Clinical and Diagnostics Core

临床和诊断核心

基本信息

批准号：
10540802
负责人：
George Richard Thompson
金额：
$ 22.9万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-01-01 至 2026-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10540802
关键词：
Antifungal Agents Antigens Bioinformatics Biological Assay Biometry Blood specimen California Caring Catchment Area Center for Translational Science Activities Clinic Clinical Clinical Data Clinical Management Clinical Research Clinical Sciences Clinical Trials Coccidioides Coccidioidomycosis Collaborations Collection Communicable Diseases Communities Computerized Medical Record Conduct Clinical Trials Consent Data Data Coordinating Center Data Set Databases Diagnosis Diagnostic Diagnostic tests Disease Drug Industry Enrollment Evaluation Genomics Health Human Immune Incidence Infection Infrastructure Internal Medicine Intervention Investigation Laboratories Lead Life Link Lung infections Medical History Metabolic Molecular Monitor Morbidity - disease rate Outcome Participant Pathogenesis Pathogenicity Pathway interactions Patients Peripheral Blood Mononuclear Cell Pharmacy facility Play Predisposition Procedures Public Health Pulmonology Reagent Research Research Personnel Research Support Resources Retrieval Role Sampling Serodiagnoses Serology Serum Severity of illness Source Technology Therapeutic Translational Research Treatment outcome United States National Institutes of Health Validation Vulnerable Populations Work base biobank biomarker identification biosignature candidate identification clinical care desert fever diagnostic assay diagnostic tool empowerment exome sequencing experience metabolomics mortality novel diagnostics participant enrollment pathogen peripheral blood preservation programs radiological imaging repository research study response sample collection transcriptomics validation studies

项目摘要

Summary Core 3: Clinical and Diagnostics Core Co-Directors: (Thompson and Kenyon) The Core 3 will provide infrastructure and assays to support interdisciplinary discovery and translational research objectives proposed in the Projects of this application. The Core 3 resources will support the investigation of immune and metabolic correlates of the spectrum of disease encountered in coccidioidomycosis and treatment outcomes (Project 3). Through the collection of CSF and peripheral blood samples, Core 3 will provide samples for investigating host transcriptomic response in disseminated Coccidioides (Project 2). Core 3 will support an evaluation of the diagnostic potential of Coccidioides antigens identified in Projects 1 and 2 and host biomarkers identified in Project 2. The Specific Aims of the Core 3 are the following: (1) To develop Coccidioides patient sample repositories that link to clinical patient information through unique databases that support discovery and translational research on coccidioidomycosis. (2) To increase coccidioidomycosis research collaborations by leveraging resources available through the UC Davis Clinical and Translational Science Center (CTSC), West Coast Metabolomics Center (WCMC) and other technology cores. In summary, Core 3 will play a critical role in supporting the research investigations for the Projects 1, 2 and 3 by providing well defined clinical samples from patients with Coccidioides infection. In collaboration with the CTSC, Core 3 will provide clinical (deidentified) data and serological findings from the Coccidioidomycosis Diagnostic laboratory. Thus, Core 3 will serve as an important source of the clinical samples including serum, CSF and PBMC samples. Additionally, Core 3 will evaluate the diagnostic potential of Coccidioides antigens identified in the Projects 1 and 2 and host biomarkers identified in Project 2. If these candidates show promise, further studies will be performed through the Diagnostic laboratory so that these reagents can be advanced to the clinic.

概括核心 3：临床和诊断核心联合主任：（Thompson 和 Kenyon） Core 3 将提供基础设施和分析方法来支持跨学科发现和转化研究本应用程序的项目中提出的目标。核心 3 资源将支持以下调查：球孢子菌病和治疗中遇到的疾病谱的免疫和代谢相关性结果（项目 3）。通过采集脑脊液和外周血样本，Core 3将提供样本用于研究播散性球孢子菌的宿主转录组反应（项目 2）。 Core 3 将支持评估项目 1 和 2 中鉴定的球孢子菌抗原和宿主生物标志物的诊断潜力项目 2 中确定。核心 3 的具体目标如下： (1) 开发球孢子菌患者样本库，通过独特的数据库链接到临床患者信息，支持发现和转化研究球孢子菌病。（二）发挥资源优势，加强球孢子菌病研究合作可通过加州大学戴维斯分校临床和转化科学中心 (CTSC)、西海岸代谢组学获得中心（WCMC）等技术核心。总之，核心3将在支持项目1、2和3的研究调查中发挥关键作用通过提供来自球孢子菌感染患者的明确临床样本。与合作 CTSC，核心 3 将提供球孢子菌病的临床（未识别）数据和血清学结果诊断实验室。因此，Core 3将作为临床样本的重要来源，包括血清、 CSF 和 PBMC 样本。此外，Core 3 将评估球孢子菌抗原的诊断潜力项目 1 和 2 中确定的生物标志物以及项目 2 中确定的宿主生物标志物。如果这些候选者表现出希望，进一步的研究将通过诊断实验室进行，以便这些试剂可以先进到诊所。