Mental Health in Autistic Adults: And RDoC Approach

成人自闭症患者的心理健康：和 RDoC 方法

基本信息

批准号：
10523167
负责人：
Carla A Mazefsky
金额：
$ 21.66万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-06 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10523167
关键词：
Advocacy Age Ally Brain Calibration Categories Clinical Comprehension Data Development Diagnosis Dimensions Ensure Equipment and supply inventories Factor Analysis Feeling suicidal General Population Generations Goals Growth Hour Individual Information Systems Life Measurement Measures Mental Health Modeling Negative Valence Participant Patient Outcomes Assessments Patient Self-Report Positive Valence Probability Process Psychometrics Quality of life Questionnaires Reporting Research Research Domain Criteria Risk Risk Factors Safety Sampling Sensory Social Processes Subgroup Suicide Suicide attempt Symptoms System Testing Time Training United States National Institutes of Health Work adult with autism spectrum disorder autism spectrum disorder autistic base burnout cognitive interview cognitive system demographics design human old age (65+)improved indexing individuals with autism spectrum disorder machine learning model prospective psychosocial random forest response screening sex sound suicidal behavior suicidal risk suicide model suicide rate theories therapy development trait

项目摘要

ABSTRACT- Project 1 Suicide rates in autistic adults are alarming high in recent research; 4- 72% have endorsed suicidal ideation and 4-33% have engaged in suicidal behavior or attempts. Both scientific and advocacy groups have endorsed research for effective suicidality assessment and identification of risk factors. However, existing suicidality screening measures do not seem to function in the same way for autistic adults, and to date, no research has used a measure of suicide risk rather than a screen of imminent risk. Adaptation of existing suicide screens may be insufficient, given evidence that autistic adults may have unique risk factors, such as camouflaging of autistic traits and autistic burnout. This study will develop a suicidality measure for autistic adults, the Autism Suicidality Inventory, that will capture a continuum of suicide risk. Autistic adults and their allies will refine an item pool, and 25 autistic adults (at least 10 of which with suicidality) will complete cognitive interviews of the drafted items to ensure clarity and comprehension. A sample of 1000 autistic and non-autistic adults will complete the drafted questionnaire and a related online battery of measures to evaluate the dimensionality of the item pool, conduct Item Response Theory calibration, and compare existing suicide measures to the proposed questionnaire via IRT co-calibration. A subsample of 300 autistic and non-autistic participants (the ACE core sample) will repeat the measure every two months for a year, and cross-project analyses will examine whether those who report more suicidality baseline also report more suicidal ideation in daily life, model suicide risk over time via latent growth models, and identify factors that are most strongly associated with suicidality trajectories. The Autism Suicidality Inventory will be the first validated suicide propensity measure developed for ASD, designed with input from autistic adults and capturing a continuum of risk via an emphasis on processes that relate to risk. The availability of such a measure is essential to inform intervention development to improve safety and quality of life.

摘要 - 项目1 自闭症成年人的自杀率在最近的研究中令人震惊。 4-72％认可自杀念头和4-33％的人从事自杀行为或尝试。科学和倡导团体都认可有效自杀评估和识别危险因素的研究。但是，现有的自杀性对于自闭症成年人而言，筛查措施似乎并没有以相同的方式运作，迄今为止，没有研究使用了自杀风险的量度，而不是迫在眉睫的风险屏幕。现有自杀屏幕的改编鉴于有证据表明自闭症成年人可能具有独特的危险因素，例如伪装自闭症特征和自闭症倦怠。这项研究将针对自闭症的自闭症成年人制定自杀措施自杀性清单将捕获自杀风险的连续性。自闭症成年人及其盟友将完善物品池和25名自闭症成年人（至少有10名自杀性）将完成有关的认知访谈起草项目以确保清晰度和理解。 1000个自闭症和非自动主义成年人的样本将填写草稿问卷和相关的在线措施，以评估项目池，进行项目响应理论校准，并将现有的自杀措施与通过IRT共校准提出的问卷。 300名自闭症和非自动参与者的子样本（ ACE核心样本）将每两个月重复一年的措施，然后进行跨项目分析检查那些报告更多自杀性基线的人是否还报告了日常生活中更多的自杀意念，通过潜在增长模型随着时间的推移自杀风险，并确定最密切相关的因素具有自杀轨迹。自闭症自杀量清单将是第一个经过验证的自杀倾向为ASD开发的措施，由自闭症成年人的输入设计，并通过强调与风险有关的过程。这种措施的可用性对于告知干预至关重要发展以提高安全和生活质量。