Southern California Clinical and Translational Science Institute

南加州临床与转化科学研究所

• 批准号: 10559463
• 负责人: Thomas A Buchanan
• 金额: $ 900.97万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559463
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Contact PD/PI: Buchanan, Thomas A OVERALL COMPONENT Project Summary/Abstract The Southern California Clinical and Translational Science Institute (SC CTSI) is submitting this revision for a third cycle of Clinical and Translational Science Award (CTSA) funding at a time of dramatic growth and opportunity at our hub. The SC CTSI encompasses the University of Southern California (USC) and Children's Hospital of Los Angeles (CHLA), in close partnership with the Los Angeles County Department of Health Services. Our vision is to be a leader in clinical and translational research to benefit diverse communities and special populations. Our approach builds on past success, acknowledging the changing landscape of clinical and translational research (CTR), the priorities of the CTSA program, and the evolving needs of our researchers, trainees, patients and communities. Our scope leverages strengths in clinical, health system, and community research, education and training, within two overarching themes: diversity and impact. Diversity is reflected in the communities, health systems, and scientific disciplines we engage to improve health care and outcomes. Impact encompasses academic productivity as well as benefit to our workforce, health systems, patients, and communities. To pursue our vision in the context of our scope and themes, we propose six specific aims: (1) Workforce Development: Train a highly skilled workforce with the knowledge, skills, and attitudes to conduct rigorous and reproducible research focused on the evolving health needs of diverse communities. (2) Collaboration and Engagement: Create a culture in which team-based research, engaging all stakeholders and following sound principles of team science, is the standard approach to addressing complex challenges in health and research. (3) Integration: Engage our diverse communities to establish clinical research priorities; identify barriers to research; and develop, demonstrate and disseminate innovative approaches to assure fully partnered clinical research across communities and the lifespan. (4) Methods and Process: Apply principles of quality and process improvement to clinical and translational research to develop and share novel approaches to enhance efficiency, quality and impact. (5) Informatics: Provide an agile information ecosystem that encompasses research, clinical care, communities and their environment, providing a holistic view of health and disease and serving as the engine for discovery, innovation and insight. (6) CTSA Hub: Participate in CTSA network activities, conduct multi-site studies, adopt successful models from peers, and develop, demonstrate and disseminate innovative approaches. Achieving these aims will advance the discipline of CTR directed at improving health in diverse and underserved communities. Glossary ACT – CTSA Program Accrual to Clinical Trials Network IRB – Institutional Review Board BERD – Biostatistics, Epidemiology, Research Design core group ISI – USC Information Sciences Institute CD2H – CTSA Program National Center for Data to Health IT – Information Technology CE – Community Engagement core group KSOM – Keck School of Medicine of USC CEREC – CTSA External Reviewer Exchange Consortium LA – Los Angeles CHDP – Community Health Demonstration Projects LAC DHS – LA County Department of Health Services CHLA – Children's Hospital Los Angeles LGBTQ+ – Lesbian, Gay, Bisexual, Transgender, Questioning CLIC – CTSA Center for Leading Innovation and Collaboration MRC – Mentor Resource Center CLS – Community Listening Session N3C – National COVID Cohort Collaborative CRI – Clinical Research Informatics core group NGHP – Nickerson Gardens Housing Project CSU – Colorado State University NIH – National Institutes of Health CSULA – California State University Los Angeles NLP – Natural Language Processing CTR – Clinical and Translational Research OC/OH-LA – Our Community/Our Health Los Angeles CTTI – Clinical Trials Transformation Initiative PBRN – Practice-Based Research Network DIAMOND – Development, Implementation, and Assessment of Novel Training in Domain-based Competencies Portal QbD – Quality by Design EAC – External Advisory Committee SC CTSI – Southern California Clinical and Translational Science Institute EDWAP – Enterprise Data Warehouse and Analytics Platform SEDoH – Social and Environmental Determinants of Health EHR – Electronic Health Record SNA – Social Network Analysis ERC – Education Resource Center SSI – USC Spatial Sciences Institute FHIR – Fast Healthcare Interoperability Resources STELLAR – Self Career Training Education Lifelong Learning Advancement Resource, a collaboration with Georgia CTSA HACLA – Housing Authority of the City of Los Angeles TBV – Team Building Voucher HDS – Healthcare Delivery Science TIN – Trial Innovation Network HHS – Hollywood, Health & Society TS – Team Science I2b2 – Informatics for Integrating Biology & the Bedside UCLA – University of California Los Angeles ICD – Institutional Career Development URM – Under-Represented in Medicine IIT – Investigator-Initiated Trial USC – University of Southern California IOB – Internal Oversight Board WD – Workforce Development core group Project Summary/Abstract Page 207 Contact PD/PI: Buchanan, Thomas A UL1

