Administration and statistical/bioinformatics core

管理和统计/生物信息学核心

• 批准号: 10647769
• 负责人: Judith Campisi
• 金额: $ 28.17万
• 依托单位: BUCK INSTITUTE FOR RESEARCH ON AGING
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10647769
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Applications Grants; Bioinformatics; Brain; Budgets; Cell Aging; Cells; Collaborations; Communication; Communities; Computer software; Consultations; Data; Data Analyses; Databases; Dedications; Dementia; Emotional; Ensure; Equipment; Evaluation; Faculty; Financial Hardship; Fostering; Funding; Goals; Grant; Human Resources; Individual; Institution; Joints; Manuscripts; National Institute on Aging; Participant; Postdoctoral Fellow; Principal Investigator; Program Research Project Grants; Progress Reports; Proteomics; Published Comment; Reproducibility; Research Personnel; Resolution; Science; Services; Students; Training; Travel; United States; United States National Institutes of Health; Visit; age related; aged; career development; data management; design; experimental study; large datasets; meetings; member; metabolomics; multiple omics; program dissemination; success; symposium; transcriptome sequencing; web site

PROJECT SUMMARY This program project grant (PPG) proposes to explore important, fundamental aspects of aging that can result in the loss of brain function that occurs during aging. This loss of brain function, often termed Alzheimer's disease (AD) and related dementias (ADRD), imposes enormous emotional and financial burdens on citizens of the United States, and worldwide. Core A will organize and coordinate the entire PPG, and will be crucial for the success of its scientific goals. The Core will be led by the PPG Principal Investigators Judith Campisi and Lisa Ellerby. It will provide essential functions to the PPG, which will be implemented through seven interlinked specific aims. These aims include facilitating communication and collaboration among the Projects (Projects 1-3) and other Cores (Cores B-D), organizing regular meetings among the Project and Core personnel and members of the Scientific Advisory Board (SAB), which will provide critical assessments of the scientific and administrative progress of the PPG. Core A will also provide budgetary and administrative support and oversight, be responsible for communicating with the National Institute on Aging (NIA), including submission of progress reports and discussions of any new or altered scientific directions. In addition, Core A will facilitate and organize training and travel for SAB members and, importantly, for junior participants in the PPG (students, postdoctoral fellows, critical support personnel). Finally, Core A will provide unified high-level statistical and bioinformatic support to the entire PPG through dedicated hardware, software and personnel overseen by Buck faculty member David Furman. Through these aims and services, Core A will provide critical central administrative and scientific support to the PPG, which will optimize the success of its scientific aims.

项目概要 该计划项目拨款 (PPG) 提议探索老龄化的重要、基本方面，这些方面可以 导致衰老过程中发生的大脑功能丧失。这种大脑功能的丧失通常被称为 阿尔茨海默病 (AD) 和相关痴呆症 (ADRD) 带来巨大的情感和经济负担 对美国和世界各地的公民。核心A将组织和协调整个PPG，并将 对于其科学目标的成功至关重要。该核心将由 PPG 首席研究员 Judith 领导 坎皮西和丽莎·埃勒比。它将为 PPG 提供基本功能，这些功能将通过 七个相互关联的具体目标。这些目标包括促进各方之间的沟通与合作 项目（项目 1-3）和其他核心（核心 B-D），组织项目和核心之间的定期会议 科学顾问委员会（SAB）的人员和成员，他们将对 PPG 的科学和管理进展。核心 A 还将提供预算和行政管理 支持和监督，负责与国家老龄化研究所（NIA）沟通，包括 提交进度报告并讨论任何新的或改变的科学方向。此外，核心A 将促进和组织 SAB 成员的培训和旅行，更重要的是，为初级参与者提供便利 PPG（学生、博士后研究员、关键支持人员）。最后，Core A将提供统一的高层 通过专用硬件、软件和人员为整个 PPG 提供统计和生物信息支持 由巴克大学教员大卫·弗曼（David Furman）监督。通过这些目标和服务，Core A 将提供 对 PPG 的关键中央行政和科学支持，这将优化其科学的成功 目标。