Bruins in Genomics: Dental, Oral & Craniofacial Research Training Program (BIG DOC)

基因组学中的棕熊：牙科、口腔

• 批准号: 10540402
• 负责人: Alexander Hoffmann
• 金额: $ 25.7万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10540402
• 关键词: Address; Area; Big Data; Biological; Biological Sciences; Biology; Biomedical Research; Chromosome Mapping; Communities; Data; Data Analyses; Data Science; Dedications; Dental; Dentistry; Dentists; Development; Diagnosis; Disease; Doctor of Philosophy; Educational workshop; Ethnic Population; Faculty; Funding; Future; Generations; Genome; Genomics; Goals; Health; Health Sciences; Historically Black Colleges and Universities; Human Biology; Infrastructure; Learning; Medical; Medicine; Mentored Clinical Scientist Development Program; Mentors; Mentorship; Mining; Minority-Serving Institution; National Institute of Dental and Craniofacial Research; Oral; Oral health; Participant; Pathology; Public Health; Rehabilitation therapy; Research; Research Personnel; Research Priority; Research Project Grants; Research Training; Residencies; Risk; Risk Management; Science; Scientist; Sequence Analysis; Series; Societies; Students; Technology; Training; Training Programs; Underrepresented Minority; Underrepresented Populations; career; career development; clinical care; clinical decision-making; clinical practice; cohort; craniofacial; deaf; disability; disadvantaged background; education research; experience; genome sciences; hands on research; health disparity; high throughput screening; mid-career faculty; next generation; next generation sequence data; next generation sequencing; personalized care; personalized medicine; programs; racial population; recruit; science teacher; skills; student training; summer program; summer research; summer student; undergraduate research experience; undergraduate student

The proposed R25-NIDCR Research Education in Genomics Training Program with Diversity Action Plan (DAP) is to provide summer research experience in Genomic Sciences, Medicine and Society in dental, oral and craniofacial areas with a special emphasis on analysis of next generation sequences (NGS) for 20 undergraduate students from diverse backgrounds, specifically students from racial and ethnic groups underrepresented in biomedical research, with disabilities, and from disadvantaged backgrounds. NGS has revolutionized biosciences and biomedical research and is on the verge of transforming clinical practice. It is critical to train a new and diverse generation of biological and quantitative dentist scientists and oral health researchers for mining this vast amount of public data in order to address current challenges to public health. Data science has transformed the field of medical genomics and is likely to permeate all aspects of dentistry from risk management to the bedside through personalized treatment decisions on dental, oral and craniofacial diseases. We anticipate a critical need for dental researchers with strong skills in big data analysis, with particular emphasis on genomics. This need is further emphasized in the requirements of quantitative analysis skills in biosciences graduate programs, DDS/PhD programs (T32, T90/R90), Post-DDS Residency/PhD program (K12) programs all the way to the practice of dentistry. To address the need in dental, oral and craniofacial science for researchers and practitioners from diverse backgrounds with strong data science skills, we will establish the “Bruins-In-Genomics in Dental, Oral and Craniofacial Research Training Program (BIG DOC)”. This program will leverage the infrastructure of the existing, highly successful UCLA “Bruins-In-Genomics (BIG)” Summer Undergraduate Research Program (BIG Summer)” which is hosted by the Institute for Quantitative and Computational Biosciences (QCB) at UCLA. BIG Summer consists of a combination of practical workshop tutorials that focus on NGS data analysis skills, and a hands-on research experience with UCLA faculty in genomic sciences, medicine and society. The proposed R25-NIDCR BIG DOC program will fund 20 students to join the existing BIG Summer program and partner with faculty with a research focus in dental, oral and craniofacial genomics. The students will be quantitative or biosciences majors entering their junior and senior years. We expect that for many of our participants, this research experience will serve as a launching point for their research careers and career development in dental, oral and craniofacial research. Program recruitment will emphasize academic excellence, enthusiasm, diversity and underrepresented minorities.

拟议的R25-NIDCR研究教育在基因组学培训计划中具有多样性行动计划（DAP） 是在牙科，口服和 颅面区域特别强调了20个本科生的下一代序列（NGS） 来自潜水员背景的学生，特别是来自种族和族裔群体的学生的人数不足 生物医学研究，残疾和来自弱势背景。 NGS彻底改变了生物科学和生物医学研究，即将改变临床 实践。培训一系列新的生物学和定量牙医科学家以及 口头健康研究人员开采这大量公共数据，以应对当前的挑战 公共卫生。数据科学改变了医学基因组学领域，可能会渗透到各个方面 从风险管理到床边的牙科，通过对牙齿，口服和的个性化治疗决策 颅面疾病。我们预计在大数据分析方面具有强大技能的牙科研究人员的迫切需求， 特别强调基因组学。在定量的要求中进一步强调了这种需求 生物科学研究生课程，DDS/PHD计划（T32，T90/R90）的分析技能 居住/博士学位计划（K12）一直到牙科实践。 解决牙科，口腔和颅面科学的需求，对潜水员的研究人员和从业者 具有强大数据科学技能的背景，我们将建立“牙科，口服和 颅面研究培训计划（BIG DOC）”。该计划将利用 现有的，非常成功的加州大学洛杉矶分校“基因组熊（大）”夏季本科研究计划（BIG） 夏季）”由UCLA的定量和计算生物科学研究所（QCB）主持。 夏季由专注于NGS数据分析技能的实用研讨会教程组成， 在基因组科学，医学和社会中，UCLA教师的动手研究经验。提议 R25-NIDCR Big Doc计划将资助20名学生参加现有的大夏季计划，并与 教师研究重点是牙科，口腔和颅面基因组学。学生将是定量的或 Biosciences专业进入大三和高年级。我们希望对于许多参与者， 研究经验将成为其研究职业和牙科职业发展的启动点， 口腔和颅面研究。计划招聘将强调学术上的卓越，热情，多样性 和代表性不足的少数民族。