联系PD/PI：Buchanan，Thomas A 总体组件 项目摘要/摘要 南加州临床和转化科学研究所（SC CTSI）正在将此修订提交 临床和转化科学奖（CTSA）的第三个周期，在急剧增长和 在我们的枢纽。 SC CTSI涵盖了南加州大学（USC）和儿童 洛杉矶医院（CHLA）与洛杉矶县卫生部密切合作 服务。我们的愿景是成为临床和翻译研究的领导者，以使各种社区和 特殊人群。我们的方法以过去的成功为基础，承认临床的不断变化 并翻译研究（CTR），CTSA计划的优先事项以及我们的不断发展的需求 研究人员，学员，患者和社区。我们的范围利用临床，卫生系统和 社区研究，教育和培训，在两个总体主题中：多样性和影响。多样性是 反映在我们参与的社区，卫生系统和科学学科中，以改善医疗保健和 结果。影响包括学术生产力以及对我们的劳动力，卫生系统， 病人和社区。在我们的范围和主题的背景下追求我们的愿景，我们提出六个 具体目的：（1）劳动力发展：培训具有知识，技能和 进行严格且可重复的研究的态度，重点是潜水员的健康需求不断发展 社区。 （2）协作与参与：创建一种基于团队研究的文化，参与所有人 利益相关者和遵循团队科学的合理原则，是解决复杂问题的标准方法 健康和研究的挑战。 （3）整合：让我们的潜水员社区建立临床 研究重点；确定研究障碍；并发展，演示和传播创新 确保在社区和寿命之间确保完全合作的临床研究的方法。 （4）方法和 过程：将质量和过程改进的原则应用于临床和翻译研究以发展 并分享新颖的方法，以提高效率，质量和影响。 （5）信息学：提供敏捷 提供研究，临床护理，社区及其环境的信息生态系统，提供 对健康和疾病的整体观点，并作为发现，创新和见识的引擎。 （6）CTSA 集线器：参加CTSA网络活动，进行多站点研究，采用同行的成功模型， 并发展，演示和传播创新的方法。实现这些目标将促进 CTR的学科致力于改善潜水员和服务不足的社区的健康。 词汇表 ACT - 临床试验网络IRB的CTSA计划累计 - 机构审查委员会 BERD - 生物统计学，流行病学，研究设计核心小组ISI - USC信息科学研究所 CD2H - CTSA计划国家数据中心健康IT - 信息技术 CE - 社区参与核心小组KSOM - USC凯克医学院 CEREC - CTSA外部审稿人交流财团LA - 洛杉矶 CHDP - 社区健康示范项目LAC DHS - 洛杉矶县卫生服务部 CHLA - 儿童医院洛杉矶LGBTQ+ - 女同性恋，同性恋，双性恋，变性人，询问 CLIC - CTSA领先创新与协作中心MRC - 导师资源中心 CLS - 社区听力会议N3C - 国家共同队列合作 CRI - 临床研究信息学核心组NGHP - 尼克森花园住房项目 CSU - 科罗拉多州立大学NIH - 国立卫生研究院 Csula - 加利福尼亚州立大学洛杉矶NLP - 自然语言处理 CTR - 临床和转化研究OC/OH-LA - 我们的社区/我们的健康洛杉矶 CTTI - 临床试验转换计划PBRN - 基于实践的研究网络 钻石 - 开发，实施和评估 基于域的能力门户QBD的新颖培训 - 设计质量 EAC - 外部咨询委员会 SC CTSI - 南加州的临床和翻译 科学研究所 EDWAP - 企业数据仓库和分析平台SEDOH - 健康的社会和环境决定因素 EHR - 电子健康记录SNA - 社交网络分析 ERC - 教育资源中心SSI - USC空间科学学院 FHIR - 快速医疗保健互操作性资源 出色 - 自我职业培训教育终生学习 Advancement Resources，与佐治亚州CTSA的合作 Hacla - 洛杉矶市TBV市的住房管理局 - 团队建设代金券 HDS - 医疗保健交付科学锡 - 试验创新网络 HHS - 好莱坞，健康与社会TS - 团队科学 I2B2 - 整合生物学和床头UCLA的信息学 - 加利福尼亚大学洛杉矶分校 ICD - 机构职业发展URM - 医学的代表性不足 IIT - 调查员发动的审判USC - 南加州大学 IOB - 内部监督委员会WD - 劳动力发展核心小组 项目摘要/摘要页面207 联系PD/PI：Buchanan，Thomas A UL1