BD2K: INTEROPERABILITY OF NURSA WITH PHARMGKB AND DKNET

BD2K：NURSA 与 PARMGKB 和 DKNET 的互操作性

• 批准号: 9057203
• 负责人: RONALD M EVANS
• 金额: $ 27.44万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-17 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9057203
• 关键词: Academia; Achievement; Androgen Receptor; Anthelmintics; Atlases; Bioinformatics; Cells; Circadian Rhythms; Communities; Complex; Computer software; Data Analyses; Data Set; Data Sources; Development; Diabetes Mellitus; Discipline; Disease; Endocrinology; Funding; Funding Mechanisms; Funding Opportunities; Gene Targeting; Generations; Genes; Genome; Genomics; Government; Health; Hematology; Individual; Industry; Inflammation; Institutes; Internet; Investments; Journals; Literature; Macrophage Activation; Malignant Neoplasms; Measures; Metabolic Pathway; Metabolism; Methods; Molecular; Molecular Profiling; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Environmental Health Sciences; Nature; Neurosciences; Nuclear Receptors; Obesity; Output; Paper; Peptides; Phage Display; Proteomics; Protocols documentation; PubMed; Publications; Publishing; Receptor Signaling; Regulation; Research; Research Personnel; Research Project Grants; Resources; Role; Science; Site; Software Tools; Techniques; Testing; Therapeutic; Time; Tissues; United States National Institutes of Health; Validation; Visit; Writing; base; bone; catalyst; cell growth regulation; chromatin modification; epigenomics; inhibitor/antagonist; interoperability; member; metabolomics; nervous system disorder; novel; outreach; programs; promoter; protein protein interaction; response; senescence; small molecule; sound; success; therapeutic target; tool; transcriptomics; tumor metabolism; user-friendly; web site

Over the past decade the field of NR signaling has generated a large volume of global datasets that collectively describe sequences of NR and coregulator genes (genomics); the regulation by NRs and coregulators of gene networks in specific target tissues (transcriptomics); protein-protein interactions required for the efficient function of NRs and coregtjiators (proteomics); specific sites of action of NRs in target gene promoters (cistromics); covalent modification of chromatin (epigenomics); and, more recently, specific functional endpoints in the form of regulation of cellular metabolic pathways (metabolomics). In order to effectively leverage these resources, we propose the continued development ofthe Nuclear Receptor Signaling Atlas (NURSA) web resource that will assemble and integrate these datasets, build user-friendly data analysis tools and present these to the community for hypothesis generation and validation. To fully engage the research community, we propose to administer a program of NURSA Data Source Projects (NDSPs) that will generate new global scale datasets that will be submitted to the website and integrated with existing datasets. We will also engage in outreach efforts that will offer members of the research community to participate in NURSA as Affiliate members, as well as in testing software tools during their development. With the involvement of the community, we anticipate that NURSA will be an important research resource for this field. RELEVANCE (See instructions): Nuclear receptors (NRs) and coregulators are important therapeutic targets in many different disease states including cancer, obesity, diabetes, inflammation, neurological disorders and senescent diseases. This application proposes a web resource for information and data analysis tools for the NR research community, as well as a community research grant program that will generate global-scale 'omics datasets for distribution via the web resource. These initiatives will have tangible benefits for the progress of research in the field towards developing novel NR- and coregulator-based therapeutics.

在过去的十年中，NR 信号领域已经生成了大量的全球数据集 共同描述 NR 和辅助调节基因的序列（基因组学）； NR 的监管和 特定靶组织中基因网络的共调节因子（转录组学）；蛋白质-蛋白质相互作用 NR 和 coregtjiators 有效发挥作用所需（蛋白质组学）； NRs 的特定作用位点 靶基因启动子（顺反组学）；染色质的共价修饰（表观基因组学）；而且，最近， 以细胞代谢途径（代谢组学）调节形式的特定功能终点。为了 为了有效利用这些资源，我们建议继续开发核受体 Signaling Atlas (NURSA) 网络资源将组装和集成这些数据集，构建用户友好的 数据分析工具并将其呈现给社区以进行假设生成和验证。为了充分 吸引研究界参与，我们建议管理 NURSA 数据源项目计划 （NDSP）将生成新的全球规模数据集，这些数据集将提交到网站并集成 与现有数据集。我们还将开展外展工作，为研究成员提供 社区作为附属成员参与 NURSA，并在其期间测试软件工具 发展。在社区的参与下，我们预计 NURSA 将成为一个重要的 该领域的研究资源。 相关性（参见说明）： 核受体 (NR) 和共调节因子是许多不同疾病状态的重要治疗靶点 包括癌症、肥胖、糖尿病、炎症、神经系统疾病和衰老疾病。这 应用程序为 NR 研究界提供了一个信息和数据分析工具的网络资源， 以及一个社区研究资助计划，该计划将生成全球范围的“组学数据集” 通过网络资源分发。这些举措将为研究进展带来实实在在的好处 该领域致力于开发基于 NR 和核心调节剂的新型疗法。