Lifestyle Factors and Lymphoma: An Asia Cohort Consortium Pooling Project

生活方式因素与淋巴瘤：亚洲队列联盟联合项目

• 批准号: 8637023
• 负责人: BRIAN C-H CHIU
• 金额: $ 8.56万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-15 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8637023
• 关键词: Achievement; Address; Adult; Alcohol consumption; Alcohols; Asia; Asians; Body mass index; Cancer Etiology; Caucasians; Caucasoid Race; Cessation of life; Chronic Disease; Cohort Analysis; Cohort Studies; Country; Data; Data Analyses; Diabetes Mellitus; Ensure; Epidemiology; Ethnic group; General Population; Goals; Health; Hematologic Neoplasms; Heterogeneity; Immigrant; Immunologics; Immunosuppression; Incidence; Knowledge; Life Style; Light; Lymphoma; Meta-Analysis; Methods; Modeling; Modification; Newly Diagnosed; Non-Hodgkin' s Lymphoma; North America; Obesity; Participant; Persons; Play; Population; Prevalence; Prevention; Prevention strategy; Public Health; Publishing; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Estimate; Risk Factors; Role; Sample Size; Singapore; Smoking; Staging; Time; Tobacco smoking; Translating; United States; Western Europe; Woman; alcohol risk; cigarette smoking; cohort; cost effective; ethnic minority population; hazard; improved; innovation; lifestyle factors; malignant small intestine tumor; men; mortality; novel; population based; programs; prospective; public health relevance

DESCRIPTION (provided by applicant): Non-Hodgkin lymphoma (NHL) is the most common hematopoietic cancer among adults in the United States. Studies conducted in Caucasian populations suggested that a higher body mass and smoking may increase risk while alcohol use may lower the risk. However, it is not known whether the same relationships exist in Asian populations for which incidence rates historically have been lower than Caucasians. Given the rising prevalence of obesity and cigarette smoking in many countries in Asia and immigrants in the US, there exists an urgent need to clarify the potential role of these modifiable factors in th NHL risk. The aims of this research are to investigate the associations between deaths from lymphoma and body mass, smoking, and alcohol use in Asian populations. To accomplish these aims, we will conduct a cohort analysis using data from the Asia Cohort Consortium; consisting of 17 cohorts with over 870,000 participants and 686 recorded NHL deaths. Data on body mass, tobacco smoking, and alcohol use have already been harmonized. Data on NHL deaths and person time for the current proposal have also been obtained from each cohort. We will examine the association between deaths from NHL and body mass, smoking, and alcohol consumption using Cox proportional hazard regression models. A two- stage method for analysis of pooled data will be used to compare the risk estimates from fixed- effects models with those from random-effects models to assess the effect of heterogeneity. Using existing data from the Asia Cohort Consortium, the proposed study is extremely cost-effective for clarifying the relationship between body mass, smoking, and alcohol use and risk of NHL and extending findings to the Asian populations, one of the fastest growing ethnic groups in the United States.

描述（由申请人提供）：非霍奇金淋巴瘤（NHL）是美国成年人中最常见的造血系统癌症。在白种人人群中进行的研究表明，较高的体重和吸烟可能会增加风险，而饮酒可能会降低风险。然而，尚不清楚亚洲人群中是否存在同样的关系，因为历史上亚洲人群的发病率低于白人。鉴于亚洲许多国家和美国移民的肥胖和吸烟患病率不断上升，迫切需要阐明这些可改变因素在 NHL 风险中的潜在作用。本研究的目的是调查亚洲人群淋巴瘤死亡与体重、吸烟和饮酒之间的关联。为了实现这些目标，我们将使用亚洲队列联盟的数据进行队列分析；该研究由 17 个队列组成，共有超过 870,000 名参与者，记录了 686 名 NHL 死亡病例。关于体重、吸烟和饮酒的数据已经统一。目前提案的 NHL 死亡和人员时间数据也从每个队列中获得。我们将使用 Cox 比例风险回归模型研究 NHL 死亡与体重、吸烟和饮酒之间的关联。将使用分析汇总数据的两阶段方法将固定效应模型的风险估计与随机效应模型的风险估计进行比较，以评估异质性的影响。利用亚洲队列联盟的现有数据，拟议的研究对于阐明体重、吸烟和饮酒与 NHL 风险之间的关系以及将研究结果扩展到亚洲人群（亚洲人口增长最快的种族群体之一）而言极具成本效益。美国。