Heterogeneous Effects of Education on Alzheimers Disease and Related Dementia among Demographic Groups: A Multigenerational and Multilevel Study

教育对人口群体中阿尔茨海默病和相关痴呆症的异质性影响：一项多代、多层次的研究

• 批准号: 10512877
• 负责人: Liying Luo
• 金额: $ 36.23万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10512877
• 关键词: Address; Adult; Affect; Alzheimer' s disease related dementia; Baby Booms; Biosocial; Birth; Black Populations; Characteristics; Child; Cohort Analysis; County; Data; Data Set; Data Sources; Disadvantaged; Education; Ethnic group; Exposure to; Family; Family member; Future; Generations; Goals; Health and Retirement Study; Hispanic Populations; Impaired cognition; Individual; Inequality; Longitudinal Studies; Measures; Mediating; Mediation; Mediator of activation protein; Methodology; Not Hispanic or Latino; Parents; Pathway interactions; Pattern; Population; Population Process; Public Health; Research; Research Design; Research Personnel; Resources; Respondent; Risk Factors; Role; Schools; Social Environment; Time; cohort; college; contextual factors; dementia risk; disparity reduction; ethnic difference; ethnic minority population; health data; improved; innovation; insight; intergenerational; novel; novel strategies; population health; protective effect; racial and ethnic; racial and ethnic disparities; racism; sociodemographic disparity; sociodemographic factors; socioeconomics; supportive environment; tool

PROJECT SUMMARY The protective effect of education against Alzheimer’s disease and related dementias (ADRD) is found to be smaller for racial/ethnic minority individuals than for non-Hispanic White individuals. Identifying factors that modify or mediate the education-ADRD relationship presents a unique opportunity to address the racial/ethnic disparities in ADRD and ultimately improve population health. However, most research relies on respondents’ education to assess the education-ADRD relationship, failing to consider the roles of other family member’s education or the social context and environment in which education occurs and affects ADRD. The major goal of the proposed research is to develop a novel framework that incorporates multigenerational education and multidomain contextual measures and use it to clarify the heterogeneous effects of education on ADRD risk among racial/ethnic groups by analyzing nationally representative longitudinal data. We propose to achieve this goal through three specific aims. In Aim 1, we will develop a multigenerational framework and use it to estimate the effect of multigenerational education on the respondent’s ADRD risk and the racial/ethnic disparities. Aim 2 is to construct multidomain contextual measures of structural inequality and racism and estimate their effects on individual’s ADRD risk and the racial/ethnic disparities. To provide historical and population contexts for understanding results from Aims 1 and 2, in Aim 3 we will estimate how education effects on ADRD risk may differ across four birth cohorts. The proposed research is significant because it will help reduce racial/ethnic disparities in cognitive impairment and ADRD risk by clarifying multigenerational pathways and identifying mediators and modifiers of the heterogeneous education-ADRD relationships among demographic groups. The proposed research is innovative because it will develop a new multigenerational and multilevel mediation approach to understanding why the education-ADRD risk relationship differs among racial/ethnic groups. It will also contribute new contextual data to a nationally representative data set.

项目摘要 发现对阿尔茨海默氏病和相关痴呆症（ADRD）的教育影响是 对于种族/族裔少数民族个人而言，比非西班牙裔白人小。确定因素 修改或调解教育 - 阿德德关系为解决种族/族裔提供了独特的机会 ADRD的差异并最终改善了人口健康。但是，大多数研究都依赖受访者的 评估教育关系的教育，未能考虑其他家庭成员的角色 教育或教育发生并影响ADRD的社会环境和环境。主要目标 拟议的研究是开发一个新颖的框架，该框架结合了多代教育和 多域的情境措施并使用它来阐明教育对ADRD风险的异质影响 在种族/族裔群体中，通过代表纵向数据的全国分析。我们建议实现这一目标 通过三个特定目标实现目标。在AIM 1中，我们将开发一个多代框架并使用它来估算 多代教育对受访者的ADRD风险和种族/种族差异的影响。目标2 是构建结构性不平等和种族主义的多域情境衡量，并估算其对 个人的ADRD风险和种族/种族差异。为历史和人口环境提供 了解目标1和2的结果，在AIM 3中，我们将估计教育对ADRD风险的影响可能如何 在四个出生队列中不同。 拟议的研究很重要，因为它将有助于减少认知障碍的种族/种族差异 和ADRD风险通过确定多代途径并确定调解人和修饰符 人口群体之间的异构教育关系。拟议的研究是 创新性，因为它将开发出一种新的多代和多层次调解方法来理解 为什么教育的风险关系在种族/族裔群体之间有所不同。它也会做出新的贡献 上下文数据到全国代表性数据集。