CAROLINA CANCER NANOTECHNOLOGY TRAINING PROGRAM (C-CNTP)

卡罗莱纳州癌症纳米技术培训计划 (C-CNTP)

• 批准号: 10650745
• 负责人: ALEXANDER V KABANOV
• 金额: $ 38.86万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650745
• 关键词: Malignant Neoplasms; Nanotechnology; Training Programs

This proposal seeks competing continuation of the NIH T32 Carolina Cancer Nanotechnology Training Program (C-CNTP). The program started in 2015 with the support of the NIH Ruth L. Kirschstein National Research Service Award. The goal of the program is to make a major contribution to the growth of the cancer nanotechnology workforce by providing training and research experience to a highly select cohort of postdoctoral fellows. During four years since its initiation the program has recruited 15 excellent fellows of whom 5 have completed training and moved into tenure track assistant professors, industry and FDA positions, 8 continue training with the NIH T32 support and 2 are in the final stages of training with other support sources in the labs of their mentors. We have assembled a team of 20 outstanding Program faculty from 11 departments and 3 schools at the University of North Carolina Chapel Hill with specific expertise in physical and material sciences, chemistry, pharmacoengineering, drug delivery, computational modeling as well as basic biomedical research and clinical science, all of whom have demonstrated strong interests, capabilities and collaborations at the interface between nanoscience and cancer. The objectives of the C-CNTP are to: 1) recruit an elite group of talented postdoctoral fellows from diverse backgrounds with PhD, MD or PharmD and provide them with outstanding postdoctoral experience including focused didactic training and co-mentored research experience with faculty mentors from complementary fields; 2) provide each trainee with intensive introductory training with online video library of recorded lectures followed by workshops and didactic courses to remediate differences in their backgrounds and to deepen the knowledge and understanding in the key areas of cancer nanotechnology; and 3) facilitate transition of trainees to independence by providing them with opportunities to a) conduct original cancer nanotechnology research projects; b) apply for the individual cancer nanotechnology Pilot Grants within C-CNTP, and c) acquire written and oral communications skills needed to publish manuscripts, report results, and write successful individual extramural support applications focused on problems of cancer nanotechnology. We are committed to developing a world-class postdoctoral training program that capitalizes on the existing strengths in cancer nanotechnology research, consolidates diverse research and education resources across several academic units, and becomes a significant contributor to addressing the Nation's research needs in cancer nanotechnology.

该建议寻求NIH T32卡罗来纳州癌症纳米技术培训计划的竞争继续 （C-CNTP）。该计划始于2015年，在NIH Ruth L. Kirschstein国家研究的支持下 服务奖。该计划的目的是为癌症的成长做出重大贡献 纳米技术员工队伍通过为高度精选的博士后提供培训和研究经验 研究员。自启动以来的四年中，该计划招募了15名优秀研究员，其中5名 完成了培训，并搬到了终身轨道助理教授，行业和FDA职位，8继续 NIH T32支持和2的培训处于实验室中其他支持资源的培训的最后阶段 他们的导师。我们组建了一个来自11个部门和3个部门的20名杰出计划教师的团队 北卡罗来纳大学教堂山的学校具有特定的物理和物质科学专业知识， 化学，药剂工程，药物输送，计算建模以及基本生物医学研究 和临床科学，所有人都表现出强烈的利益，能力和合作 纳米科学与癌症之间的接口。 C-CNTP的目标是：1）招募一组精英组 来自不同背景的才华横溢的博士学位，医学博士或PharmD的人才为他们提供 杰出的博士后经验，包括专注的教学培训和联合研究经验 来自互补领域的教师导师； 2）为每个学员提供深入的入门培训 在线录制讲座的视频库，然后是研讨会和教学课程，以补救差异 它们的背景并加深了癌症纳米技术关键领域的知识和理解； 3）通过为学员提供机会来促进学员过渡到独立性 癌症纳米技术研究项目； b）在内部申请单个癌症纳米技术飞行员赠款 C-CNTP以及C）获得发表手稿所需的书面和口头通信技能，报告结果， 并编写针对癌症纳米技术问题的成功的个人外部支持应用。 我们致力于制定一项世界一流的博士后培训计划，该计划利用现有的 癌症纳米技术研究的优势，巩固了各种研究和教育资源 几个学术单位，并成为满足国家研究需求的重要贡献 癌症纳米技术。

项目成果

Preparation of an Orthotopic, Syngeneic Model of Lung Adenocarcinoma and the Testing of the Antitumor Efficacy of Poly(2-oxazoline) Formulation of Chemo-and Immunotherapeutic Agents.

肺腺癌原位同基因模型的制备以及化疗和免疫治疗剂聚（2-恶唑啉）制剂的抗肿瘤功效测试。

• DOI: 10.21769/bioprotoc.3953
• 发表时间: 2021
• 期刊: Bio-protocol
• 影响因子: 0.8
• 作者: Vinod,Natasha;Hwang,Duhyeong;Azam,SalmaH;VanSwearingen,AmandaED;Wayne,Elizabeth;Fussell,SloaneChristian;Sokolsky-Papkov,Marina;Pecot,ChadV;Kabanov,AlexanderV
• 通讯作者: Kabanov,AlexanderV

Targeting Accessories to the Crime: Nanoparticle Nucleic Acid Delivery to the Tumor Microenvironment.

• DOI: 10.3389/fphar.2018.00307
• 发表时间: 2018
• 期刊: Frontiers in pharmacology
• 影响因子: 5.6
• 作者: Harrison EB;Azam SH;Pecot CV
• 通讯作者: Pecot CV

Influenza Virus and SARS-CoV-2 Vaccines.

• DOI: 10.4049/jimmunol.2001287
• 发表时间: 2021-06-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Sandor AM;Sturdivant MS;Ting JPY
• 通讯作者: Ting JPY

Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma.

纤维蛋白凝胶增强胶质母细胞瘤中嵌合抗原受体 T 细胞的抗肿瘤作用。

• DOI: 10.1126/sciadv.abg5841
• 发表时间: 2021-10-08
• 期刊: Science advances
• 影响因子: 13.6
• 作者: Ogunnaike EA;Valdivia A;Yazdimamaghani M;Leon E;Nandi S;Hudson H;Du H;Khagi S;Gu Z;Savoldo B;Ligler FS;Hingtgen S;Dotti G
• 通讯作者: Dotti G

Complex effects of tumor microenvironment on the tumor disposition of carrier-mediated agents.

• DOI: 10.2217/nnm-2017-0101
• 发表时间: 2017-07
• 期刊: Nanomedicine
• 影响因子: 5.5
• 作者: A. Lucas;Lauren S. L. Price;Allison N. Schorzman;W. Zamboni