Northwestern University Clinical and Translational Science Institute (NUCATS)

西北大学临床与转化科学研究所 (NUCATS)

• 批准号: 10650847
• 负责人: Susanna A McColley
• 金额: $ 53.07万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-12 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10650847
• 关键词: Address; Adolescent; Adult; Basic Science; Brain Neoplasms; Child Health; Childhood; Clinical; Clinical Sciences; Collaborations; Communication; Communities; Complement; Computers; Creativeness; Data Engineering; Data Science; Data Scientist; Discharge Plannings; Discipline; Disparate; Doctor of Philosophy; Economics; Educational Curriculum; Elements; Engineering; Environment; Funding; General Anesthesia; Goals; Health; Individual; Institution; Leadership; Learning; Life Cycle Stages; Machine Learning; Mentors; Minority-Serving Institution; Modernization; Nanotechnology; Patient Care; Pediatric Research; Pediatrics; Positioning Attribute; Postbaccalaureate; Postdoctoral Fellow; Research; Research Personnel; Students; TNFSF15 gene; Talents; Technology; Training; Training Activity; Training Programs; Translating; Translational Research; Underrepresented Minority; Universities; Work; Writing; adolescent health; bridge program; career; doctoral student; experience; improved; innovation; interest; multidisciplinary; novel; novel strategies; pediatrician; peer; post-doctoral training; pre-doctoral; programs; summer research; tool; translational health science

ABSTRACT: The health of children and adolescents is a critical determinant of our nation's health over the entire life course. Yet, research into child health lags behind that for adults. In part, this reflects historical, cultural and economic forces that tend to divert investigators into careers other than pediatric research. To address this concern, the Northwestern University Clinical and Translational Sciences Institute (NUCATS) chose the unique approach of specifically training young investigators to apply engineering solutions to problems in child health. Our overall goal is to generate a community of pediatricians, data scientists and engineers who collaborate across disciplines, using modern technology to improve the health of children and adolescents. The central focus of this continuing and highly successful effort is this Multidisciplinary Training Program in Child and Adolescent Health TL1, which has three specific aims. In Aim 1, we will train 10 postdoctoral fellows in basic science or pediatrics for two years, in a creative and multidisciplinary environment where investigators are equipped to apply innovative engineering approaches to problems in child and adolescent health. The fellows must have a mentor in both pediatrics and engineering. Presently, their projects range from computer-controlled delivery of general anesthesia or using nanotechnology to treat brain tumors, to applying machine learning to optimize discharge planning. This innovative research experience is complemented by mentoring from the TL1 leadership and from their postdoctoral-fellow peers; required foundational elements, which promote communication across traditionally disparate scientific disciplines; required selective components, assigned to individual fellows to optimize their training in pediatric clinical and translational science; and a menu of enrichment opportunities that are optional for each trainee. All of these components include both didactic and experiential approaches. In Aim 2, to expand the pipeline of engineers entering child and adolescent health research, we will provide 2, one-year positions (1 supported by the CTSA and 1 by institutional funds) for predoctoral engineers entering the last year of PhD training, especially those representing underrepresented minorities, as they complete their research and write their thesis. By including engineering trainees who are interested in CTS in the training activities available to our TL1 postdoctoral fellows, we intend to enhance their potential commitment to pediatric translational science. Finally, in Aim 3, we will provide a summer research experience at Northwestern for 4 students in clinical post-baccalaureate programs at a traditionally underrepresented-minority institution. Our experience to date suggests that, with our ongoing involvement after the summer experience, many of these students have been inspired to seek careers in translational research. Together, these aims outline a comprehensive and successful program to increase the number and quality of investigators applying innovative approaches to improving child and adolescent health.

