core (ESC) has been established to: (1) provide specialized epidemiological and statistical services, support, and resources; (2) promote the development and application of novel epidemiological and statistical methods; and (3) support continuing education in epidemiological and statistical methods through in-person or web-based training and mentorship of early career investigators.

项目概要儿科艾滋病毒/艾滋病队列研究 (PHACS) 是一个大规模的多站点网络，具有多个观察组研究旨在评估基于人群的干预措施的长期有效性和安全性，以预防围产期艾滋病毒传播和艾滋病毒进展，并为艾滋病毒缓解/治愈策略提供信息。 PHACS 研究项目已经并将继续收集来自不同领域的健康决定因素的数据来源和通过多种方法，包括临床、社会、基因组、微生物组和成像数据。众多因此，将提出概念表和子研究，需要专门的流行病学和统计专业知识，包括高效的研究设计、因果推理方法、深度学习算法、生物信息学和综合微生物组信息学，为数据分析提供信息由 PHACS 数据资源核心 (DRC) 进行。随着我们不断增加我们广泛的 PHACS 数据库中，可能会出现新的和具有挑战性的问题，可能需要开发创新的研究设计和分析方法，特别是儿科和围产期流行病学领域。进行中需要对 PHACS 流行病学家和其他方法创新进行培训统计学家。基本流行病学和统计原理的继续教育也将所有 PHACS 研究人员都需要这样做，以便进行有效的合作研究。为了满足这些需求并促进有效和高效的儿科和围产期艾滋病毒研究研究项目和任何重点新兴研究试点、PHACS 流行病学和统计建立方法核心 (ESC) 的目的是：(1) 提供专门的流行病学和统计服务，支持和资源；（二）推动新型流行病学和统计技术的开发和应用方法; (3) 通过面对面或其他方式支持流行病学和统计方法的继续教育对早期职业调查员进行基于网络的培训和指导。