Coordinating center for collaborative marmoset research

狨猴协作研究协调中心

• 批准号: 10651680
• 负责人: DONALD F. CONRAD
• 金额: $ 62万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10651680
• 关键词: Acute; Adoption; Agreement; American; Animal Model; Animals; BRAIN initiative; Behavior; Biology; Breeding; Callithrix; Callithrix jacchus jacchus; Censuses; Cognition; Collaborations; Communication; Communities; Country; Data; Data Aggregation; Data Management Resources; Discipline; Equipment and supply inventories; Evaluation; Event; Foundations; Funding; Gene Targeting; Genetic; Genotype; Genotype-Tissue Expression Project; Human Resources; Individual; Informatics; Infrastructure; Intake; Internet; Laboratories; Letters; Manuals; Mental disorders; Methodology; Modeling; Neurosciences; Neurosciences Research; Oregon; Population; Practice Guidelines; Primates; Production; Protocols documentation; Research; Research Personnel; Resources; Scientist; Services; Structure; System; Time; United States; United States National Institutes of Health; Update; Wisconsin; data resource; design; experience; genetic information; genetic manipulation; genetic pedigree; genome editing; interest; nonhuman primate; programs; research study; statistics; web portal; web site

PROJECT SUMMARY/ABSTRACT The common marmoset (Callithrix jacchus) has emerged as a critically important and tractable non-human primate (NHP) model for neuroscience research accommodating genetic manipulation and directed breeding. Several barriers to the adoption of marmoset models by the neuroscience community exist, including a small census size in the United States (fewer than 2,500 animals), poor communication about resource availability, a poor understanding of the strengths and limitations of marmosets in research, and a lack of a formal structure for coordinating the sharing of information and resources related to marmoset research. In this application, we propose to establish a Marmoset Coordinating Center (MCC) as part of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative that will address these limitations by building upon our experience in NHP informatics and marmoset research. As the foundation for the MCC, we will build a new informatics framework for coordinating marmoset research based on the LabKey data management system. This infrastructure will be derived from the existing LabKey system in place at multiple National Primate Research Centers, and which has been optimized for NHP research, including marmosets, over years of production. This informatics system will be initialized with basic statistics on the marmoset laboratory populations provided by participating centers, making pre-recorded, individual-level information that is already recorded more broadly available to the neuroscience community. Demographic and genetic information will be shared and discussed among participating centers, to coordinate marmoset colony management in line with American Zoological Association practice guidelines. Once operational, the MCC will be comprised of two parts: 1) a web-based portal to provide access to the marmoset data resources stored in LabKey, as well as background content on marmoset biology and neuroscience; 2) a concierge comprised of MCC staff and augmented by a scientific advisory board of marmoset neuroscience experts. The website will provide summaries of existing marmoset neuroscience projects, and allow interested investigators to search animal inventory and request animals. The concierge will be available to answer basic questions about the Center and the use of marmosets in neuroscience. Together, the data and human resources of the MCC will provide an essential portal into marmoset neuroscience research through collaboration, service agreement, or animal transfer.

项目摘要/摘要 普通的marmoset（callithrix jacchus）已成为至关重要且可拖延的非人类 灵长类动物（NHP）神经科学研究模型，可容纳遗传操纵和定向育种。 神经科学界采用摩尔莫斯特模型的几个障碍，包括一个小的 美国的人口普查大小（少于2500只动物），关于资源可用性的沟通不良， 对研究在研究中的优势和局限性的理解不足，缺乏正式结构 用于协调与Marmoset Research相关的信息和资源共享。 在此应用程序中，我们建议建立一个Marmoset协调中心（MCC）作为NIH大脑的一部分 通过推进创新神经技术（BRAIT）计划的研究，该计划将解决这些限制 通过我们在NHP信息学和Marmoset研究方面的经验来建立。作为MCC的基础，我们 将建立一个新的信息学框架，以根据Labkey数据协调Marmoset研究 管理系统。该基础架构将从现有的Labkey系统派生到适当的位置 国家灵长类动物研究中心，并已针对NHP研究进行了优化，包括Marmosets， 多年的生产。此信息系统将通过Marmoset的基本统计数据初始化 参与中心提供的实验室人口，提供预先录制的个人级信息 已经记录到神经科学社区更广泛地使用。人口统计学和遗传 信息将在参与中心之间共享和讨论，以协调Marmoset Colony 根据美国动物协会实践指南的管理。 一旦运行，MCC将由两个部分组成：1）基于Web的门户，可提供对 Labkey中存储的Marmoset数据资源以及Marmoset生物学和背景内容 神经科学； 2）由MCC工作人员组成的礼宾，并由Marmoset的科学顾问委员会增强 神经科学专家。该网站将提供现有Marmoset神经科学项目的摘要，并提供 允许感兴趣的研究人员搜索动物清单并要求动物。礼宾将可用 回答有关该中心和在神经科学中使用摩尔果的基本问题。在一起，数据和 MCC的人力资源将通过 协作，服务协议或动物转移。