摘要：儿童青少年的健康是国民健康的重要决定因素。 生命历程。然而，对儿童健康的研究落后于成人。这在一定程度上反映了历史、文化和 经济力量往往会将研究人员转移到儿科研究以外的职业上。为了解决这个问题 值得关注的是，西北大学临床与转化科学研究所 (NUCATS) 选择了独特的 专门培训年轻研究人员将工程解决方案应用于儿童健康问题的方法。 我们的总体目标是建立一个由儿科医生、数据科学家和工程师组成的协作社区 跨学科，利用现代技术改善儿童和青少年的健康。中央 这项持续且非常成功的努力的重点是儿童和儿童多学科培训计划 青少年健康 TL1，具有三个具体目标。目标一：培养10名基础博士后 科学或儿科为期两年，研究人员在创造性和多学科的环境中 具备应用创新工程方法解决儿童和青少年健康问题的能力。同胞们 必须有儿科和工程学方面的导师。目前，他们的项目范围包括计算机控制 全身麻醉或使用纳米技术治疗脑肿瘤，应用机器学习 优化排放计划。这种创新的研究经验得到了 TL1 的指导的补充 领导力和博士后同行的帮助；所需的基本要素，促进 传统上不同的科学学科之间的交流；所需的选择性组件，分配给 个别研究员优化他们在儿科临床和转化科学方面的培训；和一个菜单 每个学员可选择的丰富机会。所有这些组成部分都包括教学和 经验方法。目标 2：扩大进入儿童和青少年健康领域的工程师队伍 研究，我们将提供 2 个为期一年的职位（1 个由 CTSA 支持，1 个由机构基金支持） 进入博士培训最后一年的博士前工程师，特别是那些代表性不足的工程师 少数族裔，因为他们完成了研究并撰写了论文。通过包括以下工程实习生 我们对 TL1 博士后研究员提供的培训活动中的 CTS 感兴趣，我们打算提高他们的能力 对儿科转化科学的潜在承诺。最后，在目标 3 中，我们将提供夏季研究 西北大学 4 名学生在传统的临床学士后课程中的经验 代表性不足的少数族裔机构。我们迄今为止的经验表明，随着我们在 通过暑期经历，许多学生受到启发，开始寻求转化研究的职业。 这些目标共同概述了一个全面且成功的计划，以提高 研究人员应用创新方法来改善儿童和青少年的健康。

项目成果

Spinal dura mater: biophysical characteristics relevant to medical device development.

• DOI: 10.1080/03091902.2018.1435745
• 发表时间: 2018-03
• 期刊: Journal of medical engineering & technology
• 作者: Nagel SJ;Reddy CG;Frizon LA;Chardon MK;Holland M;Machado AG;Gillies GT;Howard MA 3rd;Wilson S
• 通讯作者: Wilson S

Provider education leads to sustained reduction in pediatric opioid prescribing after surgery.

• DOI: 10.1016/j.jpedsurg.2021.08.004
• 发表时间: 2022-03
• 期刊: Journal of pediatric surgery
• 影响因子: 2.4
• 作者: Slater BJ;Corvin CG;Heiss K;Vandewalle R;Shah SR;Cunningham M;Huang E;Lipskar AM;Denning NL;Dassinger M;Cina RA;Rothstein DH;Kauffman J;Gonzalez R;Ingram MC;Raval MV
• 通讯作者: Raval MV

Enhancing clinical trial development for pediatric kidney diseases.

加强儿科肾脏疾病的临床试验开发。

• DOI: 10.1038/pr.2017.180
• 发表时间: 2017
• 期刊: Pediatric research
• 影响因子: 3.6
• 作者: Schnaper,HWilliam;Flynn,JosephT;Gross,Coleman;Cropp,AnneB;Dehmel,Bastian;Patel,LeahB;Greenbaum,LarryA;Houtsmuller,Elisabeth;Kaskel,Frederick;Moxey-Mims,Marva;Nowak,Karen;Silverstein,Douglas;Thompson,Aliza;Yao,Lynne;Darsey,
• 通讯作者: Darsey,

Development of Optimized Tissue-Factor-Targeted Peptide Amphiphile Nanofibers to Slow Noncompressible Torso Hemorrhage.

• DOI: 10.1021/acsnano.9b09243
• 发表时间: 2020-06-23
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Klein MK;Kassam HA;Lee RH;Bergmeier W;Peters EB;Gillis DC;Dandurand BR;Rouan JR;Karver MR;Struble MD;Clemons TD;Palmer LC;Gavitt B;Pritts TA;Tsihlis ND;Stupp SI;Kibbe MR
• 通讯作者: Kibbe MR

RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy.

• DOI: 10.1016/j.stem.2021.08.006
• 发表时间: 2021-12-02
• 期刊: Cell stem cell
• 影响因子: 23.9
• 作者: Magdy T;Jiang Z;Jouni M;Fonoudi H;Lyra-Leite D;Jung G;Romero-Tejeda M;Kuo HH;Fetterman KA;Gharib M;Burmeister BT;Zhao M;Sapkota Y;Ross CJ;Carleton BC;Bernstein D;Burridge PW
• 通讯作者: Burridge PW