From RRID to Resource Watch: A Knowledgebase of Biomedical Research Resources

从 RRID 到资源观察：生物医学研究资源知识库

• 批准号: 10664832
• 负责人: Anita ELZBIETA Bandrowski
• 金额: $ 55.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664832
• 关键词: Antibodies; Biomedical Research; Cell Line; Collaborations; Communication; Communities; Computer software; Core Facility; Data; Databases; Decision Making; Ensure; Funding; Goals; Growth; Harvest; Individual; Information Networks; Infrastructure; Journals; Literature; Measurable; National Institute of Diabetes and Digestive and Kidney Diseases; Neurosciences; Nonprofit Organizations; Organism; Paper; Plasmids; Process; Reagent; Registries; Reproducibility; Research; Research Personnel; Research Project Summaries; Research Support; Resources; Role; Science; Scientist; Source; Specific qualifier value; Specificity; Structure; Time; United States National Institutes of Health; Universities; Validation; Writing; biomedical scientist; central database; digital; improved; indexing; information framework; information gathering; knowledge base; knowledge curation; knowledge integration; knowledgebase; model organisms databases; outreach; text searching; tool; web portal

Project Summary Research Resource Identifiers, RRIDs, are persistent identifiers for key research resources such as antibodies, cell lines, organisms and digital assets. They are in use in over 1300 biomedical journals and are supplied by authors to uniquely identify which resources are used within a study. The RRID project was launched as a grass- roots effort in 2014 to improve the identifiability of research resources in the biomedical literature. RRIDs depend on the collaboration of journals with comprehensive registries and stock centers, which provide an authoritative identifier for each resource type. The introduction of RRIDs has had a significant impact on our ability to identify and track the use of research resources in the biomedical literature. Papers that use RRIDs have improved identifiability of resources from <50% to >90%. RRIDs make it easier to track usage, assign credit, and aggregate information about how resources perform in the literature. Towards that end, we have assembled a curated knowledge base that provides information on RRID use in the literature. Because RRIDs are served from a central database which is used broadly by scientists as they write their papers, the portal can also serve as a central hub for disseminating critical information about how such reagents perform. For example, the RRID portal provides warnings on contaminated cell lines provided by Cellosaurus. However, such information on other types of resources is much more dispersed. Therefore, we built a related knowledge base, Resource Watch, that enhances the information about RRIDs. The RRID project has been bootstrapped on top of existing NIH-funded projects, but given its growth and importance to biomedicine, we seek to unify the current RRID project into a self-supporting entity.

项目摘要 研究资源标识符，rrids是抗体等关键研究资源的持久标识符， 细胞系，生物和数字资产。它们在1300多个生物医学期刊中使用，由 作者唯一地确定研究中使用了哪些资源。 RRID项目是作为基层启动的 扎根于2014年提高生物医学文献中研究资源的可识别性。 rrids取决于 关于期刊与全面的登记处和股票中心的合作，这些注册表和股票中心提供了权威 每个资源类型的标识符。 RRID的引入对我们识别的能力产生了重大影响 并跟踪生物医学文献中研究资源的使用。使用RRID的论文有所改善 资源从<50％到> 90％的可识别性。 RRID使跟踪使用，分配信用和汇总变得更容易 有关资源在文献中的表现的信息。为此，我们组装了一个精选的 提供有关文献中RRID使用信息的知识库。因为rrids是从一个 中央数据库由科学家在撰写论文时广泛使用，该门户网站也可以用作 用于传播有关此类试剂的关键信息的中央枢纽。例如，RRID门户 在大提琴库提供的污染细胞系上提供警告。但是，有关其他类型的此类信息 资源的分散得多。因此，我们建立了一个相关的知识库，资源观察， 增强有关RRID的信息。 RRID项目已在现有NIH资助的顶部引导 项目，但鉴于其对生物医学的增长和重要性，我们试图将当前的RRID项目统一为 自我支持的实体。