The Impact of Social, Genetic and Neuroimaging Factors on Cognitive Functioning in the Black Community

社会、遗传和神经影像因素对黑人社区认知功能的影响

• 批准号: 10664484
• 负责人: Kacie Deters
• 金额: $ 21.47万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664484
• 关键词: Admixture; Affect; African; African American; African ancestry; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Apolipoprotein E; Area; Biological; Biological Markers; Biology; Birth; Black American; Black Populations; Black race; Blood Vessels; Brain; Brain region; Clinical; Cognition; Cognitive; Cognitive aging; Communities; Competence; County; Data; Dementia; Disease; Education; Enrollment; European ancestry; Fathers; Future; Genes; Genetic; Goals; Heterogeneity; Impaired cognition; Impairment; Income; Individual; Knowledge; Life; Life Cycle Stages; Location; Longevity; Los Angeles; Magnetic Resonance Imaging; Measures; Mediating; Memory; Mentored Research Scientist Development Award; Mentors; Mentorship; Methodology; Minority; Mothers; Nerve Degeneration; Neuropsychological Tests; Neuropsychology; Not Hispanic or Latino; Participant; Pathologic; Population; Population Heterogeneity; Populations at Risk; Positioning Attribute; Prevention; Race; Research; Research Personnel; Risk; Risk Factors; Science; Socioeconomic Status; Symptoms; Testing; Training; Training Activity; Variant; White Matter Hyperintensity; apolipoprotein E-4; biological heterogeneity; brain health; childhood adversity; cognitive function; cohort; community engagement; disparity reduction; ethnic disparity; experience; genetic risk factor; health disparity; high risk; member; mild cognitive impairment; multidisciplinary; neighborhood disadvantage; neural correlate; neurocognitive test; neuroimaging; neuroimaging marker; non-demented; perceived discrimination; prevent; racial disparity; racial population; research study; risk prediction; skills; social; social disparities; social factors; tool

PROJECT SUMMARY The applicant seeks this K01 award to gain expertise on integrating social factors and neuropsychological assessments to examine within race heterogeneity for cognitive decline risk factors in the Black community. To achieve these goals, the applicant plans to leverage her strength is quantitative methodology for biomarker data to gain expertise in four critical areas of training: (1) research neuropsychological testing and community engagement; (2) health disparities and lifecourse factors; (3) genetics; and (4) professional training. With the guidance from her expert mentorship team and through a detailed training plan, the applicant will develop an in-depth knowledge in these training areas and enable the applicant to be well positioned to successfully complete the proposed aims of the K01. The overall research goal of this K01 application is to determine how social, neuroimaging markers, and genetic risk factors contribute to cognitive decline in non-demented older Black individuals. Research suggests current “well-established” risk factors for cognitive decline and Alzheimer’s disease (AD), which have been identified primarily in the white community, do not behave the same in Black individuals. Thus, it is critical to explore potential heterogeneity in risk factors within the Black community in order to accurately predict risk for cognitive decline. The first part of aim 1 examines the effect of early and current social factors on neuroimaging measures that have previously been associated with cognition (e.g. structural magnetic resonance imaging measures and vascular burden measured as white matter hyperintensities) in self-identified non-Hispanic Black participants. The second part of aim 1 will determine if these neuroimaging markers mediate the association of social factors and cognitive decline. We hypothesize that more social disadvantage will be inversely associated with AD-specific brain regions and faster rates of cognitive decline. We also hypothesize that neuroimaging measures will partially mediate the association of social factors on cognitive decline. Differences in racial groups may be due to social factors, which members of the Black community are disproportionately impacted. Finally, it is important to remember that race is a social construct and is dependent on self-identification, with no biological root. Moreover, recent studies suggest that genetic ancestry may influence risk for AD and impact pathological features of aging. It is unclear if genetic ancestry and social factors correlate, or if they have unique contributions to cognitive decline. Thus, our final aim will determine if genetic ancestry and/or social factors differentially influence the effect of APOE4 on cognitive decline. The primary hypothesis is that Black participants with more social disadvantage throughout life, will inversely effect these risk factors and have a faster rate of cognitive decline. We will also investigate if this association impacts conversion from mild cognitive impairment to AD dementia. Completion of these aims, along with the training from an experienced multidisciplinary mentoring team, will generate data and support for a future R01 application collecting data from members of the Black community in Los Angeles County.

项目摘要 申请人寻求该K01奖，以获得整合社会因素和神经心理学的专业知识 评估黑人社区的认知下降危险因素内种族异质性的评估。到 实现这些目标，申请人计划利用她的力量是生物标志物的定量方法 在培训的四个关键领域中获得专业知识的数据：（1）研究神经心理学测试和社区 订婚; （2）健康差异和生命力因素； （3）遗传学； （4）专业培训。与 她的专家Mentalship团队的指导以及通过详细的培训计划，申请人将开发 在这些培训领域的深入知识，使申请人能够得到良好的位置 完成K01的拟议目标。该K01应用的总体研究目标是确定如何 社会，神经影像标记和遗传危险因素导致未痴呆的老年人认知下降 黑人。研究表明，当前的认知下降和 阿尔茨海默氏病（AD）主要在白人社区中被识别 黑人个人也一样。这是至关重要的 社区以准确预测认知能力下降的风险。 AIM 1考试的第一部分是 早期和当前的社会因素与以前与认知有关的神经影像措施 （例如，结构磁共振成像测量和以白质测量的血管燃烧 超强度）在自我识别的非西班牙裔黑人参与者中。 AIM 1的第二部分将确定是否 这些神经成像标记介导了社会因素和认知能力下降的关联。我们假设 更多的社会灾难将与特定于广告的大脑区域成反比 认知能力下降。我们还假设神经影像措施将部分介导 认知能力下降的社会因素。种族群体的差异可能是由于社会因素造成的，哪些成员 黑人社区受到不成比例的影响。最后，重要的是要记住种族是一个社会 构建并取决于自我识别，没有生物根。此外，最近的研究表明 遗传血统可能会影响AD的风险和影响衰老的病理特征。目前尚不清楚是否遗传 祖先和社会因素相关，或者是否对认知能力下降有独特的贡献。那，我们的决赛 AIM将确定遗传血统和/或社会因素是否对APOE4的影响有所不同 认知能力下降。主要假设是整个过程中都有更多社交灾难的黑人参与者 生活，将成反影响这些危险因素，并具有更快的认知能力下降速度。我们还将调查是否 该关联影响从轻度认知障碍转变为AD痴呆症。这些目标的完成， 除了经验丰富的多学科指导团队的培训外，还将生成数据并支持 未来的R01应用程序从洛杉矶县黑人社区的成员收集数据。