International Labor Migration, Armed Conflict and Dementia Risk in Nepal: A Population Study

尼泊尔的国际劳工移民、武装冲突和痴呆症风险：人口研究

• 批准号: 10535019
• 负责人: Dirgha J Ghimire
• 金额: $ 77.76万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10535019
• 关键词: Address; Adult; Affect; Age; Aging; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Chronic; Chronic Disease; Clinical; Cohort Studies; Collaborations; Conflict (Psychology); Country; Data; Data Collection; Dementia; Development; Economic Factors; Educational workshop; Elderly; Enrollment; Exposure to; Face; Family; Family Study; Foundations; Future; General Population; Health; Household; Impaired cognition; Incidence; Income; Infrastructure; Institutes; International; Interview; Investigation; Labor Migrations; Long-Term Effects; Longitudinal Studies; Longitudinal cohort study; Methods; Michigan; Modeling; Nepal; Nerve Degeneration; Outcome; Participant; Policies; Politics; Population; Population Research; Population Study; Prevalence; Prevention; Prevention strategy; Program Sustainability; Research; Research Activity; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Series; Social Environment; Statistical Data Interpretation; Statistical Methods; Surveys; Testing; Time; Training; Universities; Work; age related; aged; aging population; caregiving; cognitive testing; cohort; complex data; dementia risk; design; disability; experience; follow-up; longitudinal analysis; low and middle-income countries; low income country; novel; population based; population survey; programs; social; social factors; social relationships; virtual

The overall objective of this application is to lay the foundation for a sustainable program of population-based research into Alzheimer’s disease and related dementias (ADRD) in Nepal. To that end, the project seeks to initiate a series of research capacity building activities and develop a new, population-based, longitudinal cohort study of ADRD and related age-associated chronic health conditions in this population. Population aging is becoming increasingly more common in many low- and middle-income countries (LMIC). As a result, these countries face the growing burden of common age-associated chronic illnesses, including ADRD. Nepal is a low middle-income country where the population is now aging, putting a rising number of adults at risk of developing ADRD. There is virtually no research capacity in Nepal to investigate the scope and primary determinants of ADRD, and even the most basic information on ADRD is currently lacking. Such information is urgently needed to guide the development of prevention strategies and reduce the burden of ADRD in this country. Capacity building activities will focus on training in survey data collection methods with a primary focus on ascertainment of ADRD and statistical methods for the analysis of complex data from longitudinal panel surveys. The activities will consist of workshops with hands-on experience in the design and administration of cognitive assessments to identify ADRD in the general population, and in statistical analysis methods for longitudinal data from complex surveys. The project will also begin a new, longitudinal cohort study of ADRD designed to fill substantial gaps in information on ADRD and its primary risk factors in Nepal. It will focus on two novel risk factors with particular salience to understand the burden of ADRD in Nepal. The first involves the role of international labor migration: a substantial portion of Nepali adults spend prolonged periods of adulthood working in other countries to earn income for their families, often in challenging situations. The second risk factor involves the long-term effects of exposure to armed conflict that has affected this population for 10 years (1996-2006). The impact of labor migration and armed conflict on ADRD risk is currently unknown. The study will leverage the data collection infrastructure that has been developed for the Chitwan Valley Family Study, a population survey of >10,000 participants aged 15-59 that started in 1996. The cohort is now aging, providing a unique opportunity to begin a new population study of ADRD and other chronic health conditions. The study will include the estimated 4,000 surviving participants who have now become age-eligible (> 50) for this study. This sample will be invited for a baseline interview, including a detailed cognitive assessment, and a follow-up interview two years later. Outcomes from the capacity building and research activities will be shared with relevant stakeholders and organizations in Nepal to inform local solutions and policies for the prevention and treatment of ADRD in this population. We anticipate that much of this work will have relevance for other low-resource, low-income countries that face similar circumstances and challenges as Nepal.

该应用程序的总体目的是为基于人群的可持续计划奠定基础 尼泊尔的阿尔茨海默氏病和相关痴呆症（ADRD）的研究。为此，该项目试图 发起一系列研究能力建设活动，并开发新的，基于人群的纵向活动 该人群中ADRD和相关年龄相关的慢性健康状况的队列研究。人口衰老 在许多低收入和中等收入国家（LMIC）中越来越普遍。结果，这些 各国面临着包括年龄相关的慢性疾病的日益严重的烧伤。尼泊尔是 低收入国家现在人口正在老化，使成年人数量增加 开发adrd。尼泊尔几乎没有研究能力来研究范围和主要的范围 确定ADRD，甚至目前缺乏有关ADRD的最基本信息。这样的信息是 迫切需要指导预防策略的制定并减少ADRD的燃烧 国家。能力建设活动将重点放在调查数据收集方法中的培训，主要重点 关于确定ADRD和统计方法，用于分析纵向图的复杂数据 调查。活动将包括在设计和管理方面具有动手经验的研讨会 认知评估以识别普通人群中的ADRD，并在统计分析方法中 复杂调查的纵向数据。该项目还将开始对ADRD进行的新的纵向队列研究 旨在填补有关ADRD及其主要风险因素的大量信息。它将重点 有两个新颖的风险因素，特别明显，以了解尼泊尔的ADRD燃烧。第一个涉及 国际劳工移民的作用：大部分尼泊尔成年人花费了很长时间 在其他国家工作，通常在挑战情况下为家人赚取收入。这 第二个风险因素涉及影响该人群的武装冲突的长期影响 10年（1996- 2006年）。目前尚不清楚劳动移民和武装冲突对ADRD风险的影响。 该研究将利用为Chitwan Valley家族开发的数据收集基础设施 研究，对​​1996年开始的15-59岁参与者> 10,000名参与者的人口调查。该队列现在已经老化， 提供了一个独特的机会，开始对ADRD和其他慢性健康状况进行新的人口研究。 该研究将包括估计已成为年龄符合年龄的4,000名生存参与者（> 50） 这项研究。该样本将被邀请进行基线访谈，包括详细的认知评估和 后续采访两年后。能力建设和研究活动的结果将分享 与尼泊尔的相关利益相关者和组织一起，向当地解决方案和政策提供了预防的政策 和在该人群中对ADRD的治疗。我们预计这项工作的大部分将与其他工作有关 低资源，低收入国家面临与尼泊尔相似的环境和挑战。